Brett A. Kaufman PhD

Dr. Kaufman is working as an Assistant Professor at the University of Pittsburgh. Dr. Kaufman’s long-standing research interest is to understand the contribution of mtDNA metabolism to disease progression. He has been uncovering the fundamental processes that underlie mitochondrial respiratory deficiency with a focus on mtDNA stability and copy number control – processes essential for respiratory function and viability. Dr. Kaufman’s major research goals are to define the biochemical events responsible for the maintenance of mtDNA content, to understand how distinct pathways influence mtDNA maintenance, and to understand the mechanisms of mtDNA damage and resistance to damage in the context of disease.