BAP1 Gene Inactivation/Loss: Relevance to Skin Tumors

BAP1 Gene Inactivation/Loss: Relevance to Skin Tumors is organized by Opus Medicus, Inc.

Course Dates:
Last Review Date: 03-Dec-2024
Expiration Date: 03-Dec-2027

Description:
This course is an update on the current understanding of the BAP1 gene, its functional domains, tumor syndromes associated with loss of function germline mutations, and tumors with somatic loss of BAP1 gene expression. It concentrates on cutaneous tumors associated with BAP1 loss, their work-up, and clinical implications.

Objectives:
After taking this course, participants are expected to gain knowledge of:

• BAP1 gene and function of its product.
• Implications of germline and somatic BAP1 mutations.
• Cutaneous melanocytic lesions with loss of BAP1.

Topics:

• Characteristics of the BAP1 gene and its function.
• Germline mutations in BAP1 and associated tumor syndrome.
• Somatic mutations in BAP1 and associated tumors.
• BAP1 inactivated atypical epithelioid melanocytic tumors.
• BAP1 inactivated skin tumors and BRAF mutations.
• Behavior of BAP1-inactivated skin tumors.
• BAP1 in cellular blue nevi and melanomas mimicking cellular blue nevi.