Assay Guidance Workshop for High-Throughput Screening and Lead Discovery

Assay Guidance Workshop for High-Throughput Screening and Lead Discovery is organized by National Center for Advancing Translational Sciences (NCATS) and will be held from Sep 24 - 25, 2024 at Eli Lilly and Company Corporate Center, Indianapolis, Indiana, United States of America.

Description
The NCATS Assay Guidance Manual (AGM) program and Eli Lilly and Company are co-hosting a two-day workshop that will cover a broad range of critical concepts underlying assay development and implementation for high-throughput screening and lead discovery projects. This workshop is designed to disseminate critical information about the implementation of robust assay methods and is particularly relevant for researchers developing molecular probes or clinical candidates. Many of the instructors have 20 to 30 years of experience in the field of drug discovery and will share information not readily found in a classroom or published material outside of the AGM. The workshop also will cover emerging technologies and modalities in drug discovery, including the use of DNA-encoded libraries and 3-D tissue models in drug discovery.
Goals and objectives
This workshop will provide participants with a broad, practical perspective on assay development and data analysis so they can improve research projects involving drug discovery and know where to find further information; identify reagents, methods and instrumentation that are well suited to robust assays; and develop robust assays and the required counter and secondary assays for targets of interest. In addition, the workshop will provide participants with broad overviews and practical perspectives on new and emerging modalities in drug discovery.
Specific learning goals and objectives of this workshop include:

• Gain an overview of the Assay Guidance Manual ebook as an important resource for detailed information about robust assay methods and best practices in quantitative biology.
• Identify practical approaches for developing robust assays for biochemical and cell-based screening as well as the selection of optimal assay reagents and instrumentation.
• Gain an overview on biophysical approaches to small molecule discovery and validation.
• Discuss sources of assay artifacts and strategies to identify artifacts through the development and implementation of counter assays.
• Interpret important statistical and data analysis concepts with an emphasis on using these concepts to collect the best possible data and make go/no go decisions based on experimental results.
• Identify practical approaches for lead selection and optimization.
• Gain overviews and practical perspectives on new and emerging modalities in drug discovery.
• Share experiences and seek practical advice about individual research concerns.