Erythrocyte Inclusions Course

Erythrocyte Inclusions Course is organized by MediaLab, Inc.

Course Overview:
This course describes and richly illustrates various erythrocyte inclusions, including basophilic stippling, Cabot rings, Pappenheimer bodies, siderotic granules, and Howell-Jolly bodies, making it productive for CE, exam reviewing, and cross training.

Objectives:
• Identify erythrocyte inclusions that may be observed on a Wright or Wright-Giemsa stained peripheral blood smear.
• Identify erythrocyte inclusions that require staining methods other than Wright or Wright-Giemsa stain to be visualized on a peripheral blood or bone marrow smear.
• Discuss the composition and formation of various erythrocyte inclusions.
• Identify diseases or disorders associated with various erythrocyte inclusions.

Course Outline
• Introduction to erythrocyte inclusions
    • What are Erythrocyte Inclusions?
    • The presence of erythrocyte inclusions may indicate the presence of disease.
• Characteristics of polychromatophilic red cells (Reticulocytes)
    • Reticulocytes
    • Normal Erythrocytes
    • Polychromatophilic Red Blood Cells (RBCs)
    • Stress Reticulocytes
    • Which of the following statements characterize a reticulocyte?
    • While performing a peripheral blood smear review, you observe the cells indicated by the arrows on this Wright-Giemsa stained slide.How would you clas...
• Characteristics of Basophilic Stippling
    • Basophilic Stippling
    • Fine Basophilic Stippling
    • Coarse Basophilic Stippling
    • What is the composition of the granules associated with basophilic stippling?
    • In which of the following disorders would you probably observe coarse basophilic stippling on a Wright-stained peripheral blood smear?
• Characteristics of Howell-Jolly Bodies
    • Howell-Jolly Bodies
    • Examples of Howell-Jolly Bodies
    • Howell-Jolly Body in Nucleated Red Cell
    • What is the composition of Howell-Jolly bodies?
    • If present, how many Howell-Jolly bodies are usually seen within a given erythrocyte?
    • In which of the following conditions would you expect to find Howell-Jolly bodies?
    • What abnormality is present in this slide?
• Characteristics of Pappenheimer bodies and Siderotic granules
    • Pappenheimer Bodies
    • Pappenheimer Bodies, continued
    • Pappenheimer Bodies, continued
    • Basophilic Stippling contrasted with Pappenheimer Bodies
    • Howell-Jolly Bodies and Pappenheimer Bodies
    • Comparison of Erythrocyte Inclusions
    • Siderotic Granules
    • Siderocytes and Ringed Sideroblasts in Bone Marrow
    • Siderocyte
    • Sideroblast
    • Match the descriptions below with the erythrocyte inclusions from the drop down box that they describe. The descriptions refer to the appearance of th...
    • Which of the following is NOT present in normal bone marrow and would be associated with a disease or disorder?
    • The inclusions that are indicated by the arrows on this Wright-Giemsa stained peripheral blood smear are most likely Pappenheimer bodies.
    • The cell that is indicated by the arrow in this Prussian-blue stained bone marrow smear is a ringed sideroblast.
• Characteristics of Cabot Rings
    • Cabot Rings
    • Cabot Rings, continued
    • Cabot Rings, continued
    • Which of the following statements best describes the appearance of Cabot rings?
    • In which of the following conditions might Cabot rings be observed in erythrocytes on a Wright-stained peripheral blood smear?
• Characteristics of Heinz bodies
    • Heinz Bodies
    • Heinz Bodies, continued
    • Heinz bodies are composed of which of the following?
    • Heinz bodies can be found in which of the following disorders?
    • Malaria and Malarial Parasites
• References
    • References