Ann Ager PhD

Ann Ager was after gaining a PhD from Cambridge University studying inflammatory responses in vascular endothelial cells, Dr Ager moved to Professor Judah Folkman’s laboratory at Harvard to train in microvascular endothelial cell biology. She then moved to Professor Bill Ford’s laboratory in Manchester to study the regulation of lymphocyte trafficking by high endothelial venules (HEV) where she gained a non-clinical MRC Senior Fellowship before moving to the MRC National Institute for Medical Research. The focus of the Ager lab has been the molecular basis of lymphocyte-HEV recognition. This has resulted in a body of work based on a tractable in vitro model of lymphocyte-HEV recognition and studies of lymphocyte trafficking and immune responses in genetically modified mice developed by Dr Ager. A major focus has been the regulation of Lselectin expression and its impact on physiological and pathological T cell trafficking in virus infection, cancer, and, more recently, Alzheimer's disease.