Goodbye Flat Biology: Ex Vivo to in Vivo Models of Cancer

Goodbye Flat Biology: Ex Vivo to in Vivo Models of Cancer is organized by European Association for Cancer Research (EACR) and will be held from Sep 23 - 25, 2025 at MESSE ESSEN GmbH, Essen, North Rhine-Westphalia, Germany.

Description:
The EACR Conference: Goodbye Flat Biology will focus on cancer models that span in vitro investigations to in vivo cancer biology. Emerging topics include how the extracellular matrix controls cell architecture, mechanobiology, the immune response, and how cell fate transitions underpin tissue morphogenesis and the metastatic cascade.

A tumour is a complex ecosystem involving multiple cell types, including stromal, immune, vascular, lymphatic, neuronal and epithelial cells. This complexity cannot be modelled completely using conventional 2D monocultures of tumour cells. This meeting will cover cutting-edge, multidisciplinary efforts to create models that mimic the complexity of tissue formation, tissue homeostasis, and the dysregulation of these processes during cancer. The programme includes a wide range of approaches to understand how targeting tissue dynamics may provide therapeutic intervention into cancer progression.

This edition of the conference will seek to emphasise how targeting the mechanisms that control assembly into tissues, including the interactions with multiple epithelial cell types and the immune system, affects cancer progression and treatment response.

Topics to be Covered:

• How complex cell interactions are coordinated to control tumour growth and metastasis, including cell fate transitions in tissue biology and cancer 
• Targetable roles of the extracellular matrix in cancer biology 
• Cancer immunotherapies 
  Advanced imaging technologies 
• Organoids and microtissue platforms 
• Spatial transcriptomics.