Aline Bozec PhD

Prof. Dr. rer. nat. Aline Bozec obtained her PhD degree in Biochemistry in 2004 from the University Claude Bernard Lyon 1, where she worked on the effects of in utero exposure to environmental factors as endocrine disruptors on male fertility. In 2005, she joined E. Wagner’s Laboratory at the Research Institute of Molecular Pathology (IMP) in Vienna (Austria). Her research focuses on the fundamental aspects of AP-1 transcription factors on bone biology. She moved to the CNIO in 2008 as a Staff scientist in E. Wagner’s Laboratory, BBVA Foundation – CNIO Cancer Cell Biology Programme.

Since 2012, he joined the Medizinische Klinik 3-Rheumatologie und Immunologie in Erlangen (Germany) as junior professor (Emmy Noether grant) in Osteoimmunologie and then in 2019 a full professor in experimental immune therapy. Her group particularly focused on crosstalk between metabolism, bone homeostasis, and inflammation.

The main research focus of the Bozec Lab is to elucidate the cellular and molecular mechanisms altering the bone marrow under disease challenges such as rheumatoid arthritis, osteoporosis, and cancer metastasis. Using in vitro and in vivo gain and loss-of-function murine models, she uncovered very important roles of the immune system in the differentiation of bone cell types such as osteoclasts and osteoblasts. Currently, we are describing the molecular mechanism by which i) altered transcription factor signaling in immune cells affects adaptive immunity and inflammation, and ii) how hypoxia-inducible factors in B-cells control autoimmunity, infection, and bone metastasis.