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MONTHLY BRIEFINGS - Sep 2017

September 2017 Briefing - Pharmacy

Mon, Oct 2, 2017

Here are what the editors at HealthDay consider to be the most important developments in Pharmacy for September 2017. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Embezzlement Widespread in Medical Practices

FRIDAY, Sept. 29, 2017 (HealthDay News) -- Embezzlement is widespread among medical practices, and knowing the warning signs is helpful for preventing it, according to an article published in Medical Economics.

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Secukinumab Effective for Moderate/Severe Scalp Psoriasis

FRIDAY, Sept. 29, 2017 (HealthDay News) -- Secukinumab is safe and effective as a treatment for patients with extensive moderate-to-severe scalp psoriasis, according to a study published in the October issue of the Journal of the American Academy of Dermatology.

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Pioglitazone Improves Left Ventricular Diastolic Function

FRIDAY, Sept. 29, 2017 (HealthDay News) -- Pioglitazone improves whole-body and myocardial insulin sensitivity, left ventricular (LV) diastolic function, and systolic function in patients with type 2 diabetes, according to a small study published online Sept. 22 in Diabetes Care.

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Checkpoint Inhibitors No Less Safe With Radiation

FRIDAY, Sept. 29, 2017 (HealthDay News) -- Immune-related adverse events (IRAEs), including pneumonitis, are not more common in patients with metastatic lung cancer who receive both immune checkpoint inhibitors (CPIs) and thoracic radiotherapy (TRT), according to a research letter published online Sept. 28 in JAMA Oncology.

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Supplements Don't Measurably Increase Macular Pigment Density

FRIDAY, Sept. 29, 2017 (HealthDay News) -- Dietary supplementation does not lead to measurable increases in macular pigment optical density, according to a study published online Sept. 28 in JAMA Ophthalmology.

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Vi-Tetanus Toxoid Conjugate Vaccine Can Prevent Typhoid

FRIDAY, Sept. 29, 2017 (HealthDay News) -- A Vi-tetanus toxoid conjugate vaccine is efficacious for prevention of typhoid fever, according to a study published online Sept. 28 in The Lancet.

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Propranolol Use Inversely Linked to Melanoma Recurrence

THURSDAY, Sept. 28, 2017 (HealthDay News) -- For patients with melanoma, use of propranolol is associated with reduced risk of recurrence, according to a study published online Sept. 28 in JAMA Oncology.

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Immune Checkpoint Inhibitor Endocrine Dysfunction Explored

THURSDAY, Sept. 28, 2017 (HealthDay News) -- Patients receiving immune checkpoint inhibitor (ICI) regimens may experience endocrine dysfunction, with increased risk of thyroid dysfunction and hypophysitis for patients on combination therapy, according to a review published online Sept. 28 in JAMA Oncology.

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More Than 78 Percent of Health Care Personnel Receive Flu Shot

THURSDAY, Sept. 28, 2017 (HealthDay News) -- More than 78 percent of health care personnel (HCP) and 53.6 percent of pregnant women received influenza vaccination during the 2016-2017 influenza season, according to two studies published in the Sept. 29 issue of Morbidity and Mortality Weekly Report.

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Optimal Length of Post-Op Opioid Pain Medication Rx Identified

THURSDAY, Sept. 28, 2017 (HealthDay News) -- The optimal length of opioid pain medication prescription after common surgical procedures lies between the observed median prescription length and the early nadir, according to a study published online Sept. 27 in JAMA Surgery.

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Psychosocial Intervention Ups Adherence to Antidepressants

THURSDAY, Sept. 28, 2017 (HealthDay News) -- A psychosocial intervention can improve early adherence to antidepressants among middle-aged and older adults, according to a study published online Sept. 27 in JAMA Psychiatry.

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FDA: New Glucose Monitoring System Eliminates Finger Pricks

THURSDAY, Sept. 28, 2017 (HealthDay News) -- The FreeStyle Libre Flash Glucose Monitoring System has been approved by the U.S. Food and Drug Administration, making it the first sanctioned device to monitor blood glucose in adult patients with diabetes without the need for a finger prick.

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Treatment of Buccinator With Botox Is Safe, Effective

THURSDAY, Sept. 28, 2017 (HealthDay News) -- Treatment of the buccinator muscle with botulinum toxin is safe and effective, and three commercially available botulinum toxin neuromodulators are similar for treatment of facial synkinesis, according to two studies published online Sept. 28 in JAMA Facial Plastic Surgery.

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About Half of Patients Receive Approval for PCSK9i Prescription

WEDNESDAY, Sept. 27, 2017 (HealthDay News) -- Fewer than half of patients prescribed PCSK9 inhibitors (PCSK9i) receive approval, and only about 30 percent ever receive therapy, according to a study published online Sept. 27 in JAMA Cardiology.

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Pneumococcal Vaccine for Only Half With Work-Related Asthma

WEDNESDAY, Sept. 27, 2017 (HealthDay News) -- Adults with work-related asthma are more likely that those with non-work-related asthma to have received pneumococcal vaccination, although only 53.7 percent with work-related asthma have been vaccinated, according to a study published online Sept. 27 in the American Journal of Preventive Medicine.

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Notification Rates of New HIV Diagnoses Up in Older Adults

WEDNESDAY, Sept. 27, 2017 (HealthDay News) -- Notification rates of new HIV diagnoses in older adults increased in 16 European countries from 2004 to 2015, according to a study published online Sept. 26 in The Lancet HIV.

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Individualized SBP Tx Cuts Risk for Post-Op Organ Dysfunction

WEDNESDAY, Sept. 27, 2017 (HealthDay News) -- Management targeting an individualized systolic blood pressure (SBP) is associated with reduced risk of organ dysfunction among patients undergoing major surgery who are at increased risk of postoperative complications, according to a study published in the Sept. 26 issue of the Journal of the American Medical Association.

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VA Models Provide Guidance for Care of Hepatitis C Infection

WEDNESDAY, Sept. 27, 2017 (HealthDay News) -- The U.S. Department of Veterans Affairs (VA) has developed models of care that can be used to reduce the overall burden of hepatitis C virus (HCV) infection, according to a study published online Sept. 25 in the Annals of Internal Medicine.

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Genotype-Guided Warfarin Dosing Cuts Adverse Events

TUESDAY, Sept. 26, 2017 (HealthDay News) -- Genotype-guided warfarin dosing is associated with reduced risk of adverse events compared with clinically-guided dosing among patients undergoing elective hip or knee arthroplasty, according to a study published in the Sept. 26 issue of the Journal of the American Medical Association.

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CDC Launches Campaign to Fight Prescription Opioid Epidemic

TUESDAY, Sept. 26, 2017 (HealthDay News) -- The U.S. Centers for Disease Control and Prevention is launching a communication campaign featuring accounts of people recovering from opioid use disorder, and those who have lost someone to opioid overdose, in an effort to fight the prescription overdose epidemic.

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Liraglutide Linked to Reduction in VAT, Improvement in β-Index

TUESDAY, Sept. 26, 2017 (HealthDay News) -- For obese individuals with prediabetes or early type 2 diabetes, liraglutide is associated with a greater reduction in visceral adipose tissue (VAT) and greater improvement in β-index, according to a study published online Sept. 14 in Diabetes Care.

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Systemic Corticosteroids Discouraged for Atopic Dermatitis

TUESDAY, Sept. 26, 2017 (HealthDay News) -- Routine use of systemic corticosteroids is generally discouraged for atopic dermatitis, according to research published online Sept. 2 in the British Journal of Dermatology.

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CYPC19*17 Allele May Influence Response to PPI Treatment

TUESDAY, Sept. 26, 2017 (HealthDay News) -- Children with CYP2C19*17 alleles without corresponding loss-of-function alleles have longer times with pH <4 in response to proton pump inhibitor (PPI) medication, according to a study published online Sept. 8 in the Journal of Clinical Pharmacology.

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Adjuvant Chemo Beneficial in Advanced Gastroesophageal CA

TUESDAY, Sept. 26, 2017 (HealthDay News) -- Adjuvant chemotherapy is associated with improved survival for patients with locally-advanced gastroesophageal adenocarcinoma treated with preoperative chemoradiotherapy and resection, according to a study published online Sept. 21 in JAMA Oncology.

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Discontinuing Low-Dose Aspirin Ups Cardiovascular Risk

MONDAY, Sept. 25, 2017 (HealthDay News) -- There is more than a 30 percent increased risk of cardiovascular events following discontinuation of low-dose aspirin in long-term users, according to a study published in the Sept 26 issue of Circulation.

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Bacillus Calmette-Guérin Vaccine May Reduce Atopic Dermatitis

MONDAY, Sept. 25, 2017 (HealthDay News) -- Bacillus Calmette-Guérin (BCG) vaccination within seven days of birth may reduce the risk of allergic diseases, including atopic dermatitis, according to a study published online Sept. 20 in Allergy.

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Worker Contribution to Health Benefits Up in 2017

MONDAY, Sept. 25, 2017 (HealthDay News) -- In 2017, health benefits coverage remained stable, while workers faced considerable variation in costs, according to a report published online Sept. 19 in Health Affairs.

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Tibetan Yoga Improves Sleep Quality During Chemo

MONDAY, Sept. 25, 2017 (HealthDay News) -- Participation in a Tibetan yoga program (TYP) during chemotherapy results in modest, short-term benefits in sleep quality, with long-term benefits seen over time for those who practice at least two times a week, according to a study published online Sept. 20 in Cancer.

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Diabetes Treatment Failure May Actually Be Nonadherence

FRIDAY, Sept. 22, 2017 (HealthDay News) -- Apparent diabetes treatment failures may in fact be attributable to nonadherence, according to a study published online Sept. 15 in Diabetes Care.

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Few Older Patients Aware of Deprescribing

FRIDAY, Sept. 22, 2017 (HealthDay News) -- The majority of older patients are aware of medication harms, but far fewer understand deprescribing, according to a brief report published online Sept. 15 in the Journal of the American Geriatrics Society.

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Nonadherence to Statins + ACEIs/ARBs Risky Post MI

FRIDAY, Sept. 22, 2017 (HealthDay News) -- Nonadherence to angiotensin-converting enzyme (ACE) inhibitors/angiotensin II receptor blockers (ARBs) and/or statins following acute myocardial infarction (AMI) is associated with higher mortality, according to study published in the Sept. 26 issue of the Journal of the American College of Cardiology.

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Fasting Blood Glucose Trajectory May Predict Future MI

FRIDAY, Sept. 22, 2017 (HealthDay News) -- For individuals without diabetes, certain fasting blood glucose (FBG) trajectories are associated with the risk of future myocardial infarction (MI), according to a study published online Sept. 8 in Diabetes Care.

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Opioid Rx, Dosing Often Excessive in Dialysis Patients

FRIDAY, Sept. 22, 2017 (HealthDay News) -- Hemodialysis patients in the United States have high rates of prescriptions for opioids and many also receive high doses of the potentially addictive drugs, according to a study published online Sept. 21 in the Journal of the American Society of Nephrology.

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Montelukast Associated With Nightmares, Depression

THURSDAY, Sept. 21, 2017 (HealthDay News) -- Montelukast appears to be linked to neuropsychiatric side effects, such as depression, aggression, nightmares, and headaches, according to a review published online Sept. 20 in Pharmacology Research and Perspectives.

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Oral Beats Topical Isotretinoin for Treatment of Warts

THURSDAY, Sept. 21, 2017 (HealthDay News) -- Oral isotretinoin shows a better and earlier response than topical isotretinoin for the treatment of plane warts, according to a small study published online Sept. 13 in the International Journal of Dermatology.

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Intradiscal Electrothermal Therapy Cost-Effective

THURSDAY, Sept. 21, 2017 (HealthDay News) -- For patients with discogenic low back pain, intradiscal electrothermal therapy (IDET) is an effective and cost-effective treatment alternative to circumferential lumbar fusion with femoral ring allograft (FRA), according to a study published online Sept. 12 in PAIN Practice.

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Combination Strategy Could Be Key in HIV Prevention

THURSDAY, Sept. 21, 2017 (HealthDay News) -- A combination antibody strategy could be the key to halting the spread of HIV, according to results from two experimental studies. The research was published Sept. 20 in Science and Science Translational Medicine.

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Highest Adverse Effect Rates for Three Drugs in Parkinson's

THURSDAY, Sept. 21, 2017 (HealthDay News) -- Ropinirole, bromocriptine, and piribedil are associated with the highest incidence rates of adverse effects in Parkinson's disease, according to a review published online Sept. 4 in CNS Neuroscience & Therapeutics.

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Long-Acting Erythropoiesis Agents Can Help Save Resources

THURSDAY, Sept. 21, 2017 (HealthDay News) -- Switching from short- to long-acting erythropoiesis-stimulating agents (ESAs) in patients undergoing hemodialysis (HD) leads to a large reduction in time and subsequent costs, according to a study published online Sept. 12 in the Journal of Renal Care.

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More Than 1 in 10 Patients May Be Overtreated for Diabetes

THURSDAY, Sept. 21, 2017 (HealthDay News) -- Medicare recipients are more frequently overtreated than undertreated for diabetes, and those who are overtreated rarely have their regimens deintensified, according to a study published online Sept. 13 in the Journal of General Internal Medicine.

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Insurer Market Power Lowers Providers' Prices

WEDNESDAY, Sept. 20, 2017 (HealthDay News) -- Insurers have the bargaining power to reduce provider prices in highly concentrated provider markets, according to a report published in the September issue of Health Affairs.

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Naloxegol Has No Effect on Opioid Dose in Opioid-Tied Constipation

WEDNESDAY, Sept. 20, 2017 (HealthDay News) -- For patients with noncancer pain and opioid-induced constipation (OIC), naloxegol has no clinically relevant effect on patient-reported pain levels or mean daily opioid dose, according to research published online Sept. 12 in PAIN Practice.

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Proton Pump Inhibitors Overused Worldwide

WEDNESDAY, Sept. 20, 2017 (HealthDay News) -- Proton pump inhibitors (PPIs) are overused worldwide, with wide variation seen in the extent of inappropriate use, according to research published online Sept. 11 in the Journal of Clinical Pharmacy and Therapeutics.

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Pioglitazone Has Limited Effect in Lipoatrophic Diabetes

WEDNESDAY, Sept. 20, 2017 (HealthDay News) -- Pioglitazone may not be effective for lowering blood glucose levels, although it is associated with slight improvement in liver function, in lipoatrophic diabetes induced by juvenile dermatomyositis, according to a case report published online Sept. 12 in the Journal of Diabetes Investigation.

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Total of 0.21 Years Lost Due to Opioid-Related Poisoning Deaths

TUESDAY, Sept. 19, 2017 (HealthDay News) -- From 2000 to 2015, drug-poisoning deaths contributed a loss of 0.28 years in life expectancy, according to a research letter published in the Sept. 19 issue of the Journal of the American Medical Association.

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Multicomponent Intervention Linked to Greater Drop in BP

TUESDAY, Sept. 19, 2017 (HealthDay News) -- A multicomponent intervention is associated with greater reduction in systolic and diastolic blood pressure (BP) than usual care over 18 months, according to a study published in the Sept. 19 issue of the Journal of the American Medical Association.

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Post-C-Section Cephalexin, Metronidazole Cuts SSI Rate

TUESDAY, Sept. 19, 2017 (HealthDay News) -- For obese women undergoing cesarean delivery, a postoperative 48-hour course of cephalexin and metronidazole reduces the rate of surgical site infection (SSI) within 30 days compared with placebo, according to a study published in the Sept. 19 issue of the Journal of the American Medical Association.

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Half of Repeat Antibiotics in Australia Extend Initial Rx

TUESDAY, Sept. 19, 2017 (HealthDay News) -- Half of repeat antibiotic dispensings in Australia are used to extend the initial course, according to a study published online Sept. 11 in the Journal of Pharmacy Practice and Research.

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Anagliptin Effect on LDL in T2DM Via ApoB-100 Synthesis

TUESDAY, Sept. 19, 2017 (HealthDay News) -- In patients with type 2 diabetes being treated with a dipeptidyl peptidase-4 inhibitor (DPP4-I), use of anagliptin (ANA) may improve low-density lipoprotein cholesterol (LDL-C) levels, with the effect mediated, at least partly, via suppression of apoB-100 synthesis, according to a study published online Aug. 29 in the Journal of Diabetes Investigation.

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Extended Thromboprophylaxis Safe, Effective After Liver Surgery

TUESDAY, Sept. 19, 2017 (HealthDay News) -- For patients undergoing liver surgery, extended pharmacologic thromboprophylaxis appears effective and safe, according to a study published online Aug. 28 in the Journal of Thrombosis and Haemostasis.

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Greater Benefit for Pioglitazone in High-Risk Patients Post Stroke

MONDAY, Sept. 18, 2017 (HealthDay News) -- For patients after an ischemic stroke or transient ischemic attack, pioglitazone is associated with greater benefit for those at higher risk for stroke or myocardial infarction (MI), according to a study published online Sept. 18 in JAMA Neurology.

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Closed-Loop Control Benefits T1DM in Prolonged Winter Sport

FRIDAY, Sept. 15, 2017 (HealthDay News) -- For adolescents with type 1 diabetes (T1D), a closed-loop control (CLC) system is associated with improved glycemic control and reduced exposure to hypoglycemia during prolonged exercise, cold temperatures, and high altitude, according to a study published online Aug. 30 in Diabetes Care.

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Lower Mortality Risk Seen With Statin Use in Older Men

FRIDAY, Sept. 15, 2017 (HealthDay News) -- Statin use is associated with a significantly lower risk of mortality in older male physicians, and a non-significant lower risk of cardiovascular disease (CVD) events, according to a study published online Sept. 11 in the Journal of the American Geriatrics Society.

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FDA Approves Aliqopa for Follicular Lymphoma

FRIDAY, Sept. 15, 2017 (HealthDay News) -- Aliqopa (copanlisib) has been approved by the U.S. Food and Drug Administration to treat adults with relapsed follicular lymphoma who have received at least two prior treatments with certain other drugs.

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'Science Spin' Found Prevalent in Biomedical Literature

FRIDAY, Sept. 15, 2017 (HealthDay News) -- Spin in biomedical literature (also referred to as "science hype") is prevalent, with trials having the highest and greatest variability in the prevalence of spin, according to a review published online Sept. 11 in PLOS Biology.

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FDA Permits Marketing of App to Help Treat Substance Abuse

THURSDAY, Sept. 14, 2017 (HealthDay News) -- The U.S. Food and Drug Administration has permitted marketing of the first mobile app to help treat substance use disorders, the agency said Thursday in a news release.

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FDA Approves First Biosimilar Drug for Cancer

THURSDAY, Sept. 14, 2017 (HealthDay News) -- The first biosimilar drug to treat cancer has been approved by the U.S. Food and Drug Administration.

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Greater Awareness Needed for Potential of T2DM Remission

THURSDAY, Sept. 14, 2017 (HealthDay News) -- For many patients with type 2 diabetes, remission can be achieved with sustained weight loss of ~15 kg, yet this often flies under the radar for patients and clinicians alike, according to an analysis published online Sept. 13 in The BMJ.

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Peri-Op IV Corticosteroids Benefit Knee, Hip Arthroplasty

THURSDAY, Sept. 14, 2017 (HealthDay News) -- Intravenous corticosteroids are both safe and effective when used perioperatively in total knee or hip arthroplasty, with benefits including less pain, vomiting, and nausea, and fewer opioids, according to a review published online Aug. 29 in PAIN Practice.

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Panic Disorder, GAD Not Linked to Adverse Pregnancy Outcomes

WEDNESDAY, Sept. 13, 2017 (HealthDay News) -- Panic disorder and generalized anxiety disorder (GAD) are not associated with adverse pregnancy outcomes, but medications can slightly shorten the duration of gestation, according to a study published online Sept. 13 in JAMA Psychiatry.

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AACR Releases 2017 Cancer Progress Report

WEDNESDAY, Sept. 13, 2017 (HealthDay News) -- The age-adjusted U.S. cancer death rate decreased 25 percent from 1991 to 2014, which translates into 2.1 million fewer cancer deaths, according to an annual progress report published by the American Association for Cancer Research.

AACR Cancer Progress Report 2017

Multivitamin Use May Cut Risk of Chemo-Induced Neuropathy

WEDNESDAY, Sept. 13, 2017 (HealthDay News) -- Multivitamin use before diagnosis of breast cancer is associated with reduced risk of symptoms of chemotherapy-induced peripheral neuropathy, according to a study published online Sept. 1 in the Journal of the National Cancer Institute.

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Vitamin D Deficiency Tied to Neuropathic Pain

WEDNESDAY, Sept. 13, 2017 (HealthDay News) -- Vitamin D deficiency may be associated with increased neuropathic pain (NP) in patients with rheumatoid arthritis (RA), according to a study published online Aug. 31 in the International Journal of Rheumatic Diseases.

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Antireflux Surgery Has High Rate of Recurrent Disease

WEDNESDAY, Sept. 13, 2017 (HealthDay News) -- Laparoscopic antireflux surgery is associated with a relatively high rate of recurrent gastroesophageal reflux disease, according to a study published in the Sept. 12 issue of the Journal of the American Medical Association.

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Hormone Therapy in Menopause Not Tied to Increased Mortality

TUESDAY, Sept. 12, 2017 (HealthDay News) -- Menopausal hormone therapy is not tied to any increase in long-term all-cause or cause-specific mortality, according to a study published in the Sept. 12 issue of the Journal of the American Medical Association.

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Warfarin, Rivaroxaban Similarly Safe, Effective

TUESDAY, Sept. 12, 2017 (HealthDay News) -- For cases of mild atrial fibrillation (AF)-related acute ischemic stroke, rivaroxaban and warfarin are similarly safe and effective at preventing recurrent stroke, according to a study published online Sept. 11 in JAMA Neurology.

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Chronic Dosing of Apricot Kernel Extract May Lead to Hypoxia

TUESDAY, Sept. 12, 2017 (HealthDay News) -- Chronic dosing of apricot kernel extract can result in hypoxia and cyanide toxicity, according to a report published online Sept. 11 in BMJ Case Reports.

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Antibiotic Rx Adherence Varies Widely in Sickle Cell Care

TUESDAY, Sept. 12, 2017 (HealthDay News) -- Adherence to antibiotic guidelines for acute chest syndrome (ACS) in children with sickle cell disease (SCD) varies widely, according to a study published online Sept. 11 in JAMA Pediatrics.

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Most Opioid Use Concentrated in Top 10 Percent of Users

TUESDAY, Sept. 12, 2017 (HealthDay News) -- The top 10 percent of privately insured U.S. adults without cancer using opioids account for most opioid use, according to a research letter published online Sept. 12 in the Annals of Internal Medicine.

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2017 Standards of Medical Care in Diabetes Released

TUESDAY, Sept. 12, 2017 (HealthDay News) -- Recommendations for the management and pharmacologic treatment of patients with diabetes have been updated; the new clinical guidelines were published online Sept. 12 in the Annals of Internal Medicine.

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Median Cost of Cancer Drug Development $648.0 Million

MONDAY, Sept. 11, 2017 (HealthDay News) -- The median cost of cancer drug development is $648.0 million, and revenue after approval is substantial, according to a study published online Sept. 11 in JAMA Internal Medicine.

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Lidocaine Nerve Block Reduces Pain During IUD Insertion

MONDAY, Sept. 11, 2017 (HealthDay News) -- A 10-mL 1 percent lidocaine paracervical nerve block reduces pain during intrauterine device (IUD) insertion, according to a study published online Sept. 5 in Obstetrics & Gynecology.

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Diverse Neurological Effects Linked to Anti-PD-1 Therapy

MONDAY, Sept. 11, 2017 (HealthDay News) -- Neurological complications associated with anti-programmed death 1 (PD-1) antibody treatment have a diverse phenotype, according to a study published online Sept. 5 in JAMA Neurology.

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Risk of Prematurity, SGA Up for Women on Antiepileptic Drugs

MONDAY, Sept. 11, 2017 (HealthDay News) -- Women on antiepileptic drugs (AEDs) during pregnancy for epilepsy or other indications are at increased risk of giving birth to premature and small-for-gestational-age (SGA) infants, according to a study published online Aug. 30 in the Annals of Neurology.

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In HIV, Tissue Factor-Expressing Monocytes Trigger Coagulation

MONDAY, Sept. 11, 2017 (HealthDay News) -- A specific subset of tissue factor (TF)-expressing monocytes persist after virological suppression and trigger the coagulation cascade by activating factor X in HIV, according to a study published online Aug. 30 in Science Translational Medicine.

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Dietary Approach Effective for Laryngopharyngeal Reflux

FRIDAY, Sept. 8, 2017 (HealthDay News) -- A dietary approach and a traditional treatment approach of proton pump inhibition (PPI) and standard reflux precautions are similarly effective for patients with laryngopharyngeal reflux (LPR), according to a study published online Sept. 7 in JAMA Otolaryngology -- Head & Neck Surgery.

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Vaccine-Type HPV Rates Down for Unvaccinated Young Women

FRIDAY, Sept. 8, 2017 (HealthDay News) -- From 2009-2010 to 2013-2014 there was a decrease in the prevalence of vaccine-type human papillomavirus (HPV) among unvaccinated young women aged 18 to 26 years, according to a study published online Sept. 7 in Obstetrics & Gynecology.

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Statins Tied to Reduced Mortality Risk in COPD

FRIDAY, Sept. 8, 2017 (HealthDay News) -- Statin use is associated with a reduced risk of all-cause and pulmonary-related mortality in patients with chronic obstructive pulmonary disease (COPD), according to a study published online Sept. 7 in Chest.

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Budget Cuts Threaten Research on Antimicrobial Resistance

THURSDAY, Sept. 7, 2017 (HealthDay News) -- Proposed budget cuts could seriously hamper efforts to address antimicrobial resistance (AMR), according to an article published online Sept. 4 in the Annals of Internal Medicine.

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Clinical Oral Food Challenges Result in Few Reactions

THURSDAY, Sept. 7, 2017 (HealthDay News) -- Open, nonresearch low-risk oral food challenges (OFCs) result in few allergic reactions, according to a study published online Sept. 7 in the Annals of Allergy, Asthma & Immunology.

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Tiotropium Effective in Mild to Moderate COPD

THURSDAY, Sept. 7, 2017 (HealthDay News) -- Tiotropium appears to be effective at improving lung function in patients with mild to moderate chronic obstructive pulmonary disease (COPD), according to a study published online Sept. 6 in the New England Journal of Medicine.

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Reduced Asthma Exacerbations Seen With Tezepelumab

THURSDAY, Sept. 7, 2017 (HealthDay News) -- For patients with uncontrolled asthma despite treatment with long-acting beta-agonists and medium-to-high doses of inhaled glucocorticoids, tezepelumab is associated with a significant reduction in asthma exacerbations, according to a study published online Sept. 6 in the New England Journal of Medicine.

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Alendronate Effective, Safe in 'Oldest Old' With Prior Fracture

THURSDAY, Sept. 7, 2017 (HealthDay News) -- Alendronate treatment reduces the risk of hip fracture in elderly patients with a prior fracture, with sustained safety, according to a study published online Aug. 30 in the Journal of Internal Medicine.

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Increase in Medical Exemptions From Immunization in California

WEDNESDAY, Sept. 6, 2017 (HealthDay News) -- There was an increase in the number of children with medical exemptions (MEs) from immunization in California from 2015 to 2016 after elimination of personal belief exemptions (PBEs), according to a research letter published online Sept. 5 in the Journal of the American Medical Association.

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Racial Variation in Antibiotic Prescribing for Viral ARTI

TUESDAY, Sept. 5, 2017 (HealthDay News) -- Non-Hispanic black and Hispanic children are less likely than non-Hispanic white children to receive antibiotics for viral acute respiratory tract infection (ARTI) in the pediatric emergency department (PED), according to a study published online Sept. 5 in Pediatrics.

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PrEP Adherence Decreases Over Time in Adolescent MSM

TUESDAY, Sept. 5, 2017 (HealthDay News) -- For adolescent men who have sex with men (MSM) participating in a 48-week HIV pre-exposure prophylaxis (PrEP) intervention, adherence decreases with quarterly visits, according to a study published online Sept. 5 in JAMA Pediatrics.

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Editorial

More Research Needed for Vitamin D's Cardiac Effect in PCI

TUESDAY, Sept. 5, 2017 (HealthDay News) -- More research is needed to assess the role of vitamin D in the prevention of periprocedural myocardial injury, according to a study published online Aug. 25 in the Journal of Clinical Pharmacology.

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CYP2C9 Variants Linked to Clinical Events in VTE

TUESDAY, Sept. 5, 2017 (HealthDay News) -- For elderly patients treated with vitamin K antagonists for venous thromboembolism (VTE), CYP2C9 variants are associated with any clinical event, according to a study published online Aug. 22 in the Journal of Thrombosis and Haemostasis.

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Dupilumab Improves Quality of Life in Atopic Dermatitis

TUESDAY, Sept. 5, 2017 (HealthDay News) -- For adults with atopic dermatitis (AD), dupilumab improves health-related quality-of-life (HRQoL), and is associated with improved clinical outcomes, according to a study published online Aug. 27 in the British Journal of Dermatology.

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Goshuyuto, Rabeprazole Shown to Treat Refractory H. pylori

TUESDAY, Sept. 5, 2017 (HealthDay News) -- Refractory Helicobacter pylori (HP) infection can be successfully treated with goshuyuto and rabeprazole, according to a case report published online Aug. 28 in the Journal of Digestive Diseases.

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Cognitive Test Predicts Elderly Insulin Injection Success

TUESDAY, Sept. 5, 2017 (HealthDay News) -- A cognitive test involving animal name recall can predict which elderly patients succeed in mastering an insulin self-injection technique within one week, according to a study published online Aug. 28 in the Journal of Diabetes Investigation.

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CBT, SSRIs Effectively Cut Anxiety Symptoms in Childhood

TUESDAY, Sept. 5, 2017 (HealthDay News) -- Cognitive behavioral therapy (CBT) and selective serotonin reuptake inhibitors (SSRIs) are effective for reducing symptoms of anxiety in childhood, according to a review published online Aug. 31 in JAMA Pediatrics.

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Editorial

Benefit of Aspirin After A-Fib Ablation Questioned

FRIDAY, Sept. 1, 2017 (HealthDay News) -- For atrial fibrillation (AF) ablation patients undergoing their index ablation, long-term aspirin therapy is associated with increased rates of bleeding and may not lower risk of stroke, according to a study published online Aug. 28 in the Journal of Cardiovascular Electrophysiology.

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Child Flu Vaccination Down When Nasal Spray Unavailable

FRIDAY, Sept. 1, 2017 (HealthDay News) -- Seasonal flu immunization rates among children appear to have dropped slightly after the U.S. Centers for Disease Control and Prevention recommended against the nasal spray version of the vaccine, according to a study published online recently in Vaccine.

Press Release

CDC: Fentanyl Driving Rise in Opioid-Linked Deaths in U.S.

FRIDAY, Sept. 1, 2017 (HealthDay News) -- Fentanyl is a key player in America's continuing epidemic of opioid-related overdose deaths, according to two reports published in the Sept. 1 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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β-2 Adrenergic Agonists May Help Fight Parkinson's Disease

FRIDAY, Sept. 1, 2017 (HealthDay News) -- β-2 adrenergic agonists might be able to combat Parkinson's disease, according to a study published in the Sept. 1 issue of Science.

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Suicide Risk Up in Younger Patients With Chronic Illness

FRIDAY, Sept. 1, 2017 (HealthDay News) -- Young adults with chronic diseases like asthma and diabetes are more than four times as likely to attempt suicide as their healthy peers, according to a study published online Aug. 17 in the Canadian Journal of Psychiatry.

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Liraglutide Tied to Reduced Progression of Diabetic Kidney Dz

FRIDAY, Sept. 1, 2017 (HealthDay News) -- For patients with type 2 diabetes and high cardiovascular risk receiving usual care, the addition of liraglutide is associated with lower rates of development and progression of diabetic kidney disease, according to a study published in the Aug. 31 issue of the New England Journal of Medicine.

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Electronic Alert Doesn't Up Appropriate Thromboprophylaxis

FRIDAY, Sept. 1, 2017 (HealthDay News) -- A computer-based alert system with a Geneva Risk Score calculation tool in the electronic patient chart does not improve appropriate thromboprophylaxis in patients admitted to general medical wards, according to a study published online Aug. 24 in the Journal of Thrombosis and Haemostasis.

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