Sensing and Signaling of Hypoxia: Interfaces with Biology and Medicine (A1)

Hypoxia is an important component of most human diseases. This meeting will focus on advances in the understanding of the biochemistry and biology of hypoxia signaling and their impact on cell biology, physiology and medicine. Specific emphasis will be placed on the emerging interfaces of hypoxia biology with new areas of scientific progress including metabolic regulation, epigenetic signaling, stem-cell biology, inflammation, immunity, tissue repair and cancer. The meeting will also aim to link these processes to the integrative physiology of hypoxia and act as a forum for interfacing reductionist molecular approaches with medical physiology. Key objectives are: • to report key emerging research findings in hypoxia biology across a range of biomedical research fronts • to promote and extend new areas of research into the impact of hypoxia on biological systems • to promote interdisciplinary research aimed at linking molecular and integrated physiology and defining therapeutic opportunities.