Amanda received her PhD from the University of Birmingham, where she took a particular interest in the biogenesis of secreted virulence determinants from Gram-negative pathogens. In 2011, Amanda began post-doctoral work focusing on the applications of these bacterial secretion systems as a platform for vaccine delivery, using attenuated Salmonella strains.
In 2013, Amanda was awarded a Sir Henry Wellcome Fellowship to study the mechanisms of immunosuppressive bacterial antigens, in the context of chronic bacterial infections, such as Salmonella spp. and Helicobacter pylori. During the first year of the fellowship, Amanda undertook a research visit to Monash University, in Melbourne to work with a murine model of H. pylori infection; the pathogen that is the leading cause of gastric cancer.
In 2014, Amanda returned to the University of Birmingham to establish one of very few H. pylori mouse models in the UK, to study the balance between chronic bacterial infections, immunomodulation and gastric cancer.
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