Upcoming Medical Conferences in Nassau

6th Nucleic Acids Conference is organized by Fusion Conferences Ltd and will be held during Feb 13 - 16, 2019 at Melia Nassau Beach All Inclusive, Nassau, New Providence, Bahamas. Conference Description : The key role of nucleic acids is to encode and process genetic information at a molecular level. DNA is the genetic library of the cell, while RNA transports, translates and controls the expression of that information. DNA must be copied with unprecedented accuracy once every cell cycle. It is under constant endogenous and environmental onslaught, and a variety of repair pathways are necessary to maintain the integrity of the genetic blueprint. DNA is the only cellular molecule for which repair occurs to a significant extent. DNA undergoes recombination, a kind of molecular cut and re-join that creates diversity to facilitate evolution, as well as providing an important repair pathway. In eukaryotes something like 2m DNA is packaged into chromosomes so that it packs into the cell nucleus with a diameter of just 6 µm, while remaining accessible to the cellular machinery that reads out its genetic information.  Understanding processes involving DNA and RNA at the molecular and chemical level is the central theme of this conference, with a marked structural and mechanistic perspective. The meeting will provide a platform for researchers to discover and discuss the latest advances in the field of nucleic acids, DNA and RNA, with exciting opportunities to share and receive feedback on unpublished data. Conference Topics : • DNA replication. • DNA repair. • DNA recombination. • RNA structure and function. • Translation and the ribosome. • Silencing. • CRISPR/Cas and genome editing. • Gene regulation and riboswitches. • RNA catalysis. Additional details will be posted as soon as they are available.

3rd Fibroblast Growth Factors (FGF) in Development and Repair Conference is organized by Fusion Conferences Ltd and will be held from Feb 15 - 18, 2019 at Melia Nassau Beach All Inclusive, Nassau, New Providence, Bahamas. Target Audience: FGFs are key regulators of development, repair, disease, and metabolic homeostasis for many organs and therefore, FGF researchers come from various disciplines. These include structural biologists, biochemists, cell biologists, clinical researchers, clinicians, geneticists, pharmacologists and bioengineers. FGF meetings usually attract people from academia, but also from various pharmaceutical companies due to the important roles of FGFs and FGF receptors as drug targets. Learning Objectives: We aim to bring together a diverse group of researchers with different expertise and skills in a single forum to discuss the latest results, to exchange ideas, to foster new and often interdisciplinary collaborations and to identify the major new direction of the field. Key Sessions will cover the following aspects: • FGF signalling in normal and impaired development • Role of FGFs in stem cell biology • Interaction of FGF signalling with other signalling pathways • Role of endogenous and efficacy of exogenous FGFs in tissue repair and regeneration • Role of altered FGF signalling in human diseases, ranging from rare developmental disorders to major diseases such as metabolic syndrome and cancer • Role of FGFs and FGFRs as therapeutic targets • FGFs as endocrine hormones.

Epithelial Mesenchymal Interactions in Lung Development and Fibrosis Conference is organized by Fusion Conferences Ltd and will be held from Feb 17 - 20, 2019 at Melia Nassau Beach All Inclusive, Nassau, New Providence, Bahamas. Course Description: Lung development is governed by epithelial-mesenchymal interactions. These pathways are recapitulated during injury and repair. This conference will focus on understanding key processes underlying lung development, injury and repair in the context of age, environment and species, with the hope of better understanding disease development and to discover novel therapeutic approaches. We will highlight critical issues on lung epithelial biology such as stem cells and regenerative medicine, while expanding sessions to encompass themes such as single cell analytical approaches, cell-cell communication, dissect the biological distinctions mesenchymal proliferation as a repair mechanism and fibrosis; present the impact of new tools in single-cell analysis on understanding lung development, repair, and disease; and characterize epithelial-mesenchymal interrelationships that maintain lung homeostasis and orchestrate repair and regeneration. The entire program has been designed to achieve a better understanding of the key clinical research issues and how they relate to basic mechanistic investigation. Key Sessions: • Fgf signaling in lung development and fibrosis. • Aging and lung fibrosis. • Lung stem/progenitor cells and their regulation in health and disease. • Organoid cultures to model lung development and disease. • Epithelial-mesenchymal interactions in lung development and fibrosis. Time: 2:00 pm to 12:00 pm. Speakers: Saverio Bellusci (University of Giessen), Zea Borok (Keck School of Medicine of USC), Wellington Cardoso (Columbia University), Gianni Carraro (Cedars-Sinai), Harold Chapman (University of California, San Francisco), Elie El Agha (Justus-Liebig-University Giessen), John Engelhardt (University of Iowa Carver College of Medicine), Finn Hawkins (Boston University), Brigid Hogan (Duke University), Alison Humbles (MedImmune LLC), Carla Kim (Harvard Medical School), Melanie Koenigshoff (University of Colorado Denver), Mark Krasnow (Stanford University), Maya Kumar (Stanford School of Medicine), Daniel Lafkas (Genentech), Susan Majka (Vanderbilt University), Parviz Minoo (Keck School of Medicine of USC), Edward Morrisey (University of Pennsylvania), Paul Noble (Cedars-Sinai), David Ornitz (Washington University), Anne-Karina Perl (Cincinnati Children's Hospital), Jayaraj Rajagopal (Harvard University), Emma Rawlins (University of Cambridge), Jason Rock (Boston University), Jason Spence (University of Michigan), Xin Sun (University of California, San Diego), Nan Tang (National Institute of Biological Sciences), Victor Thannickal (University of Alabama at Birmingham), David Warburton (Keck School of Medicine of USC), Rui Zhao (Novartis) Additional details will be posted as soon as they are available.

3rd Small Molecule Activation Conference is organized by Fusion Conferences Ltd and will be held from Feb 19 - 22, 2019 at Melia Nassau Beach All Inclusive, Nassau, New Providence, Bahamas. Conference Description: Small molecules are constituents of the air we breathe (e.g. N2, O2, CO2) and take part in element cycles and various metabolic processes. Further representatives (e.g. H2, CO, CH4) are produced/converted in nature under anaerobic conditions or in industrial processes on large scales. Hence, small molecules such as those mentioned are readily accessible and comparatively inexpensive, so that it is highly desirable to include them into syntheses of value-added products or to use them as reservoirs of chemical energy (fuels). However, at the same time they are typically quite thermodynamically stable, so that their utilization requires an activation step. The topic of this conference will thus be concerned with various aspects of small molecule activation, with a focus on molecular insights. It provides a stimulating and interdisciplinary environment for both senior scientists and young researchers to discuss latest progress in the field. Prices: Academic from: USD 1822.0, Industry from: USD 1822.0, Student from: USD 1533.0 Time: 2:00 pm to 12:00 pm Speakers: Mu-Hyun Baik (KAIST), Marcetta Darensbourg (Texas AandM University), William Evans (University of California Irvine), Karsten Meyer (Friedrich Alexander University Erlangen-Nürnberg), Oliver Einsle (University of Freiburg), Alan Goldman (Rutgers University), Osamu Ishitani (Tokyo Institute of Technology), Daniel Stack (Stanford University), David Milstein (Weizmann Institute of Science) Additional details will be posted as soon as they are available.

Internal Medicine for Primary Care: Cardio/Neuro/Onc/Rheum is organized by Medical Education Resources (MER) and will be held from Feb 21 - 24, 2019 at Atlantis Paradise Island Resort, Nassau, New Providence, Bahamas. The target audience for this medical event is office-based primary care providers and other health professionals with updates in primary care medicine. This CME Conference has been approved for a maximum of 16.00 AMA PRA Category 1 Credits. Learning Objectives are : Upon completion of this program, participants should be better able to: • Describe current diagnostic approaches to arrhythmias, hypertension, ACS and CAD • Implement treatment strategies reflective of current evidence-based medicine for arrhythmias, hypertension, ACS and CAD • Evaluate and treat fibromyalgia • Utilize current evidence to design treatment strategies for inflammatory arthritis and osteoarthritis • Perform a neurological exam as well as distinguish signs of weakness and other neurological disorders • Describe the differential diagnosis and treatment of movement disorders • Discuss the approach and subsequent therapeutic management of the cancer patient, as well as the cancer survivor

4th Drug Discovery Re-Invented Conference is organized by Fusion Conferences Ltd and will be held from Feb 21 - 24, 2019 at Melia Nassau Beach All Inclusive, Nassau, New Providence, Bahamas. Conference Description: The fourth Drug Discovery Re-Invented Meeting brings together experts in medicinal chemistry, structure-based drug design, computational chemistry, emerging drug targets, and novel technology platforms. The meeting is extremely interactive with enthusiastic question and answer sessions following each talk. This meeting remains unique with respect to the breadth of participants and focuses on new approaches to discovering drugs. With large pharma reducing investment in internal early-stage research, drug pipelines will increasingly be filled by alternative sources. These players include: government, academic labs, non-profits, biotech companies, and pharmaceutical "open innovation" models. Key Sessions: • New Approaches in Biotech, Academia, and Pharma. • New Screening Technologies and Drug Targets. • Structure, Modeling, and Fragment-based Design. • Government and Non-profit Sector in Drug Discovery and Development. • Importance of CROs in Supporting the Virtual Drug Discovery Model. • Emerging Pharmacological Targets. • Industry Exhibit. Time:14:00 to 12:00 Speakers: Vicky Steadman (Selcia Ltd), Jay Wrobel (FCCDC), Andrew Cole (Arbutus Bio), Vicki Feher (Schrodinger), Ted Price (Cercis Therapeutics), Christopher Savile (Intrexon), Bart DeCorte (Merachem), Matt Todd (Blumberg Institute) Additional details will be posted as soon as they are available.

3rd Exploring DNA Repair Pathways as Targets for Cancer Therapy Conference is organized by Fusion Conferences Ltd and will be held during Feb 23 - 26, 2019 at Melia Nassau Beach All Inclusive, Nassau, New Providence, Bahamas. Conference Description : Defect in DNA damage repair and checkpoint control is the underlying mechanism for tumorigenesis, since it allows the accumulation of multiple genetic alternations, which are essential for the initiation of tumorigenesis. This has been clearly illustrated to be the cause of several human cancer-prone syndromes and also revealed by recent human genome studies. On the other hand, defective DNA repair and checkpoint activation also make cancer cells more vulnerable for particular DNA damaging agents or inhibitors that specifically disrupt some of these checkpoint pathways. With the increasing understanding of defects in DNA repair and checkpoint control in tumorigenesis, there are extensive interests in exploring these deficiencies, especially taking advantage of the synthetic lethality concept and targeting particular DNA repair and checkpoint pathways for cancer therapy. The purpose of this conference is to bring together basic, translational and clinical investigators and discuss the current and future directions, opportunities and obstacles in the development of these anti-cancer modalities and how to best apply these concepts in clinical practice. Key Sessions : • Highlight recent advances in the field of DNA damage repair. • Identify novel targets in DNA repair and checkpoint pathways. • Explore the concept of synthetic lethality for cancer treatment. • Assess the therapeutic potential of new anti-cancer modalities. • Learn mechanisms of therapeutic resistance and ways to improve cancer therapy. Additional details will be posted as soon as they are available.

Spatial Genome Organization Conference is organized by Fusion Conferences Ltd and will be held from Feb 25 - 28, 2019 at Melia Nassau Beach All Inclusive, Nassau, New Providence, Bahamas. Target Audience : This conference should be of interest to individuals seeking to understand the basic principles of spatial genome organization and how the disruption of this organization impacts health and disease. Those interested in learning or developing new technologies that help reveal more of the secrets of spatial genome organization should both benefit from and greatly enrich the conference. Attendees are expected to have a background in the basics of genetics, nuclear organization, microscopy, and sequencing. Conference Description : The conference will bring together scientists working to better understand three-dimensional genome organization in various organisms, tissues, and cell states. Key Sessions : • Structure and function of subnuclear domains. • Topogically Associated Domains (TADs) and similar domains. • Signalling cues, cellular states and genome organization. • DNA damage and spatial genome organization. • Genome structure in health and disease. • Workshop I: Genome editing and super-resolution microscopy. • Workshop II: Chromosome conformation capture, sequencing and databases. • Workshop III: Young scientists in the era of spatial genome organization, how to get published? Speakers: Andrés Aguilera (University of Seville), Tom Misteli (National Cancer Institute), Daniel Durocher (The Lunenfeld-Tanenbaum Research Institute), Peter Fraser (The Babraham Institute), Wendy Bickmore (The University of Edinburgh) Additional details will be posted as soon as they are available.

Mitochondria: From Basic Biology to Mechanisms of Disease Conference is organized by Fusion Conferences Ltd and will be held from Feb 27 - Mar 02, 2019 at Melia Nassau Beach All Inclusive, Nassau, New Providence, Bahamas. Target Audience : • Basic scientists studying mechanisms of mitochondrial and cell biology. • Clinicians and translational biologists interested in mitochondrial disease. • Neuroscientists studying mitochondrial function and role of mitochondria in neurodegenerative disease. • Scientists studying processes where mitochondria are important (metabolism, aging, cancer, heart function, etc.) Conference Description : Mitochondria act at the interface of numerous processes critical for cellular function and organismal health. Long recognized as the powerhouses of the cell, recent years have seen a growing appreciation for the diverse roles that mitochondria play not only in energy production and metabolism, but also in maintenance of redox balance, regulation of gene expression, ion homeostasis, and control of cell fate. Mitochondrial maintenance is critical for proper function of cells and tissues, and mitochondrial dysfunction underlies numerous disease processes ranging from severe childhood mitochondrial disorders, to heart disease, neurodegenerative disorders, cancer, and aging itself. This conference will bring together scientists and clinicians with expertise in a breadth of mitochondrial biology to explore topics at the interface of basic and translational biology. Mitochondrial basic mechanisms of organelle regulation, mitochondrial mechanisms of disease, cutting edge technologies, and interventional strategies will be emphasized. Conference Objectives are : • Basic mechanisms and regulation of mitochondrial biology. • Discuss crosstalk and integration of mitochondrial pathways with other cellular compartments and cell signalling. • Learn about how these pathways of mitochondrial dysfunction contribute to diseases. • Discuss therapies targeting mitochondria in human diseases. • Discuss future directions for mitochondrial research. Speakers: Johan Auwerx (Ecole Polytechnique Federale de Lausanne), Nika Danial (Dana-Farber Cancer Institute / Harvard Medical School), Jose Antonio Enriquez (CNIC), Lydia Finley (Memorial Sloan Kettering Cancer Center), Steven Gross (Weill Cornell Medical College), Cole Haynes (University of Massachusetts Medical School), Isha Jain (University of California, San Francisco), Leanne Jones (University of California, Los Angeles), Thomas Langer (University of Cologne), Heidi McBride (McGill University), Jodi Nunnari (University of California, Davis), Philipp Scherer (The University of Texas Southwestern Medical Center), Luca Scorrano (University of Padova), Gerald Shadel (The Salk Institute for Biological Studies), Anu Suomalainen-War-tiovaara (University of Helsinki), Eileen White (Rutgers Cancer Institute of New Jersey) Time: 2:00 pm to 12:00 pm Additional details will be posted as soon as they are available.

3rd Interventions in Aging Conference is organized by Fusion Conferences Ltd and will be held during Mar 03 - 06, 2019 at Melia Nassau Beach All Inclusive, Nassau, New Providence, Bahamas. The target audience for this medical event is Basic scientists in the field of aging research using animal models., Human researchers interested in biomarkers of aging, Clinical trials specialists in aging and associated diseases., Scientists and other professionals developing aging interventions., Investors looking to enter this new space, Educated public. Conference Description : A plethora of genetic, dietary and pharmacological interventions can extend healthy lifespan in laboratory animals, and can delay or ameliorate diverse aging-related diseases. Many of the signalling pathways involved are evolutionarily conserved, and are starting to be implicated in human aging. This raises the intriguing possibility of performing preventative medicine against the chronic diseases of our time by targeting the main risk factor for all of them, namely aging. Two important current challenges in the field are : • to understand the downstream pathways by which longevity interventions combat age-related loss of function and pathology, and • to translate the findings into the extension of human healthspan. Conference Objectives are : • Identify and understand translational approaches to extend human healthspan • Understand emergent areas of research in aging • Obtain an advanced view on the molecular biology and genetics of aging • Understand for profit approaches to mitigate human aging Scientific chairs: Linda Partridge (University College London) and Brian Kennedy (The Buck Institute for Research on Aging) Speakers: Shin-ichiro Imai (Washington University in St. Louis), Darren Baker (Mayo Clinic), Janet Lord (University of Birmingham), Joan Mannick (Restorbio), Aleksandra Trifunovic (University of Cologne), Dennis Villareal (Baylor College of Medicine) Additional details will be posted as soon as they are available.