Malignant gliomas are the most aggressive brain tumours in the adult. Among them, the most frequent is glioblastoma multiforme (GBM), with a very low average survival, due in part, to its infiltrative nature and location. Every year in Spain, 4000 new patients are diagnosed with malignant glioma, from which one third are GBM. The low incidence of these tumours, together with their heterogeneity, hampers the successful clinical translation of the results achieved through individual projects, working with a reduced number of samples. Therefore, interdisciplinary and collaborative approaches are crucial to drive many aspects of GBM research, such as studies on tumour initiation and progression, patient stratification, identification and validation of new targets and biomarkers and, eventually, the development of new therapeutic approaches. The Spanish Glioma Network (“Red Española de Investigation en Glioblastoma”, REIG) brings together clinical and basic researchers, from both private and public institutes and hospitals, with interest on GBM. It provides a platform to create a discussion forum among the different specialists, with the main goal of promoting interdisciplinary initiatives and collaborative projects, in order to increase our knowledge of the GBM biology and to rationalize the design of better and personalized therapeutic strategies.