Larry A. Sklar PhD

Dr. Sklar was recruited to New Mexico to direct the National Flow Cytometry Resource at Los Alamos and to develop a biotechnology research program at the University of New Mexico. From 1990-2002 he served as Director or Co-Director of the P41 National Flow Cytometry Resource at Los Alamos (P41RR01315) with responsibilities in research, collaboration, service, training, and dissemination. Beginning in 1998, Sklar led a team of colleagues in the development of high throughput flow cytometry for signal transduction and drug discovery. This work began as an NIH-funded Bioengineering Research Partnership (BRP GM60799/EB00264), which was funded in the inaugural year of that NIH program and brought together cell and molecular biology, biophysics, instrumentation hardware and software and microfluidics. This team was involved in discovery research that involved membrane steroid receptors of the G protein-coupled receptor (GPCR) class and has discovered small molecules that differentiate the classical nuclear estrogen receptors from the novel membrane estrogen receptors. The team has also developed real-time methods to examine affinity, avidity and conformation of integrin receptors involved in cell adhesion (R01 HL08162).