Adilla Warris MD, PhD
Dr. Adilia Warris’s primary research area is the host-fungus interaction in specific patient groups. Over the recent years our work has provided us with new concepts and hypotheses concerning fungal pathogenesis in patients with Chronic Granulomatous Disease (CGD). Invasive infections by A. nidulans are exclusively seen in patients with this particular primary immunodeficiency disorder and behave more aggressively and result in higher mortality rates. The phenotype of A. nidulans with regards to its interaction with CGD phagocytes is clearly different from A. fumigatus, being the most common cause of invasive aspergillosis in other susceptible patient groups.
Her current research is directed at the unravelling of the molecular mechanisms underlying the hyperinflammation mounted by the CGD host upon encountering A. nidulans, to define the involvement of specific pathogen associate molecular patterns (PAMPs) and to characterize the systems involved in the innate recognition of this pathogen. A thorough knowledge of the underlying pathogenesis is urgently needed to improve patient management.