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Cliona M. Rooney

Cliona M. Rooney

Professor | Houston, Texas    United States of America
Pediatrics, Hematology-Oncology,...More
Spoken at 2 events

Biography :

Dr. Cliona Rooney’s research interests are immunotherapies for virus and non-virus-associated malignancies and diseases. In protocols developed with Dr. Helen Heslop, Dr. Malcolm Brenner, Dr. Stephen Gottschalk and Dr. Catherine Bollard, about 150 patients have received EBV or antigen-specific cytotoxic T-cells. These have prevented and cured EBV-associated lymphoma in BMT recipients produced mixed tumor responses, including complete remissions in patients with relapsed EBV-positive Hodgkin’s disease and nasopharyngeal carcinoma and have produced clinical remission in chronic-active EBV infections.

In the research laboratory, she is developing methods for the activation and expansion of antigen-specific CTLs for the treatment of non-viral cancers, investigating ways to render CTL resistant to immune evasion strategies used by tumor cells to grow in an immunocompetent host and developing means to induce antigen-specific tolerance.

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Interested Topics

Pediatrics, Hematology-Oncology, Molecular Virology, Microbiology, Immunology, Immunotherapies for Virus and Non-Virus-Associated Malignancies, EBV, Antigen-Specific Cytotoxic T-cells, Treatment of Non-Viral Cancers, Induction of Antigen-Specific Tolerance

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