Cigall Kadoch BA, PhD

Cigall Kadoch is an institute member of the Broad Institute and an assistant professor of pediatric oncology at the Dana-Farber Cancer Institute and Harvard Medical School. Kadoch studies chromatin regulation, with a strong focus on the structure and function of the mammalian SWI/SNF or BAF family of chromatin remodeling complexes in human cancer. Her work has been centered on mechanistically interrogating rare, molecularly well-defined cancers, to understand the role these complexes play in promoting a wide range of more common cancer types.

Kadoch completed her graduate and postdoctoral research at the Stanford University School of Medicine. Working alongside renowned developmental biologist Gerald Crabtree, she used a series of biochemical experiments in combination with data-mining to identify a novel set of proteins, components of the mSWI/SNF or BAF complex, which regulates chromatin structure in cells. Kadoch and her colleagues were able to link mutations in molecular subunits of the BAF complex to more than one-fifth of human cancers.