Mayo Clinic Talks Podcast: Opioid Edition is organized by Mayo Clinic School of Continuous Professional Development (MCSCPD). Course opens: 01/04/2018 Course expires: 12/31/2020 Accreditation: Mayo Clinic College of Medicine and Science designates this live activity for a maximum of 3.00 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Activity Description This is a three-hour long podcast series - (10) episodes - that are interviews recorded for self-paced listening. Mayo Clinic physicians discuss the new opioid prescribing guidelines and share real-life examples from their practice. The topics include assessing the patient’s candidacy for opioid therapy, and when deemed appropriate, what drug, duration and dose is recommended. Addiction and opioid use disorder are also discussed. Learning Objectives: Upon completion of this program, learners should be able to: • Identify when it is appropriate to initiate or continue opioid therapy for a patient. • Select the best opioid medication, dosage, and duration for a patient identified as a good candidate for opioid therapy. • Recognize the risks of opioid therapy and recommend treatment options for opioid use disorder. • Recall non-pharmacological and implantable device alternatives for the treatment of pain and ongoing pain management.

Mayo Clinic Talks Podcast - Online is organized by Mayo Clinic. Course opens: 12/30/2019 Course expires: 12/29/2022 Available credit:  • 36.75 AMA PRA Category 1 Credit™ • 36.75 Attendance Overview: Mayo Clinic Talks is a weekly podcast show hosted by Darryl Chutka, M.D., a general internist at Mayo Clinic. Podcasting offers succinct, relevant, and accessible CME. The episodes in this course reflect commonly seen health problems in a primary care practice. Listen in as Dr. Chutka interviews experts on a variety of topics ranging from The Risks and Benefits of Coffee to Transgender Patient Care, back pain, management of sleep apnea, hormone therapy, and The Dangers of Distraction and Balancing Connectivity. Listen in the course or using your favorite podcast app, then return here to take a short assessment and claim credit. Learning Objectives: Upon completion of this course, learners should be able to: • Describe the current treatment recommendations for patients with hyperlipidemia. • List the various categories of hypertension. • Describe the current pharmacologic treatment available for patients with osteoporosis. • Participation in this Mayo Clinic online course does not indicate nor guarantee competence or proficiency in the performance of any procedures which may be discussed or taught in this course.

Treatment Advances in Gastrointestinal Stromal Tumor With Shreyaskumar Patel, MD is organized by i3 Health. Release: July 10, 2020 Expiration: July 9, 2021 Accreditation: Physicians i3 Health designates this enduring activity for a maximum of 0.25 AMA PRA Category 1 Credits™.  Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 0.25 Medical Knowledge MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity.  Nursing Continuing Professional Development A maximum of 0.25 contact hours may be earned by learners who successfully complete this nursing continuing professional development activity. This activity has been designated for 0.25 contact hours of pharmacotherapy credit for Advanced Practice Registered Nurses.  Overview: The fact that gastrointestinal stromal tumor (GIST) is a rare tumor type, with an estimated incidence of 3,300 to 6,000 new cases per year in the United States, can make it more challenging for oncologists and other members of the cancer care team to stay up to date on the latest therapeutic developments. Treatment for GIST has seen exciting progress this year, with two new FDA approvals for metastatic disease. This episode of Oncology Data Advisor features Dr. Shreyaskumar Patel, Robert R. Herring Distinguished Professor of Cancer Research and Center Medical Director of the Sarcoma Center at the University of Texas MD Anderson Cancer Center in Houston, Texas, in a discussion that covers the changing treatment landscape, adverse events of concern with novel therapies, and advice for members of the cancer care team as they seek to optimize outcomes for patients with GIST. Learning Objectives: Upon completion of this activity, participants should be able to: • Evaluate emerging data on later-line treatment selection for individual patients with GIST • Apply strategies to manage adverse events related to novel GIST treatments Note: The learning objectives listed above apply to nurse practitioners and registered nurses in addition to physicians.

Optimizing Patient Outcomes in Pancreatic Cancer With Al B. Benson, MD, FACP, FASCO is organized by i3 Health. Release: August 20, 2020 Expiration: August 19, 2021 Accreditation: Physicians: i3 Health designates this enduring activity for a maximum of 0.25 AMA PRA Category 1 Credits™.  Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 0.25 Medical Knowledge MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. Physician Assistants: American Academy of Physician Assistants (AAPA) accepts certificates of participation for educational activities approved for AMA PRA Category 1 Credit™ from organizations accredited by ACCME. Physician assistants may receive a maximum of 0.25 hours of Category 1 credit for completing this program. Description: With 5-year survival rates of only 37% for local disease, 12% for regional disease, and 3% for distant disease, pancreatic cancer is one of the most aggressive forms of cancer and one of the most challenging to treat. Despite the development of novel treatment approaches, therapeutic options remain limited. In this episode of Oncology Data Advisor, Al B. Benson, MD, Professor of Medicine at Northwestern University’s Feinberg School of Medicine and Associate Director for Cooperative Groups at Northwestern’s Robert H. Lurie Comprehensive Cancer Center, joins i3 Health for a discussion that covers recent developments in genomic testing and targeted therapies, supportive care measures that can optimize quality of life, and strategies that members of the cancer care team can utilize to improve the outcomes of their patients with pancreatic cancer. Learning Objectives: Upon completion of this activity, participants should be able to: • Identify the role that biomarkers can play in predicting therapeutic efficacy and developing tailored approaches to treatment • Develop effective multidisciplinary approaches that can be used to enhance pancreatic cancer treatment and supportive care https://www.i3health.com/oda-pancreatic Faculty: Al B. Benson, MD, FACP, FASCO, Professor of Medicine, Northwestern University Feinberg School of Medicine

Novel Treatment Options in Mantle Cell Lymphoma With Gilles Salles, MD, PhD is organized by i3 Health. Release: September 18, 2020 Expiration: September 17, 2021 Accreditation: Physicians: i3 Health designates this enduring activity for a maximum of 0.25 AMA PRA Category 1 Credits™.  Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 0.25 Medical Knowledge MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. Physician Assistants: American Academy of Physician Assistants (AAPA) accepts certificates of participation for educational activities approved for AMA PRA Category 1 Credit™ from organizations accredited by ACCME. Physician assistants may receive a maximum of 0.25 hours of Category 1 credit for completing this program. Description: An aggressive form of B-cell non-Hodgkin lymphoma, mantle cell lymphoma (MCL) is a challenging disease to treat, with a median overall survival of 6 to 7 years. Even in patients who achieve a complete response, recurrence and relapse are still frequent. In this episode of Oncology Data Advisor, Gilles Salles, MD, PhD, Chief of the Lymphoma Service at Memorial Sloan Kettering Cancer Center, joins i3 Health for a discussion that covers the efficacy of newly developed Bruton tyrosine kinase (BTK) inhibitor and chimeric antigen receptor (CAR) T-cell therapies, the management of adverse events associated with these treatments, updates on ongoing research, and advice for clinicians as they seek to optimize outcomes for patients with MCL. Learning Objectives: Upon completion of this activity, participants should be able to: • Assess efficacy and safety of novel BTK inhibitor therapy for MCL • Assess efficacy and safety of CAR T-cell therapy for MCL Faculty: Gilles Salles, MD, PhD Chief of the Lymphoma Service Memorial Sloan Kettering Cancer Center

How Adolescent Boys’ Need for Friendship Affects Their Mental Health is organized by American Medical Association (AMA). Recorded Date: Nov 01, 2017 End Date: Nov 01, 2020 Duration: Clinical Review Audio 37 min 52 sec Accreditation: MOC/CME Information: 0.5 Credit CME Description: Adolescent boys are notoriously difficult to deal with. However, some of their behaviors mask a need they have for developing intimate friendships. Being adolescent boys living in a macho culture, many deny that they need these relationships. Niobe Way, EdD, professor of Developmental Psychology at New York University, has spent her professional career studying adolescent boys’ relationships with each other and how they affect their behaviors. She explains how to intervene to help them better understand their needs for intimacy, which, in turn, helps them to better relate with people and avoid unpleasant behaviors. Educational Objective: •  To understand how adolescent boys' friendships affect their mental health. Additional details will be posted as soon as information is available.

Mendelian Randomization: How the Natural Assortment of Genes Can Mimic Randomized Clinical Trials is organized by American Medical Association (AMA). Recorded Date: Nov 21, 2017 End Date: Nov 21, 2020 Duration: Clinical Review Audio 29 min 34 sec Accreditation: MOC/CME Information: 0.5 Credit CME Description: The best evidence for proving cause-and-effect comes from randomized clinical trials. However, they are expensive and difficult to perform. The natural assortment of gene variants at birth can mimic randomization in some circumstances and yield important clinical information that can help physicians better care for their patients. Educational Objective: •  To understand how mendelian randomization works and can be used to explain clinical outcomes. Additional details will be posted as soon as information is available.

Matching Drugs to Genetic Abnormalities to Precisely Treat Cystic Fibrosis is organized by American Medical Association (AMA). Recorded Date: Dec 05, 2017 End Date: Dec 05, 2020 Duration: Clinical Review Audio 26 min 07 sec Accreditation: MOC/CME Information: 0.5 Credit CME Description: Cystic fibrosis is a common autosomal recessive disease. It is caused by any one of many discrete genetic abnormalities that affect chloride transport. Identification of specific genetic abnormalities enables clinicians to identify drugs that counteract the effects of the abnormal genes. In this podcast we review how genetic defects that cause cystic fibrosis are identified and how drugs that are likely to successfully treat the disease are matched to those genetic abnormalities. Educational Objective: •  To understand the pathogenesis of cystic fibrosis and its treatment. Additional details will be posted as soon as information is available.

Diagnosis and First-Line Treatment of Chronic Sinusitis is organized by American Medical Association (AMA). Recorded Date: Dec 19, 2017 End Date: Dec 19, 2020 Duration: Clinical Review Audio 30 min 23 sec Accreditation: MOC/CME Information: 0.5 Credit CME Description: Sinusitis is one of the most common conditions seen by clinicians. Despite its frequency, it is often misdiagnosed. In this podcast, we review the proper way to establish a diagnosis and treat both acute and chronic sinusitis. Educational Objective: •  To review the proper way to establish a diagnosis and treat both acute and chronic sinusitis. Additional details will be posted as soon as information is available.

What to Do When There Is an Overdose of Insulin is organized by American Medical Association (AMA). Recorded Date: Dec 26, 2017 End Date: Dec 26, 2020 Duration: Clinical Review Audio 32 min 05 sec Accreditation: MOC/CME Information: 0.5 Credit CME Description: It is very easy to confuse drug concentrations and vials containing different amounts of drugs in the hospital setting. It is not uncommon to have dosing errors occur. In this podcast, we discuss how to manage an overdose of insulin and also how to implement preventive measures in the hospital environment to minimize the risk of drug dosing errors. Educational Objective: •  To understand how to manage insulin overdose and minimize the risk of having it occur. Additional details will be posted as soon as information is available.