Binding Kinetics and Mechanistic PK/PD modeling in early Drug Discovery

Binding Kinetics and Mechanistic PK/PD modeling in early Drug Discovery is organized by British Pharmacological Society (BPS) and will be held from Mar 27 - 28, 2023 at AstraZeneca PLC, Cambridge, England, United Kingdom.

Description:
The meeting will focus on the use of binding kinetics and mechanistic PK/PD modeling in informing early drug discovery decisions. Further, the deliberations will strive to delve deeper into the importance of aspects like association, dissociation, rebinding, and residence time of target-small molecule interactions. Additionally, it will shed critical light on the role of binding kinetics, target vulnerability, protein turnover, and uptake/efflux of the small molecule in modeling target occupancy metrics and, thus eventually, dosing decisions. The meeting is to be held over two days at the Discovery Centre, Cambridge. Registration for the meeting will include lunch and light refreshments on both days.

Learning outcomes:
Our expectation is that the meeting may serve:
• A special themed issue to be published from the deliberations of this meeting.
• Establishing the framework for the implementation of kinetics in drug discovery.
• Attempts at establishing guidelines on the uniform nomenclature for this field to avoid ambiguities.

Meeting topics:
This event aims to bring together established leaders and emerging investigators exploring the use of binding kinetics in guiding early drug discovery
• Small molecule-target Binding kinetics
• Mechanistic PK/PD (Pharmacokinetics/Pharmacodynamics) modeling
• Early Drug Discovery