4th Exploring DNA Repair Pathways as Targets for Cancer Therapy Conference

4th Exploring DNA Repair Pathways as Targets for Cancer Therapy Conference is organized by Fusion Conferences Ltd and will be held from Oct 07 - 10, 2024 at Hilton Malta, Saint Julian s, Northern Harbour, Malta.

Synopsis:
Defects in DNA damage repair and checkpoint control are underlying mechanisms driving tumorigenesis, since they allow for the accumulation of genetic alternations. Indeed, defects associated with these pathways are the underlying cause of several human cancer-prone syndromes. On the other hand, defects in DNA repair and checkpoint control create vulnerabilities in cancer cells that can be targeted by DNA damaging agents and inhibitors that disrupt checkpoint pathways. More recently, defective DNA repair and checkpoint regulation have been shown to influence R-loop formation, replication fork stability, and innate immunity. These new findings not only reveal additional mechanisms contributing to tumorigenesis, but also provide new targets for cancer therapy. This conference will focus on exploring these vulnerabilities, taking advantage of the synthetic lethality concept, and targeting specific DNA repair and checkpoint pathways for cancer therapy, either alone or in combination with chemotherapy, radiation therapy, targeted therapy, and immunotherapy. This conference will bring together basic, translational and clinical investigators to discuss current and future directions, opportunities and obstacles to the development of these anti-cancer modalities and how to best translate these concepts to clinical practice.

Key Sessions:

• Recent advances in the field of DNA repair, cell cycle checkpoint control, genome maintenance, and innate immunity
• Radiation therapy and immune response
• Novel targets in DNA repair and checkpoint pathways
• Explore synthetic lethality and combination therapy for cancer treatment
• Evaluate the therapeutic potential of new anti-cancer modalities and combinations
• Mechanisms underlying therapeutic resistance

Educational Need:
DNA damage repair and checkpoint control is an exciting field that has undergone tremendous growth in the past few years. While insightful new research on the molecular mechanisms that govern a variety of DNA repair and cell cycle checkpoint pathways has led to an expansion of our understanding of DNA damage response pathways in humans, it also offers new approaches for cancer prevention and treatment. The purpose of this conference is to accelerate the translation of basic research findings into clinical practice. The audience will benefit from the interactions with experts in the fields of DNA damage response, drug development and clinical trials.