Animal Models of Cancer Conference: From Cancer Genetics to Precision Oncology is organized by Fusion Conferences Ltd and will be held from Nov 03 - 06, 2021 at Dolce CampoReal Lisboa, Lisbon, Portugal. Target Audience: • Basic scientists studying all aspects of cancer biology • Scientists and clinicians performing translational work, especially those using mouse models for preclinical studies • Investigators from the biotech and pharma industries who are interested in state-of-the-art animal modeling approaches Description: The first genetically engineered mice were created more than 40 years ago. Since then, steady improvements in the field have allowed for the generation of experimentally controllable and genetically accurate models for many human cancers. Recent technological advances in genome editing are pushing this frontier and new animal models are directly impacting precision medicine approaches by enabling the functional evaluation of larger numbers of genetic and epigenetic alterations, by providing pre-clinical and co-clinical platforms to evaluate new therapies, and by allowing for the detailed study of tumor biology that cannot be approached in cell-based systems, immunocompromised animals, or patients. While animal modeling has been a staple of the cancer biology community for decades, it is only now maturing to its fullest potential. This conference will focus on three major areas: First, it will present new approaches to generate precise and complex genetic alterations in mice and other animals to better “humanize” models and allow for in vivo studies of cancer gene function. Second, it will highlight studies to investigate fundamental mechanisms of cancer initiation and progression, including the cell of origin of tumors, their evolution, their metabolism, and their interactions with the immune system. Finally, the meeting will explore how genetically engineered animal models can help evaluate the efficacy of novel therapeutic approaches and to decipher mechanisms of therapeutic resistance. Educational Need: Cancer genome sequencing provides an unprecedented view of recurrent alterations in human cancers and the development of highly effective targeted therapies and immune-modulatory therapies constitutes major victories. Nevertheless, the function of genes identified from genomic studies is often poorly characterized, leaving no means of therapeutic intervention. Moreover, cancers that are initially sensitive to therapy inevitably become resistant, often through mechanisms that are not well understood. Mouse models represent an experimental system to study cancer gene function and to evaluate the efficacy and resistance mechanisms associated with specific therapies. In the past few years, other animal models have also been instrumental in studying mechanisms of tumorigenesis. This conference will provide a forum for discussion on the past, present, and future of animal models for cancer, in particular the role that these models will play in the era of precision medicine. Key Sessions: • New technologies for cancer modelling • Modeling pre-cancers and tumor initiation • Cancer metabolism • Cancer/immune interactions and tumor microenvironment • Metastasis • Preclinical trials and resistance

15th International Society of Physical and Rehabilitation Medicine (ISPRM) World Congress is organized by International Society of Physical and Rehabilitation Medicine (ISPRM) and will be held from May 16 - 19, 2021 at Lisbon, Portugal. Additional details will be posted as soon as they are available.

21st World Congress on Dental Traumatology is organized by International Association Dental Traumatology (IADT), European Society of Endocrinology (ESE) and will be held from Jun 02 - 05, 2021 at Lisbon Congress Centre, Lisbon, Portugal. The theme of the congress is: "Challenges, Opportunities and New Horizons in Dental Trauma" Course Description: World Congresses on Dental Traumatology are universally known as extraordinary meetings that combine the diagnosis, treatment and follow up care of patients who have sustained an oral or dental traumatic injury.  The Congress will have broad appeal for a wide variety of scientists, general dentists and pre- and postgraduate students with an interest in dental traumatology. In addition, a wide range of professionals from many dental specialties including Endodontics, Oral Surgery, Paediatric Dentistry, Prosthodontics and Periodontics will greatly benefit from the presentation of the latest advances in dental traumatology. Pre-congress courses will be held on 2nd June 2021. Additional details will be posted as soon as information is available.​

ESGAR 2021 - 32nd Annual Meeting and Postgraduate Course is organized by European Society of Gastrointestinal and Abdominal Radiology (ESGAR) and will be held from Jun 15 - 18, 2021 at Congress Center Lisboa, Lisbon, Portugal.  Additional details will be posted as soon as information is available.  

6th Edition World Summit on Pediatrics is organized by BioMedia srl and will be held from Jun 17 - 20, 2021 at SANA Metropolitan Hotel, Lisbon, Portugal. Through a variety of state-of-the-art sessions, keynote lectures, roundtable discussions, workshops and sessions including oral and poster presentations, the congress theme will underpin the need for collaboration and cooperation of individuals from a wide range of professional backgrounds; it will provide a wonderful forum for you to upgrade your knowledge and explore the innovations in Pediatrics. This exciting congress will bring together researchers, clinicians and other healthcare professionals in an international forum, enabling the exchange of the latest advances in both science and practice, within the research and clinical community; the Congress will strive to offer plenty of networking opportunities, providing you with the opportunity to meet and interact with the leading scientists and researchers, friends and colleagues as well as sponsors and exhibitors. Additional details will be posted as soon as information is available.

3rd Chromosomal Instability as a Driver of Human Disease Conference is organized by Fusion Conferences Ltd and will be held from Oct 04 - 07, 2021 at Dolce CampoReal Lisboa, Lisbon, Portugal. Target Audience: This meeting will appeal to Molecular/Cell Biologists/Geneticists & Biochemists interested in genome stability. Researchers interested in the molecular basis of cancer, neurodegenerative diseases and ageing and those with an interest in high throughput genetic and pharmacological screening methods will also find the conference highly relevant along with those wishing to exploit genome maintenance abnormalities in tumour cells for therapeutic benefit. Synopsis: This conference is a continuation of the DNA Replication as a Source of DNA Damage series. The maintenance of genome integrity is critical for the suppression of several pathological disorders in humans, including cancer, infertility and neurodegeneration. Moreover, the accumulation of unrepaired errors in DNA is commonly cited as a likely cause of tissue and organismal ageing. Destabilization of the genome can occur as a result of several cell intrinsic or extrinsic factors, including errors arising during DNA replication or chromosome segregation, as well as exposure of cells to agents that induce DNA damage. In this conference, we aim to bring together scientists studying DNA replication, DNA repair and chromosome segregation with those interested in how chromosomal instability can influence human pathology. Moreover, we aim to show how high throughput and high content screening methods can be used as a discovery tool both for basic science applications and to identify potential therapeutic modalities. Key Sessions: • Pathways for repair of DNA damage and disrupted DNA replication forks • Screening tools for analysis of genome maintenance pathways and for development of new therapeutics • Chromosome fragility caused by difficult-to-replicate loci – sources and roles of DNA repair proteins • Chromosome instability as a driver of tumorigenesis, neurodegeneration and ageing • Exploitation of defects in chromosome maintenance in cancer treatment Educational Need: Chromosome instability is involved in several human diseases and is a feature of natural ageing. This conference will bridge fundamental studies on the mechanisms by which cells maintain genome stability with applications of these studies aimed at the development of new therapies. Hence, the conference will bridge basic biology and clinical applications in this rapidly advancing field. Attendees should be able to obtain a full picture of the current status of the field, as well as to interact with prominent research leaders driving the clinical application of the latest research.

Intestinal Stem Cell - Niche Interactions in Health and Disease Conference is organized by Fusion Conferences Ltd and will be held from Oct 07 - 10, 2021 at Dolce CampoReal Lisboa, Lisbon, Portugal. Target Audience: Scientists and physicians from the fields of stem cell biology, gastrointestinal disease, metabolic disorders, or immunology who are interested in integrating concepts across these areas to improve understanding of mechanisms underlying intestinal homeostasis, disease, and disease treatment. Key Sessions:  Inflammation: causes and consequence • Microbiome  • Metabolism and Aging • Modeling the intestine in vitro • Intestinal diseases and ISCs  • Plasticity in the intestine • Regulation of ISC behavior Synopsis: The past ten years have seen an explosion of information regarding intestinal stem cells (ISCs), due to an improved ability to identify ISCs, follow their fates, and manipulate ISCs in vitro. The next frontier in the ISC field is understanding the role that dysregulated ISC behavior plays in the etiology of disease, and conversely, the impact of intestinal disease on proper ISC function. This meeting will bring together a diverse group of investigators to discuss topics such as how the environment of the small intestine and colon impacts ISC behavior in healthy and diseased states, how ISC behavior and the niche differ along the proximal-distal axis of the intestine, and the strengths of various models for investigating the relationship between ISCs, the niche, and the onset and propagation of disease states. Educational Need: There does not appear to be any other conference which focuses entirely on intestinal stem cell biology in the context of multiple disease states and in a variety of organisms. In the conference, we will discuss topics such as: • Novel methods for assessing stem cell growth and differentiation capabilities from along the intestinal tract • Discussing the extent to which mouse studies can faithfully model human disease, and what are the limits • The impact of inflammation (disease, infection) on ISC proliferation and differentiation capacity • The impact of diet and metabolism on ISC behaviour from different regions of the small and large intestine • The impact of aging on ISCs from different regions of the small and large intestine

European Society for Emergency Medicine (EUSEM) Congress 2021 is organized by European Society for Emergency Medicine (EUSEM) and will be held from Oct 27 - 31, 2021 at Lisbon Congress Centre, Lisbon, Portugal. Additional details will be posted as soon as information is available.

2nd Fusion Conference on Ubiquitin Function in Health and Disease is organized by Fusion Conferences Ltd and will be held from Oct 31 - Nov 03, 2021 at Dolce CampoReal Lisbon, Lisbon, Portugal. Target Audience: This conference will appeal to researchers who are particularly interested in the diverse functions of the ubiquitin system, rather than structural aspects of it, as well the way this system is involved in normal physiology in a whole range of pathologies that have been shown to be associated with abnormal ubiquitin signalling. Naturally this target profile will bring together researchers from both academia and the biotech/pharma industries who want to be on top of the most recent developments in this fascinating and fast developing field. Learning Objectives: • To be on top of the field with regards to the diverse functions of the ubiquitin system • To comprehend how the ubiquitin system affects health and disease • To understand the therapeutic opportunities provided through our increased knowledge of ubiquitin’s functions  • To learn which ubiquitin-related drug candidates are presently in preclinical and clinical development and in which clinical entities they are tested • To develop a sense for fruitful future research directions and therapeutic opportunities offered by the study of ubiquitin function Additional details will be posted as soon as information is available.

40th Congress of the European Society of Surgical Oncology is organized by European Society of Surgical Oncology (ESSO) and will be held from Nov 08 - 10, 2021 at Lisbon Congress Centre, Lisbon, Portugal. Additional details will be posted as soon as information is available.