47th Annual Carrell Krusen Neuromuscular Symposium

47th Annual Carrell Krusen Neuromuscular Symposium is organized by University of Texas Southwestern (UTSW) Medical Center and will be held from Feb 20 - 21, 2025 at T. Boone Pickens Biomedical Building at UT Southwestern Medical Center, Dallas, Texas, United States of America.

Overview:
This symposium is a clinical education experience for members of multidisciplinary teams who care for patients with rare, complex neuromuscular diseases including hereditary muscular dystrophies, motor neuron disorders, peripheral autoimmune disorders (such as inflammatory myopathies, neuropathies, myasthenia gravis), and rare genetic disorders of nerve, neuromuscular junction, and muscle. Case presentations will include physical diagnosis and discussion of management and new therapies by participating experts. All discussions involve active participation by attendees. The educational format for this activity includes didactic lectures with in depth Q&A, panel discussions, and PowerPoint Presentations. The content of the program is identified and developed through a Call for Abstracts process. The 2025 keynote speaker will present a formal lecture on congenital myopathies, a group of ultra-rare, single gene disorders that he has studied for 3 decades. He has been a leader in gene discovery for these disorders and a pioneer in developing therapies.

Learning Objectives:

• Discuss genotype/phenotype correlation for the congenital myopathies. Review results of clinical trials and plans for upcoming trials. Review management aimed at quality of life.
• Discuss recent advances in the genetic diagnosis of neuromuscular disorders, in research and clinical practice and the latest developments in treatment such as gene replacement therapy, cell therapy and forms of RNA therapy.
• Identify and apply current pharmacological and non-pharmacological treatments in motor neuron diseases including gene replacement therapy.
• Recognize the clinical applications of results of imaging both MRI and ultrasound as well as histopathology in neuromuscular disorders.