Chad Brenner PhD

Dr. Brenner is an assistant professor in the Department of Otolaryngology-Head and Neck Surgery. He is also a member of the U-M Comprehensive Cancer Center. His lab, the Michigan Otolaryngology and Translational Oncology lab (MiOTO), aims to identify new diagnostic tests and precision medicine therapies for cancer patients.In addition to receiving his undergraduate degree in biomedical engineering from the University of Michigan, Dr. Brenner also received a master's in engineering in bioelectrical engineering and a doctorate in cellular and molecular biology for his seminal contributions to molecular mechanisms of prostate cancer progression and therapeutic inhibition of the disease.

His publications are as follows:
Brenner JC*, Ateeq B*, Li Y, Yocum AK, Cao Q, Asangani IA, Patel S, Liang H, Yu J, Palanisamy N, Siddiqui J, Yan W, Wang X, Cao X, Mehra R, Basrur V, Lonigro RJ, Yang J, Tomlins SA, Maher CA, Elenitoba-Johnson KSJ, Hussain M, Navone NM, Pienta KJ, Varambally S, Feng FY, Chinnaiyan AM. Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion Positive Prostate Cancer. Cancer Cell. 2011; 19(5):664-78. PMID:21575865 / PMCID:PMC3113473.
Brenner JC*, Feng FY*, Han S, Patel S, Goyal SV, Bou-Maroun LM, Liu M, Lonigro R, Prensner JR, Tomlins SA, Chinnaiyan AM. PARP-1 Inhibition as a Targeted Strategy in Ewing’s Sarcoma. Cancer Res. 2012; 72(7):1608-1613. PMID:22287547/ PMCID:PMC3319786.
Brenner JC, Chinnaiyan AM. Disruptive events in the life of prostate cancer. Cancer Cell. 2011; 19(3):301-303. PMID:21397854.
Prensner JR*, Iyer MK*, Balbin OA, Dhanasekaran SM, Cao Q, Brenner JC, Asangani I, Grasso C, Kominsky HD, Cao X, Jing X, Siddiqui J, Wei JT, Palanisamy N, Robinson D, Iyer HK, Maher CA, Chinnaiyan AM. Transcriptome sequencing identifies PCAT-1, a novel lincRNA implicated in prostate cancer progression. Nat Biotechnol. 2011; 29(8):742-749. PMID:21804560 / PMCID:PMC3152676.
Grasso CS, Wu YM, Robinson DR, Cao X, Dhanasekaran SM, Khan AP, Quist MJ, Jing X, Lonigro RJ, Brenner JC, Asangani IA, Ateeq B, Chun SY, Siddiqui J, Sam L, Anstett M, Mehra R, Prensner JR, Palanisamy N, Ryslik GA, Vandin F, Raphael BJ, Kunju LP, Rhodes DR, Pienta KJ, Chinnaiyan AM, Tomlins SA. The mutational landscape of lethal castration-resistant prostate cancer. Nature. 2012; 487(7406):239-243. PMID:22722839 / PMCID:PMC3396711 .
Cao Q, Mani RS, Ateeq B, Dhanasekaran SM, Asangani IA, Yu J, Kim JH, Prensner JR, Brenner JC, Cao X, Jing X, Wang R, Li Y, Dahiya A, Wang L, Lonigro RJ, Tomlins SA, Palanisamy N, Maher CA, Varambally S, Chinnaiyan AM. Coordinated regulation of polycomb group complexes through microRNAs in cancer. Cancer Cell. 2011; 20(2):187-199. PMID:21840484 / PMCID:PMC3157014.