Tumor Metabolism (B5) by Keystone Symposia on Molecular and Cellular Biology

Tumor Metabolism (B5) is organized by Keystone Symposia on Molecular and Cellular Biology and will be held from Feb 24 - 28, 2019 at Keystone Resort, Keystone, Colorado, United States of America.

Course Description :
Research over the past decade has considerably enhanced our understanding of metabolic changes that occur as cancers emerge from normal tissues, and it has become apparent that tumors evolve numerous mechanisms to obtain the nutrients they need to grow and to cope with the reactive oxygen species that are generated during high rates of growth. This Keystone Symposia conference will focus on approaches to identify and therapeutically exploit the various metabolic vulnerabilities of tumor cells compared to normal tissues. The major goal is to discuss how to develop new therapies to kill tumors based on emerging knowledge about metabolic vulnerabilities. As new drugs that target metabolism enter the clinic, we need biomarkers that reveal which tumors are likely to be vulnerable and biomarkers that reveal mechanisms of resistance. Specific aims are to:

•  Understand how and why different tumor types evolve different mechanisms to obtain nutrients
•  Explore how tumor cells protect themselves from reactive oxygen species
•  Investigate differences in metabolism of metastatic tumors compared to primary tumors
•  Understand how whole body metabolism relates to tumor metabolism, and
•  Enhance our ability to monitor tumor metabolism via minimally invasive imaging.

The anticipated outcomes are the sharing of unpublished discoveries about mechanisms used by primary and metastatic tumors to obtain nutrients from their environment as emerging technologies for monitoring tumor metabolism in vivo and ex vivo.

The conference will bring together scientists and clinicians with widely different backgrounds in preclinical models of cancer, drug discovery, drug development, imaging and clinical trials to share information about:
•  The diverse ways that tumors alter metabolism
•  New drug targets suggested from this knowledge of tumor metabolism
•  New technologies to monitor tumor metabolism in vivo and ex vivo
•  Progress being made in pre-clinical studies with experimental approaches that alter tumor metabolism, and
•  Progress in human clinical trials with new drugs that target metabolism.

Plenary Session Topics:
• Cancer Cell Metabolism
• Feeding the Cancer
• Metabolism and Metastasis
• The Metabolism of ROS and Survival
• Metabolism Outside the Tumor
• Metabolic Adaptation and the Response to Therapy
• Imaging Cancer Metabolism in vitro and in vivo
• Modeling Cancer Metabolism in vitro?

Additional details will be posted as soon as they are available.