Chrysothemis Brown MA, MBBS, PhD

Chrysothemis Brown, MBBS, Ph.D., is a Parker Senior Fellow at Memorial Sloan Kettering Cancer Center (MSKCC), New York. She is an Assistant Member in the Human Oncology Pathogenesis Program and Developmental Oncology Division, MSKCC, and an Assistant Attending in the Department of Pediatrics, Memorial Sloan Kettering Hospital. Brown received her MD from Oxford University, UK, and completed her medical training in Pediatrics in London. She obtained her Ph.D. in Immunology under the mentorship of Randy Noelle, studying transcriptional and epigenetic regulation of T cell fate. For her post-doctoral research, Brown joined the lab of Alexander Rudensky a Wellcome Trust Clinical Research Fellow to pursue studies in the transcriptional regulation of immune cell fate. There she discovered novel dendritic cell subsets, both in mice and humans.

Brown now leads her own lab at MSKCC. The lab’s research goals include decoding the environmental cues that shape dendritic cell heterogeneity in the tumor environment and determining the role these different dendritic cells play in tumor growth, metastasis, and tumor immunity. The Brown lab approaches these questions using a combination of genetically engineered mouse models, single-cell genomics, and cutting-edge spatial analyses. A further major effort of the lab is to map the development of the pediatric immune system, in order to translate studies of dendritic cell heterogeneity into therapeutic approaches for both adult and pediatric solid tumors.