Pfaltz's early research was influenced by his PhD supervisor Albert Eschenmoser and was largely based around the synthesis of corrins,[3] porphyrins[4] and other macrocycles. During the second half of the 1980s he began to use fragments of these macrocycles as novel ligands for asymmetric catalysis, with chiral C2-symmetric semicorrins being the most successful example.[5][6] Following the development of structurally related bis(oxazoline)s Pfaltz began using and developing various oxazoline based ligands, making significant contributions to the known chemistry of phosphinooxazolines.[7][8] His current research activities remain focused on ligand development, asymmetric catalysis and catalyst screening.