Dr Anselm Mak commenced his advanced physician training in Rheumatology and Internal Medicine in Hong Kong in 2003 after he graduated in MBBS from the University of Hong Kong in 1998 and obtained the MRCP(UK) in 2002. After completing his specialist training in December 2005, Dr Mak joined the NUH as a rheumatologist in September 2006. Dr Mak has been a consultant with the Division of Rheumatology since July 2009. He was elected Fellowship of the Royal College of Physicians, Edinburgh, and Fellowship of the Royal College of Physicians, Ireland, in 2009 and 2014 respectively.
On the academic side, Dr Mak joined the NUS Clinician Scientist track in April 2008 and was subsequently awarded tenure with the university. Dr Mak's major research areas include mechanism of early lupus-related damage in major organs, and immunopathogenesis of lupus nephritis and neuropsychiatric lupus. His recent major discoveries are the involvement of specific neural circuits in subclinical cognitive dysfunction related to SLE (Systemic Lupus Erythematosus), the association between bone loss, inflammation and endothelial dysfunction in lupus, as well as disease activity-related oxidative stress in lupus lymphocytes. In the coming few years, Dr Mak will focus on addressing the neuropathology of lupus-related cognitive impairment using resting-state and event-related functional MR imaging, and the role of 4-1BBL in the pathogenesis of SLE. His work has been published in a number of rheumatology journals including Rheumatology (Oxford), Arthritis & Rheumatism and Nature Reviews Rheumatology. Based on his original clinical and laboratory observation between 2007 and 2011, he defended his doctoral thesis entitled "Major Organ Damage in Systemic Lupus Erythematosus" which awarded him the higher doctorate from his alma mater in November 2012.
Dr Mak is the Associate Editor of the International Journal of Rheumatic Diseases (ISI Impact Factor 2013: 1.77), and he is a regular reviewer of a number of international peer-reviewed journals including the Annals of the Rheumatic Diseases, American Journal of Kidney Disease, British Journal of Psychiatry, Circulation: Cardiovascular Imaging, Kidney International, Rheumatology (Oxford), Arthritis Care and Research, Journal of Rheumatology and Lupus.
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