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MONTHLY BRIEFINGS - Oct 2017


September 2017 Briefing - Hematology & Oncology

Mon, Oct 2, 2017

Here are what the editors at HealthDay consider to be the most important developments in Hematology & Oncology for September 2017. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Upper Abdominal Cancer Resections Up in Octogenarians

FRIDAY, Sept. 29, 2017 (HealthDay News) -- Rates of major upper abdominal cancer resections in octogenarians are increasing, according to a study published online Sept. 7 in Cancer.

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Embezzlement Widespread in Medical Practices

FRIDAY, Sept. 29, 2017 (HealthDay News) -- Embezzlement is widespread among medical practices, and knowing the warning signs is helpful for preventing it, according to an article published in Medical Economics.

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Accurate Lung Cancer Staging Depends on Quality Nodal Exam

FRIDAY, Sept. 29, 2017 (HealthDay News) -- The prognostic value of pathologic nodal (pN) stratification depends on the thoroughness of nodal examination in the staging of non-small-cell lung cancer, according to a study published online Sept. 28 in JAMA Oncology.

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Checkpoint Inhibitors No Less Safe With Radiation

FRIDAY, Sept. 29, 2017 (HealthDay News) -- Immune-related adverse events (IRAEs), including pneumonitis, are not more common in patients with metastatic lung cancer who receive both immune checkpoint inhibitors (CPIs) and thoracic radiotherapy (TRT), according to a research letter published online Sept. 28 in JAMA Oncology.

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Immune Checkpoint Inhibitor Endocrine Dysfunction Explored

THURSDAY, Sept. 28, 2017 (HealthDay News) -- Patients receiving immune checkpoint inhibitor (ICI) regimens may experience endocrine dysfunction, with increased risk of thyroid dysfunction and hypophysitis for patients on combination therapy, according to a review published online Sept. 28 in JAMA Oncology.

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Propranolol Use Inversely Linked to Melanoma Recurrence

THURSDAY, Sept. 28, 2017 (HealthDay News) -- For patients with melanoma, use of propranolol is associated with reduced risk of recurrence, according to a study published online Sept. 28 in JAMA Oncology.

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More Than 78 Percent of Health Care Personnel Receive Flu Shot

THURSDAY, Sept. 28, 2017 (HealthDay News) -- More than 78 percent of health care personnel (HCP) and 53.6 percent of pregnant women received influenza vaccination during the 2016-2017 influenza season, according to two studies published in the Sept. 29 issue of Morbidity and Mortality Weekly Report.

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Central Neck Dissection Underused in Some Thyroid CA

THURSDAY, Sept. 28, 2017 (HealthDay News) -- Only about one-third of patients with medullary thyroid carcinoma (MTC) undergo initial central neck dissection, which is associated with a reduced rate of reoperation, according to a study published online Sept. 27 in JAMA Surgery.

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Hereditary Hemochromatosis Patients Can Safely Donate Blood

WEDNESDAY, Sept. 27, 2017 (HealthDay News) -- There is no evidence to support excluding patients with hereditary hemochromatosis (HH) from serving as blood donors, according to a review published online Sept. 13 in Hepatology.

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Working With a Scribe Improves Physician Satisfaction

WEDNESDAY, Sept. 27, 2017 (HealthDay News) -- Working with a scribe significantly improves physicians' overall satisfaction, satisfaction with chart quality and accuracy, and charting efficiency, according to a study published online Sept. 11 in the Annals of Family Medicine.

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Cancer Risk Up for RA Patients With Venous Thromboembolism

WEDNESDAY, Sept. 27, 2017 (HealthDay News) -- Patients with rheumatoid arthritis (RA) and venous thromboembolism (VTE) have increased risk of cancer in the first year after VTE and during a longer follow-up period, according to a study published online Sept. 15 in the Journal of Thrombosis and Haemostasis.

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Adjuvant Chemo Beneficial in Advanced Gastroesophageal CA

TUESDAY, Sept. 26, 2017 (HealthDay News) -- Adjuvant chemotherapy is associated with improved survival for patients with locally-advanced gastroesophageal adenocarcinoma treated with preoperative chemoradiotherapy and resection, according to a study published online Sept. 21 in JAMA Oncology.

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CDC Launches Campaign to Fight Prescription Opioid Epidemic

TUESDAY, Sept. 26, 2017 (HealthDay News) -- The U.S. Centers for Disease Control and Prevention is launching a communication campaign featuring accounts of people recovering from opioid use disorder, and those who have lost someone to opioid overdose, in an effort to fight the prescription overdose epidemic.

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Worker Contribution to Health Benefits Up in 2017

MONDAY, Sept. 25, 2017 (HealthDay News) -- In 2017, health benefits coverage remained stable, while workers faced considerable variation in costs, according to a report published online Sept. 19 in Health Affairs.

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Tibetan Yoga Improves Sleep Quality During Chemo

MONDAY, Sept. 25, 2017 (HealthDay News) -- Participation in a Tibetan yoga program (TYP) during chemotherapy results in modest, short-term benefits in sleep quality, with long-term benefits seen over time for those who practice at least two times a week, according to a study published online Sept. 20 in Cancer.

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Childhood-Onset IBD May Raise Risk of Cancer

THURSDAY, Sept. 21, 2017 (HealthDay News) -- Children with inflammatory bowel disease (IBD) face an increased risk of cancer that persists into adulthood, and is especially elevated for gastrointestinal cancers, according to a study published online Sept. 20 in The BMJ.

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High Rate of Anemia Seen After Weight-Loss Surgery

THURSDAY, Sept. 21, 2017 (HealthDay News) -- For many obese Americans, weight-loss surgery may lead to anemia, according to a research letter published online Sept. 20 in JAMA Surgery.

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Insurer Market Power Lowers Providers' Prices

WEDNESDAY, Sept. 20, 2017 (HealthDay News) -- Insurers have the bargaining power to reduce provider prices in highly concentrated provider markets, according to a report published in the September issue of Health Affairs.

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General, Central Obesity Linked to Specific Breast Cancer Risk

WEDNESDAY, Sept. 20, 2017 (HealthDay News) -- General and central obesity are associated with breast cancer risk, with different effects on specific subtypes, according to a study published online Sept. 14 in The Oncologist.

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Naloxegol Has No Effect on Opioid Dose in Opioid-Tied Constipation

WEDNESDAY, Sept. 20, 2017 (HealthDay News) -- For patients with noncancer pain and opioid-induced constipation (OIC), naloxegol has no clinically relevant effect on patient-reported pain levels or mean daily opioid dose, according to research published online Sept. 12 in PAIN Practice.

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Histamine May Play Role in Colorectal Tumorigenesis

WEDNESDAY, Sept. 20, 2017 (HealthDay News) -- Administration of histamine-producing gut microbes to histidine decarboxylase (HDC)-deficient mice reduces inflammation and tumor formation, suggesting an innovative approach to colorectal cancer (CRC) prevention and treatment, according to an experimental study published online Sept. 13 in The American Journal of Pathology.

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ACP Does Not Support Legalization of Assisted Suicide

TUESDAY, Sept. 19, 2017 (HealthDay News) -- The American College of Physicians (ACP) does not support the legalization of physician-assisted suicide, a practice that raises ethical, clinical, and other concerns, according to a position paper published online Sept. 19 in the Annals of Internal Medicine.

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Monthly Feedback Linked to Improved Colonoscopy Quality

TUESDAY, Sept. 19, 2017 (HealthDay News) -- Monthly feedback significantly improves colonoscopy quality measures, but quarterly feedback does not, according to a study published online Sept. 11 in Gastroenterology and Hepatology.

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Extended Thromboprophylaxis Safe, Effective After Liver Surgery

TUESDAY, Sept. 19, 2017 (HealthDay News) -- For patients undergoing liver surgery, extended pharmacologic thromboprophylaxis appears effective and safe, according to a study published online Aug. 28 in the Journal of Thrombosis and Haemostasis.

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PD-L1 Mainly Expressed in Metastatic CRC Lesions

MONDAY, Sept. 18, 2017 (HealthDay News) -- Programmed death-ligand 1 (PD-L1) is primarily expressed in metastatic colorectal cancer (CRC) lesions, according to a study published online Aug. 29 in the Journal of Digestive Diseases.

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Expected Burden of Lung Cancer High for People Living With HIV

MONDAY, Sept. 18, 2017 (HealthDay News) -- For people living with HIV (PLWH), the expected burden of lung cancer is high, if smoking habits do not change, according to a study published online Sept. 18 in JAMA Internal Medicine.

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New Link Seen Between Gene Fusion and Bladder Cancer

MONDAY, Sept. 18, 2017 (HealthDay News) -- The fibroblast growth factor receptor 3 (FGFR3) transforming acidic coiled-coil containing protein 3 (TACC3) (FT3) gene fusion recruits endogenous TACC3 away from the mitotic spindle, resulting in errors in chromosome segregation in bladder cancer cells, according to a study published online Aug. 30 in Open Biology.

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Skin Cancer Prevention Strategies Needed in Work Settings

FRIDAY, Sept. 15, 2017 (HealthDay News) -- Solar occupational ultraviolet (UV) exposure is a major determinant of incident squamous cell carcinoma (SCC), according to a study published online Aug. 27 in the British Journal of Dermatology.

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Physicians Tweeting About Drugs May Have Conflict of Interest

FRIDAY, Sept. 15, 2017 (HealthDay News) -- Most physicians on Twitter with a financial conflict of interest (FCOI) and frequent tweets mention specific drugs for which they have a conflict, according to a study published in the September issue of The Lancet Haematology.

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FDA Approves Aliqopa for Follicular Lymphoma

FRIDAY, Sept. 15, 2017 (HealthDay News) -- Aliqopa (copanlisib) has been approved by the U.S. Food and Drug Administration to treat adults with relapsed follicular lymphoma who have received at least two prior treatments with certain other drugs.

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EHR Data May Beat Claims Data in Assessing Sepsis Incidence

FRIDAY, Sept. 15, 2017 (HealthDay News) -- Sepsis is present in 6 percent of adult hospitalizations, with no change in incidence from 2009 to 2014 based on electronic health record (EHR) data in contrast to claims-based analyses, according to a study published online Sept. 13 in the Journal of the American Medical Association.

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Doctors Spend Almost Six Hours Per Day on EHR Tasks

FRIDAY, Sept. 15, 2017 (HealthDay News) -- Physicians spend almost six hours per day in the electronic health record (EHR), with 4.5 hours spent during clinic hours and 1.4 hours spent after clinic hours, according to a study published in the September/October issue of the Annals of Family Medicine.

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'Science Spin' Found Prevalent in Biomedical Literature

FRIDAY, Sept. 15, 2017 (HealthDay News) -- Spin in biomedical literature (also referred to as "science hype") is prevalent, with trials having the highest and greatest variability in the prevalence of spin, according to a review published online Sept. 11 in PLOS Biology.

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FDA Approves First Biosimilar Drug for Cancer

THURSDAY, Sept. 14, 2017 (HealthDay News) -- The first biosimilar drug to treat cancer has been approved by the U.S. Food and Drug Administration.

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Mutational Signatures Can More Accurately ID MMR Deficiency

THURSDAY, Sept. 14, 2017 (HealthDay News) -- Mutational signatures could more accurately identify mismatch repair (MMR)-deficiency than sequencing of MMR genes, according to a study published online Sept. 13 in Cancer Research.

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Fibrous Dysplasia Associated With Increased Breast Cancer Risk

THURSDAY, Sept. 14, 2017 (HealthDay News) -- Patients with fibrous dysplasia (FD) are at increased risk for breast cancer, according to a study published online Aug. 30 in the Journal of Bone and Mineral Research.

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Some Aspects of Empathy Improve During Medical Training

WEDNESDAY, Sept. 13, 2017 (HealthDay News) -- Certain aspects of empathy improve during medical student training, according to a study published online Sept. 7 in Medical Education.

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AACR Releases 2017 Cancer Progress Report

WEDNESDAY, Sept. 13, 2017 (HealthDay News) -- The age-adjusted U.S. cancer death rate decreased 25 percent from 1991 to 2014, which translates into 2.1 million fewer cancer deaths, according to an annual progress report published by the American Association for Cancer Research.

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Multivitamin Use May Cut Risk of Chemo-Induced Neuropathy

WEDNESDAY, Sept. 13, 2017 (HealthDay News) -- Multivitamin use before diagnosis of breast cancer is associated with reduced risk of symptoms of chemotherapy-induced peripheral neuropathy, according to a study published online Sept. 1 in the Journal of the National Cancer Institute.

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USPSTF Backs Cervical Cancer Screening With Cytology or hrHPV

WEDNESDAY, Sept. 13, 2017 (HealthDay News) -- The U.S. Preventive Services Task Force (USPSTF) recommends cervical cancer screening with cervical cytology alone every three years or screening with high-risk human papillomavirus (hrHPV) testing alone every five years in women ages 30 to 65 years. These findings form the basis of a draft recommendation statement published online Sept. 12 by the USPSTF.

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Good Survival for HSCT-Treated Thalassemia Patients

WEDNESDAY, Sept. 13, 2017 (HealthDay News) -- Patients with thalassemia treated with hematopoietic stem cell transplantation (HSCT) have 30-year survival that is similar to that of conventionally treated (CT) patients, according to a study published online Aug. 29 in the American Journal of Hematology.

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β-Adrenergic Receptor Signaling Affects Tumor Microenvironment

WEDNESDAY, Sept. 13, 2017 (HealthDay News) -- β2-adrenergic receptor (β-AR) signaling in host immune cells regulates CD8+ T-cell frequency and functional orientation within the tumor microenvironment, according to a study published online Aug. 17 in Cancer Research.

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Sentinel Lymph Node Dissection Non-Inferior to Axillary Node

WEDNESDAY, Sept. 13, 2017 (HealthDay News) -- Ten-year overall survival for primary breast cancer patients treated with sentinel lymph node dissection (SLND) alone is similar to that seen in those treated with axillary lymph node dissection (ALND), according to a study published in the Sept. 12 issue of the Journal of the American Medical Association.

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Are Physicians Obligated to Help on Planes?

TUESDAY, Sept. 12, 2017 (HealthDay News) -- Does being a physician carry a moral obligation to respond to calls for medical assistance on airplanes? That is the topic of an article published in the Sept. 12 issue of the Journal of the American Medical Association.

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Antibiotic Rx Adherence Varies Widely in Sickle Cell Care

TUESDAY, Sept. 12, 2017 (HealthDay News) -- Adherence to antibiotic guidelines for acute chest syndrome (ACS) in children with sickle cell disease (SCD) varies widely, according to a study published online Sept. 11 in JAMA Pediatrics.

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Most Opioid Use Concentrated in Top 10 Percent of Users

TUESDAY, Sept. 12, 2017 (HealthDay News) -- The top 10 percent of privately insured U.S. adults without cancer using opioids account for most opioid use, according to a research letter published online Sept. 12 in the Annals of Internal Medicine.

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Median Cost of Cancer Drug Development $648.0 Million

MONDAY, Sept. 11, 2017 (HealthDay News) -- The median cost of cancer drug development is $648.0 million, and revenue after approval is substantial, according to a study published online Sept. 11 in JAMA Internal Medicine.

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Diverse Neurological Effects Linked to Anti-PD-1 Therapy

MONDAY, Sept. 11, 2017 (HealthDay News) -- Neurological complications associated with anti-programmed death 1 (PD-1) antibody treatment have a diverse phenotype, according to a study published online Sept. 5 in JAMA Neurology.

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Zika Virus Preferentially Targets Glioblastoma Stem Cells

MONDAY, Sept. 11, 2017 (HealthDay News) -- Zika virus (ZIKV) is an oncolytic virus that preferentially targets glioblastoma stem cells (GSCs), according to a study published online Sept. 5 in The Journal of Experimental Medicine.

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Vaccine-Type HPV Rates Down for Unvaccinated Young Women

FRIDAY, Sept. 8, 2017 (HealthDay News) -- From 2009-2010 to 2013-2014 there was a decrease in the prevalence of vaccine-type human papillomavirus (HPV) among unvaccinated young women aged 18 to 26 years, according to a study published online Sept. 7 in Obstetrics & Gynecology.

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No Difference in Toxicity for 6-, 2-Fraction HDR in Prostate Cancer

THURSDAY, Sept. 7, 2017 (HealthDay News) -- For men with prostate cancer there is no difference in acute genitourinary or sexual dysfunction between 6- and 2-fraction high-dose-rate (HDR) brachytherapy monotherapy, according to a study published online Aug. 29 in the Journal of Medical Imaging and Radiation Oncology.

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Strong Evidence for Healthy Lifestyle Reducing CRC Risk

THURSDAY, Sept. 7, 2017 (HealthDay News) -- There is strong evidence that physical activity and a healthy diet reduce the risk of colorectal cancer, according to a report published online Sept. 7 by the American Institute for Cancer Research and the World Cancer Research Fund.

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New Referral Pathway Cuts Palliative Radiotherapy Wait

WEDNESDAY, Sept. 6, 2017 (HealthDay News) -- Use of an advanced practice radiation therapist (APRT) may help reduce radiotherapy waiting times for palliative patients, according to a study published Aug. 29 in the Journal of Medical Radiation Sciences.

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Immunosuppressant Response Predicts Aplastic Anemia Survival

WEDNESDAY, Sept. 6, 2017 (HealthDay News) -- Response to immunosuppressive therapy (IST) predicts overall survival (OS) in aplastic anemia (AA), according to a study published online Aug. 29 in the American Journal of Hematology.

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Docs Should Be Aware of Family Beliefs Regarding Nondisclosure

WEDNESDAY, Sept. 6, 2017 (HealthDay News) -- Physicians should be aware of societal codes of conduct that affect family beliefs and behaviors regarding information disclosure to pediatric patients, according to a study published online Sept. 5 in JAMA Pediatrics.

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Mailed Invitations Increase CRC Screening Completion

WEDNESDAY, Sept. 6, 2017 (HealthDay News) -- Mailed outreach invitations offering a fecal immunochemical test (FIT) or colonoscopy increase the proportion of participants completing colorectal cancer (CRC) screening, and providing specific reminders to general practitioners (GPs) improves participation in FIT screening, according to two studies published online Sept. 5 in the Journal of the American Medical Association.

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Universal Sequencing of Cancer Genes Ups Mutation Detection

WEDNESDAY, Sept. 6, 2017 (HealthDay News) -- Universal sequencing of a broad panel of cancer-related genes is associated with increased detection of potentially clinically significant heritable mutations, according to a study published online Sept. 5 in the Journal of the American Medical Association.

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Re-Analysis Shows Screening Reduces Prostate CA Mortality

TUESDAY, Sept. 5, 2017 (HealthDay News) -- Re-analysis of evidence suggests that screening does reduce prostate cancer mortality, according to a study published online Sept. 4 in the Annals of Internal Medicine.

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CYP2C9 Variants Linked to Clinical Events in VTE

TUESDAY, Sept. 5, 2017 (HealthDay News) -- For elderly patients treated with vitamin K antagonists for venous thromboembolism (VTE), CYP2C9 variants are associated with any clinical event, according to a study published online Aug. 22 in the Journal of Thrombosis and Haemostasis.

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Suicide Risk Up in Younger Patients With Chronic Illness

FRIDAY, Sept. 1, 2017 (HealthDay News) -- Young adults with chronic diseases like asthma and diabetes are more than four times as likely to attempt suicide as their healthy peers, according to a study published online Aug. 17 in the Canadian Journal of Psychiatry.

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Low Tumor Growth Rates During Active Surveillance of Thyroid CA

FRIDAY, Sept. 1, 2017 (HealthDay News) -- Among patients with low-risk papillary thyroid cancer (PTC), the rates of tumor growth during active surveillance are low, according to a study published online Aug. 31 in JAMA Otolaryngology-Head & Neck Surgery.

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Crosstalk Identified Between Adipose Tissue, Carcinomas

FRIDAY, Sept. 1, 2017 (HealthDay News) -- There is organ-dependent crosstalk between adipose tissue and carcinomas in various organs, according to a review published in the September issue of Cancer Prevention Research.

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Electronic Alert Doesn't Up Appropriate Thromboprophylaxis

FRIDAY, Sept. 1, 2017 (HealthDay News) -- A computer-based alert system with a Geneva Risk Score calculation tool in the electronic patient chart does not improve appropriate thromboprophylaxis in patients admitted to general medical wards, according to a study published online Aug. 24 in the Journal of Thrombosis and Haemostasis.

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