OVERVIEW

Cardiac Biomarkers is organized by MediaLab, Inc.

Objectives:
• Describe the role of cardiac biomarkers, the characteristics of a good marker of cardiac disease, and the use of cardiac biomarkers today.
• Explain atherosclerosis as an inflammatory process.
• Compare and contrast the cardiac biomarkers cTnI and cTnT.
• Discuss the utilization of CK-MB, myoglobin, and CK-isoform measurement in diagnosis of an acute myocardial infarction.
• Describe the formation of BNP and NT-ProBNP and their role as markers of congestive heart failure.
• Interpret the measurement results of cardiac biomarker assays in the diagnosis of an acute myocardial infarction and congestive heart failure.
• Explain the role of cardiac biomarkers in risk stratification of those with heart disease.

Course Outline:
• Cardiac and Vascular Disease
• Introduction
• Organizations and Agencies
• The Human Heart
• Which heart chamber pumps oxygenated blood out to the body?
• Terminology Describing Ischemic Heart Disease and Heart Failure
• Acute Coronary Syndrome
• Risk Factors for Heart Disease
• Ischemia refers to necrotic tissue caused by an infarcted blood supply.
• Congestive heart failure (CHF) ordinarily results when the left ventricular myocardium is weakened.
• Atherosclerosis
• Fibrous Cap
• Lipids
• Monitoring Lipids
• A buildup of plaque that occurs with atherosclerosis may eventually lead to which of the following events?
• Biomarkers of Cardiac Disease
• Heart Disease and Cardiac Biomarkers
• Uses of Cardiac Biomarkers
• Optimal Cardiac Biomarkers
• Current Cardiac Biomarkers
• Biomarkers of An AMI
• History
• Troponins
• Cardiac Troponin I (cTnI)
• Cardiac Troponin T (cTnT)
• Use of Troponins
• Troponin Measurement and Ranges
• Select the correct statements regarding troponins.
• CK-MB
• Myoglobin
• CK-Isoforms
• Pattern of AMI Biomarker Levels
• High-Sensitivity Troponin
• New Recommendations for hs-TnI
• Diagnosis of an Acute Myocardial Infarction (AMI)
• Biomarker Sampling
• Which of the following cardiac biomarkers can be used as a stand-alone marker, and is therefore the preferred biomarker to indicate the presence of an...
• A 62-year-old male has been brought by ambulance to the emergency department. The patient is a smoker with a history of uncontrolled hypertension. Whi...
• While driving home after work, a 45-year-old male construction worker is involved in a collision with another car. Upon arrival in the emergency depar...
• Biomarkers in CHF
• Cardiac Biomarkers and Congestive Heart Failure (CHF)
• Function of BNP
• BNP Versus NT-ProBNP
• BNP Versus NT-proBNP, continued
• BNP and NT-ProBNP Measurement and Ranges
• What is the function of the hormone, BNP?
• A 79-year-old diabetic and retired homemaker lives alone since the death of her husband 5 years ago. At age 75, she was diagnosed with an AMI and had ...
• Risk Stratification and Cardiac Biomarkers
• Risk Stratification
• Biomarkers to Identify Those at Risk for Developing Cardiac Disease
• Other Cardiac Risk Markers
• High Sensitivity C-Reactive Protein (hs-CRP)
• Use of hs-CRP, Measurement, and Ranges
• Comparisons of Concentrations of CRP and hs-CRP
• References
• References