11th NPY-PYY-PP Meeting 2015

The neuropeptide Y (NPY) family of biologically active peptides NPY, peptide YY (PYY) and pancreatic polypeptide (PP) comprise a multi-ligand / multi-receptor system together with a set of different GPCR types known as Y1, Y2, Y4, Y5 and Y6 in mammals. This system influences a wide range of essential physiological key functions, e.g. food intake, memory retention, gastrointestinal transit, regulation of blood pressure, and is known to be associated with a variety of major human diseases such as obesity, epilepsy, mood disorders, gastrointestinal and cardiovascular complications, and cancer. Combining basic knowledge from a multidisciplinary perspective including biochemical, cellular biology, genetic, and medical aspects is a prerequisite for an improved understanding of the NPY system and exploiting its significant potential as a therapeutic target for the treatment of disorders.