Chronic Kidney Disease Course

Chronic Kidney Disease Course is organized by MediaLab, Inc.

Course Description:
This course provides essential background on Chronic Kidney Disease (CKD) for the practicing clinical laboratorian. Emphasis is placed on the National Kidney Foundation-Kidney Disease Outcomes Quality Initiative (NKF-KDOQI) review and commentary of the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines, with focus on the laboratory testing associated with diagnosis and monitoring of the disease.

Objectives:
• Describe the frequency, risk factors, classification, and public health implications of chronic kidney disease (CKD)
• Name and describe the use of common serum and urinary biomarkers used to diagnose and evaluate CKD
• Describe the use and limitations of major calculations employed in estimating glomerular filtration rate (GFR)
• List treatment options to control progression of CKD.

Course Outline:
• Chronic Kidney Disease
    • Introduction
    • Renal Anatomy & Function
    • The Nephron
    • Chronic Kidney Disease
    • Epidemiology
    • Risk Factors
    • Match the respective:
    • Which disease or factor is the current leading cause of CKD worldwide?
    • According to KDIGO guidelines, CKD may be diagnosed if chronic abnormalities in kidney function are present for more than 3 months.
• Laboratory Testing
    • Diagnostic Tests for Chronic Kidney Disease (CKD)
  • Glomerular Filtration Rate
    • Glomerular Filtration Rate
    • Direct Measurement of the GFR
    • Direct Measurement of the GFR, continued
    • Calculated Estimates of GFR
    • Decreases in GFR may be caused by both benign and pathologic conditions.
    • Both direct measurement and indirect estimates of GFR can be performed. Which one of these is more common?
    • Creatinine
    • Demographic Effects on Creatinine Generation
    • Effects of Age on GFR
    • Measurement of Creatinine
    • Measurement of Creatinine, continued
    • Creatinine Assay Standardization
    • Which of the following factors influence creatinine concentration in individuals?
    • Match the description of the following creatinine assays. Answers may be used more than once or not at all.
    • Cystatin C
    • Creatinine Clearance
    • Cockcroft-Gault Equation
    • Modification of Diet in Renal Disease (MDRD) Equation
    • Chronic Kidney Disease - Epidemiology (CKD-EPI) Equation
    • eGFR in Children
    • Which eGFR equation is currently recommended for use by international experts?
  • Urine Albumin
    • Urine Albumin
    • Urine Albumin / Creatinine Ratio
    • Categories of Albuminuria
    • The term "microalbumin" is currently recommended for use to describe urine albumin.
    • Match the following categories of albuminuria to their respective urine albumin / creatinine ratio:
  • Clinical Assessment and Treatment
    • Clinical Assessment of Risk
    • Treatment / Therapy
    • Summary
• References
    • References