Precision Medicine: Evidence Based Development and Practice (10 Modules Bundle)

Date and Location of Activity: Online – On Demand, March 2022 – March 2023

Course Overview and Goals 
Precision Medicine comprises customized diagnostic and therapeutic strategies targeting patients with susceptibility to a distinct disease condition based on individualized and family genomic background, environmental effects, lifestyle habits and co-morbidities.

It is an emerging clinical field that integrates broadly validated results from investigations of molecular and genetic basis of diseases with prevention, diagnosis and treatment of the individual patient. It is also a necessary aspiration if we are to achieve a health care delivery system that can provide accessible, high-quality, and cost/effective clinical care.

While it has tremendous potential to contribute to improving outcomes and decreasing cost of treatments, there remain important challenges to its clinical implementation that need attention, including: Education of physicians for successfully transition to using Precision Medicine at their medical practice; Integrating molecular and genetic guidance into routine healthcare delivery; Securing patient engagement and trust; Regulating Laboratory Developed Tests (LDTs) and targeted therapies; Generating the evidentiary support for Precision Medicine; Data-sharing and infrastructure needs; Economics of Precision Medicine and the new business models that simultaneously reduce the cost but improve the quality of care.

On this basis, this course has been mainly designed to meet the educational needs of physicians and other healthcare providers who see patients and have the desire of understanding newest concepts, methods and procedures of Precision Medicine, its cost-effectiveness and its distinct business model, commercialization channels and reimbursement.

Program of Lectures

Educational Objectives

Module 1 - Understanding the clinical value of genes and molecules identified in the mechanism of disease. 
  - Precision Medicine background and historical hits. 
  - Principles of Molecular Medicine. 
  - Discuss basics on how our molecular composition and gene expression patterns are contributing to pathogenic and pathophysiological mechanisms of diseases and are teaching us on what is specific and targetable in each patient’s disease. 
 

Module 2 - Laboratory Technologies for Precision Medicine Development and Practice. 
  - Describe how to select and use the most appropriate laboratory technologies for practicing Precision Medicine. 
  - Explain basics on how to practice Precision Medicine with integrative clinical and multiomics data analysis. 
  - Describe how laboratory and analytical technologies are contributing to clinical biomarker development and validation. 
 

Module 3 - Transforming Genomic and Molecular Data into Diagnostic Improvements. 
  - Identify translational research models for transforming genomic and molecular biomarkers into diagnostic tools. 
  - Explain the concept and clinical development of complementary diagnostic tests. 
  - Explain the concept and clinical development of companion diagnostic tests. 
 

Module 4 - Transforming Genomic and Molecular Data into Therapeutic Improvements. 
  - State concept and main categories of molecular therapeutic targets. 
  - Identify diagnostic strategies for the clinical detecting and pharmacological study of molecular therapeutic targets 
  - Discuss how to integrate pharmacogenomics and pharmacogenetics into target-oriented therapeutics. 
 

Module 5 - Precision Medicine Development, Clinical Adoption and Healthcare organization models. 
  - Precision Medicine adoption process and deployment strategies at key clinical services of healthcare centers. 
  - Infrastructure and operating models at Precision Medicine Centers. 
  - Ethical, legal, economic, and operational issues around how molecular biomarkers, genomic data, aggregated clinical data, and patient-reported data are being brought to bear on refining diagnoses and personalizing treatments. 
 

Module 6 - IT and Business support of Precision Medicine Development 
  - Explain how computer sciences, digital healthcare and artificial intelligence are contributing to Precision Medicine’s effects on outcomes. 
  - Principles and applications of multimodal and multiscale healthcare analytics. 
  - Global landscape of Precision Medicine business and education. 
 

Module 7 - Precision Medicine: Evidence-Based Development and Practice (I. Obesity and Cardiovascular Risk Molecular Phenotyping) 
  - State molecular pathogenesis and pathophysiology of Cardiometabolic Syndrome. 
  - Clinical use and interpretation of molecular biomarkers defining obesity subtypes and their major co-morbidities. 
  - Clinical phenotypes and the molecular subtyping of patients with Cardiometabolic Syndrome. 
 

Module 8 - Precision Medicine: Evidence-Based Development and Practice (II. Immuno-inflammatory molecular profiling of Covid-19) 
  - Immuno-pathogenic mechanisms and molecular pathophysiology of COVID-19.  
  - Describe molecular pathogenesis and pathophysiology of extrapulmonary manifestations of COVID-19. 
  - COVID-19 targets across the Liver-Lung-Brain immuno-inflammatory axis. 
 

Module 9 - Precision Medicine: Evidence-Based Development and Practice (III. Prometastatic Colorectal Cancer Subtyping) 
  - Interpreting molecular and genomic data from developing malignant tumors and their tumor microenvironments to refine diagnosis and personalize cancer therapy. 
  - Molecular and genomic aspects of cancer metastasis disease and their implications on clinical outcomes of Precision Medicine practice. 
  - Discuss the clinical use of molecular and genomic biomarkers defining patients with and without prometastatic liver and colorectal cancer. 
 

Module 10 - Precision Medicine: Evidence-Based Development and Practice (IV. Immunocarcinogenesis Breast Cancer Subtyping) 
  - State biological and therapeutical aspects of breast cancer and breast cancer metastasis disease. 
  - Molecular classifications and therapeutic targets in breast cancer Precision Medicine. 
  - Describe clinical and therapeutical implications of breast cancer molecular subtyping by immune checkpoint genes and her2-regulated prometastatic genes.