C. elegans: From Genome Editing to Imaging

C. elegans: From Genome Editing to Imaging is organized by European Molecular Biology Laboratory - European Bioinformatics Institute (EMBL - EBI) and will be held from Mar 23 - 29, 2026 at EMBL Advanced Training Centre (ATC), Heidelberg, Baden-Wurttemberg, Germany.

Description:
C. elegans is a widely used model organism in genomics, cell biology, neurobiology, and evolution, known for its fully sequenced genome, completely mapped cell lineage, and powerful experimental tools like advanced genetics and imaging. Continuous advancements in techniques, such as genome engineering and high-resolution imaging, further enhance its utility for various disciplines. However, cutting-edge methods are often inaccessible even in established labs.

This course provides essential training for early-career researchers entering these dynamic fields and specialists seeking to expand their expertise. Through hands-on practicals, participants gain valuable experience in conducting experiments, while lectures and discussions with leading faculty highlight how these technologies address key scientific questions.

The topics of the lectures include genome organisation, cell division, development, tissue function, physiology, evolution, and environmental interactions. Practical sessions range from basic techniques, including handling, staging, and maintenance, to advanced and specialised techniques in genome editing, sample preparation, imaging, and image analysis, incorporating new methods like microfluidics-based high-throughput microscopy and analysis techniques, including AI-driven segmentation and spot detection. This course offers a stimulating learning experience, empowering researchers to fully leverage C. elegans in advancing their scientific work.