Alexandra Mazharian PhD

Dr. Alexandra Mazharian obtained her Ph.D. in 2007 in Blood cell Biology from the University Denis-Diderot, Paris 7, investigating the role of MAPKs in platelet activation. Her Ph.D. thesis was under the supervision of Dr. Marijke Bryckaert at the Cardiovascular Research center of Lariboisiere in Paris. She then undertook postdoctoral training in the laboratory of Prof Steve Watson at the University of Birmingham, UK, investigating novel signaling mechanisms regulating megakaryocyte development, migration, and platelet production. She also investigated the molecular basis of thrombocytopenia and hemorrhaging caused by the Src family kinase inhibitor Dasatinib, used in the treatment of chronic myeloid leukemia. In 2011, Dr. Mazharian joined the laboratory of Prof Yotis Senis as a postdoctoral fellow, at the University of Birmingham, UK, investigating the functional roles of the novel platelet ITIM-containing receptor G6b-B and the structurally-related protein-tyrosine phosphatases Shp1 and Shp2 in megakaryopoiesis. In 2013, Alexandra was awarded a British Heart Foundation Project Grant investigating the regulation of megakaryocyte and platelet hyperactivity and prothrombotic activity by the ITIM-containing collagen receptor LAIR-1 and PECAM-1. In 2015, Dr. Mazharian was awarded a British Heart Foundation Intermediate Basic Science Research Fellowship to investigate the regulation of the MAPKs Erk1/2 in platelets by the dual-specificity phosphatases (DUSP) 1 and 6 in megakaryopoiesis and platelet production.