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January 2018 Briefing - Pathology

Thu, Feb 1, 2018

Here are what the editors at HealthDay consider to be the most important developments in Pathology for January 2018. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

History of Childhood Kidney Disease Linked to Risk of ESRD

WEDNESDAY, Jan. 31, 2018 (HealthDay News) -- A history of childhood kidney disease is associated with increased risk for end-stage renal disease (ESRD) in adulthood, according to a study published in the Feb. 1 issue of the New England Journal of Medicine.

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In Situ Vaccine Uses Immune Response to Treat Cancer

WEDNESDAY, Jan. 31, 2018 (HealthDay News) -- In situ vaccination is an approach that can trigger an immune response in a manner that is specific to the tumor antigens to treat malignancy, according to a study published online Jan. 31 in Science Translational Medicine.

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Survival Trends for Cancer Generally Increasing Worldwide

WEDNESDAY, Jan. 31, 2018 (HealthDay News) -- Worldwide, survival trends for cancer are generally increasing, although there is considerable global variation in survival rates, according to a study published online Jan. 30 in The Lancet.

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TBI Linked to Increased Dementia Risk Over Several Years

WEDNESDAY, Jan. 31, 2018 (HealthDay News) -- Traumatic brain injury (TBI) is associated with persistently increased risk of dementia, according to a study published online Jan. 30 in PLOS Medicine.

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Early Alzheimer's Tied to Rest-Activity Rhythm Fragmentation

TUESDAY, Jan. 30, 2018 (HealthDay News) -- Preclinical Alzheimer's disease (AD) and aging are independently associated with rest-activity rhythm fragmentation among cognitively normal adults, according to a study published online Jan. 29 in JAMA Neurology.

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Mediterranean Diet Adherence Linked to Better IVF Performance

TUESDAY, Jan. 30, 2018 (HealthDay News) -- For non-obese women undergoing in vitro fertilization (IVF), adherence to the Mediterranean diet (MedDiet) is associated with increased likelihood of achieving clinical pregnancy and live birth, according to a study published online Jan. 30 in Human Reproduction.

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E-Cigarette Smoke Carcinogenic to Murine Lung, Bladder

MONDAY, Jan. 29, 2018 (HealthDay News) -- Electronic cigarette (e-cigarette) smoke causes damage to DNA and reduces repair activity in a mouse model and in human cells, according to a study published online Jan. 29 in the Proceedings of the National Academy of Sciences.

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Case Report: Fentanyl Use Associated With Amnesia

MONDAY, Jan. 29, 2018 (HealthDay News) -- Another case of unusual amnestic syndrome that includes bilateral hippocampal lesions on magnetic resonance imaging has been described in a case report published online Jan. 30 in the Annals of Internal Medicine.

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Mortality, CVD, T2DM Risks Not Up for Living Kidney Donors

MONDAY, Jan. 29, 2018 (HealthDay News) -- Living kidney donors have no increased risks for all-cause mortality, cardiovascular disease, hypertension, type 2 diabetes, or adverse psychological health outcomes, according to a review published online Jan. 30 in the Annals of Internal Medicine.

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Regulators Trying to Reduce Physician Burden Linked to EHR

MONDAY, Jan. 29, 2018 (HealthDay News) -- The Office of the National Coordinator for Health Information Technology (ONC) is trying to address some of the issues relating to physician electronic health record (EHR) burden, partly with the appointment of Don Rucker, M.D., who is skilled in informatics and board-certified in emergency and internal medicine, according to an article published in Medical Economics.

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Pre-Op Physical Therapy May Cut Pulmonary Complications

MONDAY, Jan. 29, 2018 (HealthDay News) -- A 30-minute preoperative physical therapy session focused on breathing exercises is associated with a reduced incidence of postoperative pulmonary complications (PPCs) among patients undergoing upper abdominal surgery, according to a study published online Jan. 24 in The BMJ.

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Specific White Matter Patterns Linked to Youth Psychopathology

MONDAY, Jan. 29, 2018 (HealthDay News) -- General psychopathology is a heritable trait in youth that may be detected early in life through brain structural connectivity, according to a study published online Jan. 24 in JAMA Psychiatry.

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Health Care Spending Up, Mainly Due to Rising Prices

MONDAY, Jan. 29, 2018 (HealthDay News) -- Americans under age 65 years who were insured through their employer spent more than ever before on health care in 2016, with faster spending growth in 2016 than in recent years, according to the Health Care Cost Institute (HCCI)'s annual Health Care Cost and Utilization Report.

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2016 Saw Increase in Birth Defects Potentially Linked to Zika

MONDAY, Jan. 29, 2018 (HealthDay News) -- From the first half of 2016 to the second half of 2016, there was an increase in the number of birth defects potentially related to Zika virus infection, according to research published in the Jan. 26 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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Diabetes Impacts Mortality in Breast Cancer Patients

FRIDAY, Jan. 26, 2018 (HealthDay News) -- Breast cancer-specific mortality remains higher among women with diabetes who have longer diabetes duration or preexisting cardiovascular disease, according to a study published online Jan. 19 in Diabetes Care.

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CDC: Many U.S. Adults Have Never Been Tested for HIV

THURSDAY, Jan. 25, 2018 (HealthDay News) -- Almost 40 percent of women and more than 50 percent of men aged 15 to 44 years had never been tested for HIV between 2011 and 2015, according to a report published Jan. 25 by the U.S. Centers for Disease Control and Prevention's National Center for Health Statistics.

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Heart Disease, Stroke Risk Up Even Smoking 1 Cigarette/Day

THURSDAY, Jan. 25, 2018 (HealthDay News) -- Smoking one cigarette per day is still associated with a significant increased risk of coronary heart disease and stroke, according to research published online Jan. 24 in The BMJ.

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Multidomain Lifestyle Intervention May Aid Cognition in APOE ε4 Carriers

THURSDAY, Jan. 25, 2018 (HealthDay News) -- A multidomain lifestyle intervention seems to be beneficial for cognition in older at-risk individuals, even among apolipoprotein E (APOE) ε4 carriers, according to a study published online Jan. 22 in JAMA Neurology.

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Lung Cancer Screening More Efficient for Those at Higher Risk

THURSDAY, Jan. 25, 2018 (HealthDay News) -- Lung cancer screening (LCS) is more effective and efficient for high-risk individuals, according to a research letter published online Jan. 22 in JAMA Internal Medicine.

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Cloning by Somatic Cell Nuclear Transfer Feasible in Monkeys

WEDNESDAY, Jan. 24, 2018 (HealthDay News) -- Cloning cynomolgus monkeys (Macaca fascicularis) is feasible by somatic cell nuclear transfer (SCNT) using fetal fibroblasts, according to a study published online Jan. 24 in Cell.

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Influenza, Some Viral URIs Increase Risk of Acute MI

WEDNESDAY, Jan. 24, 2018 (HealthDay News) -- Certain respiratory infections, especially influenza, are associated with an increased risk of acute myocardial infarction during the first seven days after respiratory specimen collection, according to a study published in the Jan. 25 issue of the New England Journal of Medicine.

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Hyperandrogenism May Affect Gut Microbiome in PCOS

WEDNESDAY, Jan. 24, 2018 (HealthDay News) -- Hyperandrogenism may play a role in changing the gut microbiome in women with polycystic ovary syndrome (PCOS), according to a study published online Jan. 23 in the Journal of Clinical Endocrinology & Metabolism.

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CV Risks, Breast CA Recurrence Down With Exercise in Survivors

WEDNESDAY, Jan. 24, 2018 (HealthDay News) -- Supervised aerobic and resistance exercise may improve metabolic syndrome, sarcopenic obesity, and serum biomarkers in overweight and obese survivors of breast cancer, according to a study published online Jan. 22 in the Journal of Clinical Oncology.

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Next-Generation Sequencing May Be Useful in Joint Infection

WEDNESDAY, Jan. 24, 2018 (HealthDay News) -- Next-generation sequencing may be useful for identifying causative organisms in culture-negative periprosthetic joint infection, according to a study published online Jan. 17 in The Journal of Bone & Joint Surgery.

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Periodontitis in Older Adults Tied to Higher Total Cancer Risk

TUESDAY, Jan. 23, 2018 (HealthDay News) -- Individuals with periodontitis have an increased total cancer risk, according to a study published online Jan. 12 in the Journal of the National Cancer Institute.

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Diabetes Tied to Higher Rates of Serious Infection

TUESDAY, Jan. 23, 2018 (HealthDay News) -- Patients with diabetes, particularly type 1 diabetes mellitus (T1DM), are at increased risk of serious infection, according to a study published online Jan. 12 in Diabetes Care.

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Closed-Head Injury May Induce TBI Even If No Concussive Sx

TUESDAY, Jan. 23, 2018 (HealthDay News) -- Closed-head impact injuries can induce pathologic traumatic brain injury, independent of concussive signs, according to a study published online Jan. 18 in Brain.

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Anti-Thyroid Rx Exposure Ups Risk of Congenital Malformations

TUESDAY, Jan. 23, 2018 (HealthDay News) -- Exposure to anti-thyroid drugs (ATDs) during the first trimester of pregnancy is associated with increased risk of congenital malformations, according to a study published online Jan. 23 in the Annals of Internal Medicine.

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Swallowable Device Can Test for DNA Markers of Barrett's

TUESDAY, Jan. 23, 2018 (HealthDay News) -- A swallowable balloon device has been developed to obtain samples from the lower esophagus -- samples which then undergo assay of combined CCNA1 and VIM DNA methylation to detect Barrett's esophagus metaplasia, according to a study published online Jan. 17 in Science Translational Medicine.

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Drinking in Early Adulthood Tied to Later Risk for Liver Disease

TUESDAY, Jan. 23, 2018 (HealthDay News) -- Alcohol consumption in young men is associated with an increased risk of severe liver disease later in life, according to a study published online Jan. 22 in the Journal of Hepatology.

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Out-of-Pocket Expenditures Down With ACA Implementation

TUESDAY, Jan. 23, 2018 (HealthDay News) -- Implementation of the Affordable Care Act (ACA) was associated with reduced out-of-pocket spending, although increases were noted in mean premium spending, according to a study published online Jan. 22 in JAMA Internal Medicine.

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Older Adults Less Likely to Have Provider-Ordered Flu Testing

MONDAY, Jan. 22, 2018 (HealthDay News) -- Older adults are less likely than younger adults to have provider-ordered influenza testing, according to a study published online Jan. 17 in the Journal of the American Geriatrics Society.

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Nutrients in Child's First 1,000 Days Key for Neurodevelopment

MONDAY, Jan. 22, 2018 (HealthDay News) -- The provision of adequate nutrients and healthy eating during a child's first 1,000 days is important for optimal neurodevelopment, according to an American Academy of Pediatrics policy statement published online Jan. 22 in Pediatrics.

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Urinalysis Is Effective for UTIs in Younger Febrile Infants

FRIDAY, Jan. 19, 2018 (HealthDay News) -- For febrile infants age 60 days and younger, urinalysis is highly sensitive and specific for diagnosing urinary tract infections (UTIs), according to a study published online Jan. 16 in Pediatrics.

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Breast Cancer Genetic Test Less Cost-Effective in Actual Practice

FRIDAY, Jan. 19, 2018 (HealthDay News) -- A gene expression profile test to predict risk of breast cancer recurrence is less cost-effective in real-world practice as compared to ideal conditions, according to a study published online Jan. 8 in the Journal of Clinical Oncology.

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LDL-C Still High in Autosomal Recessive Hypercholesterolemia

FRIDAY, Jan. 19, 2018 (HealthDay News) -- For patients with autosomal recessive hypercholesterolemia (ARH), low-density lipoprotein cholesterol (LDL-C) levels remain high despite intensive treatment, according to a study published in the Jan. 23 issue of the Journal of the American College of Cardiology.

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Blood Test Found to Detect Eight Common Cancer Types

FRIDAY, Jan. 19, 2018 (HealthDay News) -- A multi-analyte blood test, CancerSEEK, can detect eight common cancer types, with high sensitivity and specificity, according to a study published online Jan. 18 in Science.

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Alcohol Induced DNA Repair Genes Prognostic in Gastric Cancer

THURSDAY, Jan. 18, 2018 (HealthDay News) -- For patients with gastric cancer (GC), myeloperoxidase (MPO), transcription factor IIB-related factor 1 (BRF1), and breast cancer susceptibility genes 1 and 2 (BRCA1/2) induced by alcohol have prognostic value, according to a study published in the February issue of The American Journal of Pathology.

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Proinflammatory Diet Linked to Increased Colorectal Cancer Risk

THURSDAY, Jan. 18, 2018 (HealthDay News) -- Proinflammatory diets are associated with increased colorectal cancer risk for men and women, according to a study published online Jan. 18 in JAMA Oncology.

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Increased Risk of Complications With Bariatric Surgery

THURSDAY, Jan. 18, 2018 (HealthDay News) -- Bariatric surgery is associated with lower risks of obesity-related comorbidities but a clinically important increased risk for complications compared with medical treatment, according to a study published in the Jan. 16 issue of the Journal of the American Medical Association, a theme issue on obesity.

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Professionals Disagree About Asking Patients About Sexuality

THURSDAY, Jan. 18, 2018 (HealthDay News) -- National Health Service (NHS) England recently recommended that professionals ask all patients their sexual orientation at every opportunity, although opinions are divided on whether this is appropriate, according to an article published online Jan. 17 in The BMJ.

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Mediterranean Diet May Lower Risk of Aggressive Prostate CA

THURSDAY, Jan. 18, 2018 (HealthDay News) -- High adherence to the Mediterranean diet is associated with a lower risk of aggressive prostate cancer, according to a study published in the February issue of The Journal of Urology.

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Adding HIPEC to Cytoreductive Surgery Beneficial in Ovarian CA

WEDNESDAY, Jan. 17, 2018 (HealthDay News) -- The addition of hyperthermic intraperitoneal chemotherapy (HIPEC) to interval cytoreductive surgery is associated with improved outcomes in patients with stage III epithelial ovarian cancer, according to a study published in the Jan. 18 issue of the New England Journal of Medicine.

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Noninvasive Marker Tied to Diabetic Retinopathy Severity

WEDNESDAY, Jan. 17, 2018 (HealthDay News) -- Disorganization of the inner retinal layers (DRIL) is associated with morphological changes in the outer retina and worse levels of diabetic retinopathy in eyes with diabetic macular edema (DME), according to a study published online Jan. 11 in JAMA Ophthalmology.

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Alzheimer's Disease Variants Linked to Brain Amyloidosis

WEDNESDAY, Jan. 17, 2018 (HealthDay News) -- Certain Alzheimer's disease (AD) risk variants are associated with brain amyloidosis, according to a study published online Jan. 16 in JAMA Neurology.

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Human Rhinovirus Commonly Detected in Febrile Infants

WEDNESDAY, Jan. 17, 2018 (HealthDay News) -- For febrile infants, human rhinovirus (HRV) is common, and detection does not alter risk of concomitant urinary tract infection or invasive bacterial infection, according to a study published online Jan. 17 in Pediatrics.

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High Response of Desmoplastic Melanomas to PD-1 Blockade

WEDNESDAY, Jan. 17, 2018 (HealthDay News) -- Patients with desmoplastic melanoma have a high level of objective tumor response to treatment with antibodies to block programmed cell death 1 (PD-1) or PD-1 ligand (PD-L1), according to a study published online Jan. 10 in Nature.

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Brain Is Susceptible to Acute MI, Chronic Heart Failure

WEDNESDAY, Jan. 17, 2018 (HealthDay News) -- Acute myocardial infarction (MI) and chronic heart failure have effects on the brain, according to a study published in the Jan. 23 issue of the Journal of the American College of Cardiology.

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Psoriasis Remission Described After Hepatitis C Virus Treatment

WEDNESDAY, Jan. 17, 2018 (HealthDay News) -- A case of remission of psoriasis after treatment of chronic hepatitis C virus (HCV) has been described in a research letter published online Jan. 16 in the Annals of Internal Medicine.

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Speech Outcomes Can Be Predicted After Cochlear Implant

WEDNESDAY, Jan. 17, 2018 (HealthDay News) -- Brain areas unaffected by auditory deprivation can predict speech outcomes after cochlear implant (CI) in children, according to a study published online Jan. 15 in the Proceedings of the National Academy of Sciences of the United States of America.

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Lactation Duration Linked to Reduced Incidence of Diabetes

TUESDAY, Jan. 16, 2018 (HealthDay News) -- Lactation duration is associated with reduced incidence of diabetes, according to a study published online Jan. 16 in JAMA Internal Medicine.

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Rising BMI Has Slowed Improvement in U.S. Mortality

TUESDAY, Jan. 16, 2018 (HealthDay News) -- The rate of improvement in mortality in the United States has been slowed by rising body mass index (BMI), according to a study published online Jan. 15 in the Proceedings of the National Academy of Sciences.

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Increased Risk of Thrombosis in Myeloproliferative Neoplasms

TUESDAY, Jan. 16, 2018 (HealthDay News) -- Patients with myeloproliferative neoplasms (MPNs) have increased risk of arterial thrombosis and venous thrombosis across all age groups and MPN subtypes, according to a study published online Jan. 16 in the Annals of Internal Medicine.

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Higher CVD Risk With Early Menarche, Menopause

TUESDAY, Jan. 16, 2018 (HealthDay News) -- Reproductive factors, including early menarche and menopause, are associated with increased cardiovascular disease (CVD) risk, according to a study published online Jan. 15 in Heart.

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BRCA1 Promoter Methylation Tied to High-Grade Serous Ovarian CA

TUESDAY, Jan. 16, 2018 (HealthDay News) -- Elevation in white blood cell BRCA1 promoter methylation is associated with high-grade serous ovarian cancer (HGSOC), according to a study published online Jan. 16 in the Annals of Internal Medicine.

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Non-Ventilator Hospital-Acquired Pneumonia Risk Affects All Ages

FRIDAY, Jan. 12, 2018 (HealthDay News) -- Non-ventilator hospital-acquired pneumonia (NV-HAP) is a significant burden in U.S. acute care hospitals and poses a risk to nonelderly, non-intensive unit (ICU) patients, according to research published in the January issue of the American Journal of Infection Control.

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Worry About Deportation May Increase CV Risk Factors

FRIDAY, Jan. 12, 2018 (HealthDay News) -- Worry about deportation is significantly tied to higher levels of known cardiovascular risk factors, according to a study published online Jan. 8 in the Annals of Behavioral Medicine.

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BRCA May Not Impact Survival in Young-Onset Breast Cancer

FRIDAY, Jan. 12, 2018 (HealthDay News) -- Survival appears to be similar for patients with young-onset breast cancer who carry a BRCA mutation and noncarriers, according to a study published online Jan. 11 in The Lancet Oncology.

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Corynebacterium, Kingella Abundance Tied to HNSCC Risk

FRIDAY, Jan. 12, 2018 (HealthDay News) -- The overall oral microbiome composition is not associated with the risk of head and neck squamous cell carcinoma (HNSCC), but greater abundance of genera Corynebacterium and Kingella is associated with decreased HNSCC risk, according to a study published online Jan. 11 in JAMA Oncology.

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Duration of Diabetes, Prediabetes Linked to Presence of CAC

FRIDAY, Jan. 12, 2018 (HealthDay News) -- Diabetes and prediabetes duration are both independently associated with the presence of coronary artery calcified plaque (CAC) and left ventricular dysfunction, according to a study published online Jan. 9 in Diabetes Care.

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Progress in Fighting Antibiotic Resistance Shown in CDC Map

THURSDAY, Jan. 11, 2018 (HealthDay News) -- The U.S. Centers for Disease Control and Prevention has released new data in its Antibiotic Resistance Investment Map, which shows states' progress in combating antibiotic resistance.

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Hazard Score Can Estimate Age of Prostate Cancer Diagnosis

THURSDAY, Jan. 11, 2018 (HealthDay News) -- A hazard score calculated from 54 single nucleotide polymorphisms can predict age at diagnosis of aggressive prostate cancer (PCa), according to a study published online Jan. 10 in The BMJ.

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AMA Online Tools Address Systems-Level Physician Burnout

THURSDAY, Jan. 11, 2018 (HealthDay News) -- Tools and resources have been developed to help address physician burnout at the systems level, which may affect more than half of doctors, according to a report published by the American Medical Association (AMA).

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Prenatal PPI, H2 Blocker Use Linked to Asthma Risk in Child

THURSDAY, Jan. 11, 2018 (HealthDay News) -- Prenatal, maternal, acid-suppressive drug use is associated with an increased risk of childhood asthma, according to a review published online Jan. 11 in Pediatrics.

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Hepatic Fat Accumulation May Have Causal Role in Liver Disease

THURSDAY, Jan. 11, 2018 (HealthDay News) -- Hepatic fat accumulation may play a causal role in chronic liver disease, according to a study published online Dec. 27 in the Journal of Internal Medicine.

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Acetaminophen Use in Pregnancy Linked to Language Delay

THURSDAY, Jan. 11, 2018 (HealthDay News) -- Acetaminophen (acetyl-para-aminophenol [APAP]) use in pregnancy is associated with language delay among girls, according to a study published online Jan. 10 in European Psychiatry.

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Adherence to Healthy Diet May Cut Effects of Genetics on Obesity

THURSDAY, Jan. 11, 2018 (HealthDay News) -- Improving adherence to healthy dietary patterns may help reduce the genetic association with weight gain, according to a study published online Jan. 10 in The BMJ.

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Psoriasis Is Independent Risk Factor for Comorbidity in Children

THURSDAY, Jan. 11, 2018 (HealthDay News) -- Children with psoriasis have an increased risk of comorbidities compared to children without psoriasis, independent of obesity, according to a study published online Jan. 10 in JAMA Dermatology.

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High-Risk Plaque on Coronary CTA Linked to Future MACE

WEDNESDAY, Jan. 10, 2018 (HealthDay News) -- For outpatients with stable chest pain, high-risk plaque found by coronary computed tomographic angiography (CTA) is associated with subsequent major adverse cardiovascular events (MACE), according to a study published online Jan. 10 in JAMA Cardiology.

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Transfer of Frozen Embryos Doesn't Raise Live-Birth Rate

WEDNESDAY, Jan. 10, 2018 (HealthDay News) -- Transfer of frozen embryos does not increase the live-birth rate for ovulatory women with infertility or for women without polycystic ovary syndrome who are undergoing in vitro fertilization (IVF), according to two studies published online Jan. 10 in the New England Journal of Medicine.

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Economic Impact of Physicians Quantified for 2015

WEDNESDAY, Jan. 10, 2018 (HealthDay News) -- Physicians have a large economic impact across the nation, creating an aggregate of $2.3 trillion of economic activity and supporting employment of nearly 12.6 million Americans, according to a report published by the American Medical Association.

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Predictors of Improved CVD Risk Factors After Bariatric Sx ID'd

WEDNESDAY, Jan. 10, 2018 (HealthDay News) -- Increased weight loss, female sex, and younger age predict increased probability of resolution of specific cardiovascular disease risk factors (CVD-RFs) in adolescents undergoing metabolic and bariatric surgery (MBS), according to a study published online Jan. 8 in Pediatrics.

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Vitamin D3 Improves Arterial Stiffness in Dose-Response Way

WEDNESDAY, Jan. 10, 2018 (HealthDay News) -- For overweight African-Americans with vitamin D deficiency, arterial stiffness is improved by vitamin D3 supplementation in a dose-response manner, according to a study published online Dec. 7 in PLOS ONE.

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Black Children at Higher Risk of Death Following Surgery

WEDNESDAY, Jan. 10, 2018 (HealthDay News) -- Race-specific models more accurately predict risk of death after surgery for pediatric patients, according to a study published online Jan. 10 in Pediatrics.

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Screening, Therapy Effect Varies by Breast CA Molecular Subtype

TUESDAY, Jan. 9, 2018 (HealthDay News) -- The contributions of screening and treatment to decreases in breast cancer mortality vary by molecular subtype, according to a study published in the Jan. 9 issue of the Journal of the American Medical Association.

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USPSTF Questions Adolescent Idiopathic Scoliosis Screening

TUESDAY, Jan. 9, 2018 (HealthDay News) -- The U.S. Preventive Services Task Force (USPSTF) has concluded that the current evidence is insufficient to assess the balance of benefits and harms of screening for adolescent idiopathic scoliosis in children and adolescents aged 10 to 18 years. The recommendation statement has been published in the Jan. 9 issue of the Journal of the American Medical Association.

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Evidence Review
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Long-Term Night Shift Work Linked to Cancer Risk in Women

TUESDAY, Jan. 9, 2018 (HealthDay News) -- There is a positive association between long-term night shift work and the risk of several common cancers for women, with evidence of a dose-response correlation, according to a study published online Jan. 8 in Cancer Epidemiology, Biomarkers & Prevention.

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HIV Screening Most Optimal at 25 Years of Age If No Risk Factors

TUESDAY, Jan. 9, 2018 (HealthDay News) -- For young adults without known risk factors, a one-time routine HIV screen at 25 years would optimize clinical outcomes and be cost-effective, according to a study published in the January issue of the Journal of Adolescent Health.

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Kidney Injury Common After Non-Kidney Transplants in Children

MONDAY, Jan. 8, 2018 (HealthDay News) -- In children who receive a non-kidney solid organ transplant, acute kidney injury (AKI) is common in the first year after surgery and is associated with an increased risk of chronic kidney disease (CKD), according to a study published online Dec. 29 in the American Journal of Transplantation.

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Idiopathic Thrombocytopenic Purpura Tied to Higher CVD Risk

MONDAY, Jan. 8, 2018 (HealthDay News) -- There is an increased risk of developing cardiovascular disease (CVD) among patients with idiopathic thrombocytopenic purpura (ITP), especially those who undergo splenectomy, according to a study published online Jan. 3 in the Journal of Thrombosis and Haemostasis.

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CV Exercise Betters Cardiac Aging in Sedentary Middle-Aged Adults

MONDAY, Jan. 8, 2018 (HealthDay News) -- Two years of high-intensity exercise training (ExT) is associated with improved maximal oxygen uptake and reduced cardiac stiffness in previously sedentary healthy middle-aged adults, according to a study published online Jan. 8 in Circulation.

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Increased Long-Term Mortality for All Weight Categories in T2DM

MONDAY, Jan. 8, 2018 (HealthDay News) -- For patients with type 2 diabetes, all weight categories show increased long-term mortality, with a nadir at a body mass index (BMI) of 25 to <30 kg/m², according to a study published online Jan. 3 in Diabetes Care.

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TP53 Variants Linked to Childhood ALL, Poor Outcomes

MONDAY, Jan. 8, 2018 (HealthDay News) -- TP53 pathogenic variants are overrepresented in children with acute lymphoblastic leukemia (ALL) and are associated with worse outcomes, according to a study published online Jan. 4 in the Journal of Clinical Oncology.

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Maternal Folic Acid, Multivitamin Use May Cut ASD Risk in Offspring

MONDAY, Jan. 8, 2018 (HealthDay News) -- The risk of autism spectrum disorder (ASD) is reduced in offspring with maternal exposure to folic acid and multivitamin supplementation before and during pregnancy, according to a study published online Jan. 3 in JAMA Psychiatry.

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Type 1 IFNs May Mediate Zika Pregnancy Complications

MONDAY, Jan. 8, 2018 (HealthDay News) -- Type 1 interferons (IFNs) may mediate pregnancy complications in the context of congenital Zika virus (ZIKV) infection, according to a study published in the Jan. 5 issue of Science Immunology.

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Repeated Flu Vaccinations Help Prevent Severe Infection

MONDAY, Jan. 8, 2018 (HealthDay News) -- Vaccination for influenza for multiple seasons is twice as effective in preventing severe influenza -- compared with non-severe influenza -- in older patients admitted to hospital, according to a study published in the Jan. 8 issue of CMAJ, the journal of the Canadian Medical Association.

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Physicians Frequently Continue to Work While Ill

FRIDAY, Jan. 5, 2018 (HealthDay News) -- Many physicians continue working and caring for patients while they are sick, according to an article published in Medical Economics.

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Breast Implants Slightly Increase Risk of Breast ALCL

FRIDAY, Jan. 5, 2018 (HealthDay News) -- Breast implants are associated with an increased risk of anaplastic large-cell lymphoma in the breast (breast-ALCL), though the absolute risk is small, according to a study published online Jan. 4 in JAMA Oncology.

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Editorial

For Hospitals, No Benefit for Early Adoption of Financial Incentives

FRIDAY, Jan. 5, 2018 (HealthDay News) -- Hospitals that volunteered to be under financial incentives for more than a decade as part of the Premier Hospital Quality Incentive Demonstration (early adopters) do not have better process scores or lower mortality than hospitals where these incentives were implemented later under the Hospital Value-Based Purchasing program (late adopters), according to a study published online Jan. 4 in The BMJ.

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KRAS Mutations Linked to Brain Arteriovenous Malformations

FRIDAY, Jan. 5, 2018 (HealthDay News) -- Many patients with arteriovenous malformations of the brain have somatic activating KRAS mutations, according to a study published online Jan. 3 in the New England Journal of Medicine.

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Cancer Death Rate Continuing to Decline in United States

FRIDAY, Jan. 5, 2018 (HealthDay News) -- In both men and women in the United States, the cancer death rate declined by about 1.5 percent annually from 2006 to 2015, according to a study published online Jan. 4 in CA: A Cancer Journal for Clinicians.

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CV Morbidity With Hysterectomy Despite Ovarian Conservation

THURSDAY, Jan. 4, 2018 (HealthDay News) -- Hysterectomy with ovarian conservation for benign indications is associated with increased risk of cardiovascular and metabolic conditions, according to a study published online Jan. 3 in Menopause.

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Certain Stresses, Burnout Causing Some Women to Leave Medicine

THURSDAY, Jan. 4, 2018 (HealthDay News) -- Though equal numbers of men and women are now entering medical schools, the majority of physicians are still male, and female physicians face several unique stressors, according to a report published online in Medical Economics.

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Impaired Survival With LVEF <60 Percent in Aortic Stenosis

THURSDAY, Jan. 4, 2018 (HealthDay News) -- For patients with severe aortic stenosis (AS), left ventricular ejection fraction (LVEF) below 60 percent is associated with impaired survival, according to a study published online Dec. 27 in JACC: Cardiovascular Interventions.

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Half of Gastric Cancer Patients Diagnosed From ER Visit

THURSDAY, Jan. 4, 2018 (HealthDay News) -- Half of patients with gastric cancer (GC) are diagnosed as a result of an emergency department visit, which is independently associated with increased mortality, according to a study published recently in the American Journal of Surgery.

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Racial/Ethnic Disparities Up for Live Donor Kidney Transplant

THURSDAY, Jan. 4, 2018 (HealthDay News) -- Racial/ethnic disparities in the receipt of live donor kidney transplantation (LDKT) among first-time kidney transplantation candidates in the United States increased from 1995-1999 to 2010-2014, according to a study published in the Jan. 2 issue of the Journal of the American Medical Association.

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CVD Risk Up With β2-Agonist, Antimuscarinic Antagonist Start

THURSDAY, Jan. 4, 2018 (HealthDay News) -- For patients with chronic obstructive pulmonary disease (COPD), new initiation of inhaled long-acting β2-agonists (LABAs) and long-acting antimuscarinic antagonists (LAMAs) is associated with increased risk of cardiovascular disease (CVD), according to a study published online Jan. 2 in JAMA Internal Medicine.

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Immune-Related Adverse Events Up With Checkpoint Inhibitors

THURSDAY, Jan. 4, 2018 (HealthDay News) -- Although patients with pre-existing autoimmune disease who receive checkpoint inhibitors (CPIs) are at risk for exacerbation of their disease, immune-related adverse events (irAEs), or both, events can often be managed without discontinuing CPIs, according to a review published online Jan. 2 in the Annals of Internal Medicine.

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2013 to 2015 Infant Mortality Rate Varied by State and Race

THURSDAY, Jan. 4, 2018 (HealthDay News) -- The infant mortality rate varied by state, from 4.28 to 9.08 per 1,000 live births in Massachusetts and Mississippi, respectively, in 2013 through 2015, according to a January data brief published by the U.S. Centers for Disease Control and Prevention's National Center for Health Statistics.

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Serum Caffeine, Metabolites May Predict Early Parkinson's Disease

WEDNESDAY, Jan. 3, 2018 (HealthDay News) -- Serum levels of caffeine and its metabolites could be diagnostic biomarkers for early Parkinson's disease (PD), according to a study published online Jan. 3 in Neurology.

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Stem-Cell Transplantation Beneficial for Scleroderma

WEDNESDAY, Jan. 3, 2018 (HealthDay News) -- For patients with scleroderma, myeloablative CD34+ selected autologous hematopoietic stem-cell transplantation is associated with lasting benefits, according to a study published in the Jan. 4 issue of the New England Journal of Medicine.

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Herpes Simplex Infrequently Found in Infant Meningitis Eval

WEDNESDAY, Jan. 3, 2017 (HealthDay News) -- Young infants assessed for central nervous system (CNS) infection rarely have herpes simplex virus (HSV), according to a study published online Jan. 3 in Pediatrics.

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Missed Opportunities to Screen for Lung CA With USPSTF Criteria

WEDNESDAY, Jan. 3, 2018 (HealthDay News) -- Lung cancer screening based on U.S. Preventive Services Task Force (USPSTF) criteria decreased from 2010 to 2015, and risk-targeted screening is associated with modest gains in terms of early lung cancer mortality per person screened, according to two studies published online Jan. 2 in the Annals of Internal Medicine.

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HSPC-Derived CAR T-Cells Capable of Lasting Engraftment

WEDNESDAY, Jan. 3, 2018 (HealthDay News) -- Hematopoietic stem/progenitor cell (HSPC)-derived chimeric antigen receptor (CAR) T-cells are capable of long-term engraftment in a model of HIV/AIDS, according to a study published online Dec. 28 in PLOS Pathogens.

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Silent Myocardial Infarction Linked to Heart Failure Risk

WEDNESDAY, Jan. 3, 2018 (HealthDay News) -- Silent myocardial infarction (SMI) is associated with an increased long-term risk of heart failure, according to a study published in the Jan. 2 issue of the Journal of the American College of Cardiology.

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Higher Risk of Musculoskeletal Disorders in Some Physicians

WEDNESDAY, Jan. 3, 2018 (HealthDay News) -- The prevalence of work-related musculoskeletal disorders (MSDs) appears to be high for at-risk physicians, according to a review published online Dec. 27 in JAMA Surgery.

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Uterine Leiomyomas, Centrifugal Cicatricial Alopecia May Be Linked

WEDNESDAY, Jan. 3, 2018 (HealthDay News) -- Black women with central centrifugal cicatricial alopecia (CCCA) have increased likelihood of uterine leiomyomas (ULs), according to a research letter published online Dec. 27 in JAMA Dermatology.

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10 Percent of Heart Recipients Develop De Novo Malignancy

TUESDAY, Jan. 2, 2018 (HealthDay News) -- More than one in 10 adult heart transplant recipients develop de novo malignancy between one and five years after transplantation, and this is associated with increased mortality, according to a study published in the Jan. 2 issue of the Journal of the American College of Cardiology.

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In Utero Exposure to Topiramate Linked to Risk of Oral Clefts

TUESDAY, Jan. 2, 2018 (HealthDay News) -- Infants born to women exposed to topiramate, especially women with epilepsy taking higher doses, have an increased risk of oral clefts at birth, according to a study published online Dec. 27 in Neurology.

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Prevalence of Autism Seems to Be Stabilizing in U.S. Children, Teens

TUESDAY, Jan. 2, 2018 (HealthDay News) -- The prevalence of autism spectrum disorder (ASD) among U.S. children and adolescents was 2.41 percent in 2014 to 2016, according to a research letter published online Jan. 2 in the Journal of the American Medical Association.

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ACOG Advocates Cascade Testing for Hereditary Gene Mutations

TUESDAY, Jan. 2, 2018 (HealthDay News) -- Obstetrician-gynecologists should be aware of who is eligible for cascade testing, use resources to ensure testing is offered, and know which options can help patients overcome potential barriers to testing, according