The Ubiquitin System: Function, Physiology and its Role in Disease Conference

The Ubiquitin System: Function, Physiology and its Role in Disease is organized by Fusion Conferences Ltd and will be held during Jun 03 - 06, 2018 at Melia Nassau Beach All Inclusive, Nassau, New Providence, Bahamas.

The target audience for this medical event is researchers who are particularly interested in the diverse functions of the ubiquitin system, rather than structural aspects of it, as well the way this system is involved in normal physiology in a whole range of pathologies that have been shown to be associated with abnormal ubiquitin signalling. Naturally this target profile will bring together researchers from both academia and the biotech/pharma industries who want to be on top of the most recent developments in this fascinating and fast developing field.

We have reached a fascinating point in the field of ubiquitin research. The attachment of ubiquitin to a protein in the cytosol was first identified as a means to enable the degradation of this protein by the proteasome. Much later it became clear that the ubiquitin system fulfils another crucial cellular function: through the dynamics offered by ubiquitination and subsequent deubiquitination it gives signalling platforms in a plethora of signal transduction pathways the means to initiate but, importantly, also to end the triggering of particular signals originating from these platforms. Whilst some of the signalling-related functions of the ubiquitin system are mediated via its proteasome-targeting function, the majority of these are mediated by different types of ubiquitin chains acting as scaffolds for the recruitment of signalling modules to protein complexes which serve as platforms for the triggering of specific signalling complexes.

Rather than discussing mainly structural aspects of the ubiquitin system, this conference is dedicated to the study of functional roles of the ubiquitin system, how it works to ensure normal signal transduction, what are the pathological consequences when it is perturbed and how we may be able to address such perturbances therapeutically in various diseases including cancer, autoimmunity and neurodegeneration.

Learning Objectives :
• To be on top of the field with the diversity of functional roles of the ubiquitin system
• To understand how the ubiquitin system affects health and disease
• To develop an understanding for where the treatment options are currently seen in the ubiquitin fields
• To learn which ubiquitin-related drugs are presently in preclinical and clinical development
• To get a feel for the opportunities of the future provided by the ubiquitin system

Price:
Academic from : USD 1823.00,
Industry from: USD 1823.00,
Student from : USD 1534.00

Speakers: Dr. Vishva Dixit (Genentech), Prof. Henning Walczak (Cancer Research UK - UCL Centre)

Additional details will be posted as soon as they are available.