Jessica CataldiBA, PhD
Dr. John Castle is Associate Vice President, Head of Translational Sciences, at Agenus, Inc. Dr. Castle has deep expertise in biomarkers and therapy development using computational immunology, bioinformatics, biotechnology, and genomics. Having built translational bioinformatics and genomics units focused on immunotherapies, Dr. Castle pioneered computational approaches to identify immunogenic peptides for anti-tumor immunity. His bioinformatics approach has revolutionized Agenus’ neoantigen vaccine platform, now in Phase 1 clinical testing. Prior to joining Agenus, he served as associate director at Rosetta Inpharmatics/Merck & Co. and subsequently served as the co-director at the Biomarker Development Center of Translational Oncology at the University of Mainz, Germany. Dr. Castle was the director of bioinformatics at BioNTech AG (DE).