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Home  >  Speakers  >  Andrea Califano
Andrea Califano

Andrea Califano

    PhD
Chair, Director, Professor | New York, New York    United States of America
Cell And Developmental Biology, Molecular Biology
Molecular Biology, Computational Biology,...More
Spoken at 1 event
Speaking at 1 event

Biography :

Andrea Califano, Dr., is a pioneer in the field of systems biology and founding chair of the Department of Systems Biology at Columbia University Irving Medical Center. A physicist by training, Dr. Califano has taken innovative, systematic approaches to identify the molecular factors that lead to cancer progression and to the emergence of drug resistance at the single-cell level. Directing the conversation about cancer research away from focusing solely on gene mutations, Dr. Califano examines the complex and tumor-specific molecular interaction networks that determine cancer cell behavior.

Using information-theoretic approaches, analysis of these networks can precisely pinpoint master regulator proteins that are mechanistically responsible for supporting tumorigenesis and for implementing tumor cell homeostasis. Dr. Califano and his lab have shown that master regulators represent critical drivers and tumor dependencies, despite the fact that they are rarely mutated or differentially expressed, thus establishing them as a bona fide new class of therapeutic targets.

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Specialties

Cell and Developmental Biology, Molecular Biology

Interested Topics

Molecular Biology, Computational Biology, Cancer Cell Behavior, Tumorigenesis, Tumor Cell Homeostasis, Cell Biology, Systems Biology, Cancer Research

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Languages

English

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