Protein Homeostasis in Health and Disease 2026

Protein Homeostasis in Health and Disease is organized by Cold Spring Harbor Laboratory (CSHL) and will be held from Apr 21 - 25, 2026 at Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America.

Description:
Proper expression, folding, transport, and clearance of proteins are critical for cell function and organismal health. Chaperones and enzymes that post-translationally assist newly synthesized proteins help ensure that they are correctly folded and functional or are degraded. Translocation machineries, proteasomes, and autophagic activities are critical for subcellular localization and for degradation as necessary. Stress and aging challenge the robustness of these chaperone and clearance networks leading to protein mismanagement, overload, and cellular dysfunction. In humans, this is associated with the accumulation and aggregation of misfolded and aggregation-prone proteins, a feature of numerous neurodegenerative, metabolic, and oncogenic diseases.