Structural Bioinformatics is organized by European Molecular Biology Laboratory - European Bioinformatics Institute (EMBL - EBI) and will be held from Sep 03 - 07, 2018 at EMBL-EBI European Bioinformatics Institute Main Building, Cambridge, England, United Kingdom.
The target audience for this medical event is for biological researchers who want to learn more about the application of structural information in their work and how to use some of the key bioinformatics resources that are available.
Overview
Structural biology, determining the three-dimensional shape of a protein, can tell us a lot about how a protein functions and the role it plays within a cell. Bioinformatics data derived from structural determination experiments can aid biological researchers asking a wide variety of questions. It aides the understanding of how DNA mutations might alter a protein’s shape, disrupt a catalytic site, or alter the binding affinity of a pharmaceutical compound.
This course explores bioinformatics data resources and tools for the interpretation and exploitation of bio-macromolecular structures. It will focus on how best to analyze available structural data to gain useful information given specific research contexts. The course content will investigate the impact of genetic variation on structure, predicting protein structure and function, and exploring interactions with other macromolecules as well as with low-MW compounds. Participants will also have an opportunity to explore protein docking using HADDOCK.
Outcomes:
• Access and browse a range of structural data repositories
• Determine whether appropriate structural information exists, applying available structure-quality information
• Build a structural model for a protein which has a structurally characterized relative and evaluates its quality
• Evaluate the potential impact of genetic variation on a structure
• Predict the function of a protein based on sequence and structure data
• Explore protein complex modeling approaches
Additional details will be posted as soon as they are available.