Casey A. Maguire PhD

Casey A. Maguire obtained his B.S. from the University of Maine in 2000 and his Ph.D. from the Department of Microbiology and Immunology at the University of Rochester School of Medicine and Dentistry in 2006. He was a postdoctoral fellow at Massachusetts General Hospital from 2006 to 2010. He was next an Instructor from 2010 to 2013. He is currently an Assistant Professor of Neurology at Harvard Medical School with laboratory space at MGH.

His laboratory focuses on developing effective gene delivery vehicles for in vivo gene therapy of various genetic diseases, including Alzheimer’s disease. The current focus of the Maguire lab is the development of a unique hybrid gene delivery system called vexosomes. Vexosomes are endogenously enveloped adeno-associated virus (AAV) vectors. The envelope is derived from extracellular vesicles (EVs), which are natural lipid-based nanoparticles released by cells. We have shown that EVs have several properties that enhance AAV-mediated gene delivery.