Metabolic Syndrome Course

Metabolic Syndrome Course is organized by MediaLab, Inc.

Course Description:
This course discusses the metabolic syndrome, a diagnosis that is not associated with one particular disease, but rather the probability of developing certain diseases or disorders as a result of a combination of defined risk factors. Explanations are presented about the inter-relationship between cytokines produced by adipose tissue and metabolic syndrome risk factors. Laboratory tests that are used to detect and monitor metabolic syndrome are also discussed.

Objectives:
• Identify the risk factors for metabolic syndrome.
• List other diseases and medical complications associated with metabolic syndrome.
• Describe the impaired lipid metabolism that occurs in metabolic syndrome and how it affects carbohydrate metabolism and produces an atherogenic dyslipidemia.
• Explain the role of insulin resistance and obesity in the onset of metabolic syndrome.
• Describe the role of the laboratory in diagnosis and monitoring patients diagnosed with metabolic syndrome.
• Interpret patient information and laboratory results using the NCEP: ATP III metabolic syndrome criteria and laboratory reference ranges.
• Describe clinical treatment goals in metabolic syndrome.

Course Outline:
• Metabolic Syndrome
    • Metabolic Syndrome
    • Insulin Resistance
    • The Importance of Diagnosing Metabolic Syndrome
    • Risk Factors
    • Dyslipidemia
    • Atherogenic Dyslipidemia
    • Hypertension
    • Risk factors for metabolic syndrome include:Abdominal obesity (excessive fat in the stomach area): waist circumference greater than 35 inches/88 cm (w...
    • Which lipid group, in increased concentrations, probably decreases HDL-C and causes the formation of small dense LDL molecules?
• Adipose tissue and metabolic syndrome
    • Adipokines Significant to Insulin Resistance and Metabolic Syndrome
    • TNF-alpha
    • Interleukin-6 (IL-6)
    • Plasminogen Activator Inhibitor-1 (PAI-1)
    • Adiponectin
    • Angiotensinogen
    • Leptin
    • Resistin
    • Which adipokine is a protective adipokine that inhibits several steps in the inflammatory process, increases fatty acid oxidation, decreases liver glu...
• Medical Conditions Associated with Metabolic Syndrome
  • Type 2 Diabetes
    • Metabolic Syndrome and Type 2 Diabetes
    • An individual diagnosed with metabolic syndrome has an increased risk for developing cardiovascular disease and/or type 2 diabetes.
  • Cardiovascular Disease
    • Atherosclerosis
    • Adipokines and Atherosclerotic Inflammatory Process
    • Endothelial Dysfunction
    • What is a potential consequence of atherosclerosis?
    • Why are small dense LDL molecules more atherogenic?
  • Prothrombotic State
    • Prothrombotic State
    • Insulin resistance places an individual with metabolic syndrome at greatest risk for which of the following diseases/disorders?
  • Other Possible Medical Conditions
    • Medical Complications of Metabolic Syndrome
• Diagnosis of Metabolic Syndrome
    • Variation in Diagnostic Criteria
    • Adult Treatment Panel III and ACC/AHA Guidelines
    • NCEP: ATP III Diagnostic Criteria for Metabolic Syndrome
• Clinical Management in Metabolic Syndrome
    • Treatment
    • Magnesium, Calcium, and Vitamin D
    • Low-dose antiplatelet agents may reduce the risk of diabetes for those diagnosed with metabolic syndrome.
• Laboratory Role in Metabolic Syndrome
    • Clinical Laboratory Testing in Metabolic Syndrome
    • A 60-year-old female visits her physician for an annual physical. The female exercises regularly and eats healthy most of the time. The physician sugg...
• References
    • References