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February 2018 Briefing - Pathology

Thu, Mar 1, 2018

Here are what the editors at HealthDay consider to be the most important developments in Pathology for February 2018. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Urinary 8-oxoGsn Promising Biomarker for Physiologic Age

WEDNESDAY, Feb. 28, 2018 (HealthDay News) -- 8-oxo-7, 8-dihydroguanosine (8-oxoGsn) is a promising biomarker for physiologic age, corresponding more closely with age than 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGsn), according to a study published online Feb. 27 in Frontiers in Aging Neuroscience.

Abstract/Full Text

Sleeve Gastrectomy Linked to Improved Glycemia in Mice

WEDNESDAY, Feb. 28, 2018 (HealthDay News) -- Sleeve gastrectomy (SG) is associated with an improvement in glycemia, via increased insulin sensitivity, according to a study published online Feb. 23 in Diabetes.

Abstract/Full Text (subscription or payment may be required)

Many Untreated CIN2 Lesions Regress Spontaneously

WEDNESDAY, Feb. 28, 2018 (HealthDay News) -- Most untreated cervical intraepithelial neoplasia grade 2 (CIN2) lesions regress, especially among women younger than 30 years, according to a review published online Feb. 27 in The BMJ.

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Editorial

New Risk Score Assesses Stroke Risk After MI Without A-Fib

WEDNESDAY, Feb. 28, 2018 (HealthDay News) -- A new risk score incorporates readily accessible risk factors associated with the occurrence of stroke in patients after myocardial infarction (MI) in the absence of atrial fibrillation (AF), according to a study published in the Feb. 20 issue of the Journal of the American College of Cardiology.

Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Early Studies Often Show Exaggerated Treatment Effect

TUESDAY, Feb. 27, 2018 (HealthDay News) -- Trials to evaluate drugs or devices used to treat chronic medical conditions that are published early in the chain of evidence often show an exaggerated treatment effect compared with subsequent trials, according to research published online Feb. 21 in the Mayo Clinical Proceedings.

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Editorial

Women With Non-Obstructive CAD May Suffer From Myocardial Scars

TUESDAY, Feb. 27, 2018 (HealthDay News) -- Among women with suspected ischemia and no obstructive coronary artery disease (INOCA), the prevalence of baseline late gadolinium enhancement (LGE) indicating presence of myocardial scars is 8 percent, according to a research letter published in the Feb. 20 issue of Circulation, a Go Red For Women issue focused on women's heart health.

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Sleeve Gastrectomy Tied to Drop in GDM, Excessive Fetal Growth

TUESDAY, Feb. 27, 2018 (HealthDay News) -- Laparoscopic sleeve gastrectomy is associated with a lower rate of gestational diabetes mellitus and excessive fetal growth, according to a study published online Feb. 5 in Obstetrics & Gynecology.

Abstract/Full Text (subscription or payment may be required)

Lead, Other Toxic Metals Found in E-Cigarette Vapors

MONDAY, Feb. 26, 2018 (HealthDay News) -- Toxic metals, including lead, leak from some Electronic cigarettes (e-cigarettes) heating coils and are present in the aerosols inhaled by users, according to a study published in the February issue of Environmental Health Perspectives.

Abstract/Full Text

Recommendations for Optimizing Hidden Curriculum in Medicine

MONDAY, Feb. 26, 2018 (HealthDay News) -- In a position paper published online Feb. 27 in the Annals of Internal Medicine, the American College of Physicians (ACP) presents recommendations for optimizing clinical learning environments by fostering a positive hidden curriculum in medicine.

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Editorial (subscription or payment may be required)

Factors Tied to Molecular Testing by Dermatopathologists ID'd

MONDAY, Feb. 26, 2018 (HealthDay News) -- Among dermatopathologists, relevant instruction during residency training, primary board certification in pathology, and academic medical center affiliation are among the factors associated with more frequent utilization of molecular testing, according to a study published online Feb. 13 in the Journal of Cutaneous Pathology.

Abstract/Full Text (subscription or payment may be required)

Coronary Artery Dz Extent Similar in Men, Women With T1DM

MONDAY, Feb. 26, 2018 (HealthDay News) -- For patients with type 1 diabetes, the extent of coronary artery disease (CAD) is similar in women and men admitted for coronary angiography, according to a study published online Feb. 20 in Diabetes Care.

Abstract/Full Text (subscription or payment may be required)

MRI Risk Model May Cut Biopsy Use in Suspected Prostate Cancer

MONDAY, Feb. 26, 2018 (HealthDay News) -- A risk model including magnetic resonance imaging (MRI)-derived parameters may reduce the number of unnecessary biopsies among patients with suspected prostate cancer, according to a study published online Feb. 22 in JAMA Oncology.

Abstract/Full Text (subscription or payment may be required)

Artificial Intelligence May Help Prevent Physician Burnout

FRIDAY, Feb. 23, 2018 (HealthDay News) -- Artificial intelligence (AI), in which computers can be trained to recognize patterns in large quantities of data, may be able to reduce physicians' burdens, saving them time and energy, according to a report published in Medical Economics.

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Growth Rates of Small Renal Masses Highly Variable Early On

FRIDAY, Feb. 23, 2018 (HealthDay News) -- Among patients who opt for active surveillance of small renal masses, growth rates are highly variable early on and do not reliably predict adverse outcomes, according to a study published in the March issue of The Journal of Urology.

Abstract/Full Text

Menopausal Hormone Therapy Tied to Less Pronounced Kyphosis

FRIDAY, Feb. 23, 2018 (HealthDay News) -- Menopausal hormone therapy (HT) use is associated with less pronounced kyphosis compared with never-use, according to a study published online Feb. 16 in Menopause.

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Dermoscopic Criteria Identified for Diagnosing Melanoma in Situ

FRIDAY, Feb. 23, 2018 (HealthDay News) -- The most frequent dermoscopic criteria for melanoma in situ (MIS) are regression, atypical network, and irregular dots and/or globules, according to a study published online Feb. 21 in JAMA Dermatology.

Abstract/Full Text
Editorial (subscription or payment may be required)

Younger Onset of T2DM Linked to Increased Mortality Risk

FRIDAY, Feb. 23, 2018 (HealthDay News) -- Younger onset of type 2 diabetes is associated with increased mortality risk, mainly due to cardiovascular disease (CVD) mortality, according to a study published online Feb. 22 in Diabetologia.

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GI Surgical Site Infections Higher in Low-Income Countries

WEDNESDAY, Feb. 14, 2018 (HealthDay News) -- The burden of surgical site infection (SSI) after gastrointestinal surgery is greater for countries with low income as classified by the U.N. Human Development Index (HDI), according to a study published online Feb. 13 in The Lancet Infectious Diseases.

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Gut Microbiota May Affect Vertical Transmission of Being Overweight

THURSDAY, Feb. 22, 2018 (HealthDay News) -- The correlation between maternal pre-pregnancy overweight and childhood overweight at ages 1 and 3 years may be mediated by birth mode and infant gut microbiota, according to a study published online Feb. 19 in JAMA Pediatrics.

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Editorial (subscription or payment may be required)

CDC: No Change in Percentage of Uninsured in U.S. From '16 to '17

THURSDAY, Feb. 22, 2018 (HealthDay News) -- The percentage of uninsured U.S. persons of all ages did not change significantly from 2016 to the first nine months of 2017, according to a report published online Feb. 22 by the National Center for Health Statistics.

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Regardless of CV Risks, Cancer History Impacts Mortality

THURSDAY, Feb. 22, 2018 (HealthDay News) -- Cancer history has an important impact on mortality independent of cardiovascular risk factors (CVRFs), according to a study published online Feb. 12 in the Journal of Thrombosis and Haemostasis.

Abstract
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Odds of ARDS Up After Cardiac Surgery During Flu Season

WEDNESDAY, Feb. 21, 2018 (HealthDay News) -- Undergoing cardiac surgery during the influenza season is associated with increased likelihood of development of acute respiratory distress syndrome (ARDS), according to a research letter published in the Feb. 21 issue of the New England Journal of Medicine.

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In A-Fib Patients, Stroke Risk Higher for Blacks Than Whites

WEDNESDAY, Feb. 21, 2018 (HealthDay News) -- Compared with whites, blacks are at increased risk of developing an ischemic stroke either before or after diagnosis of atrial fibrillation (AF), according to a study published online Feb. 20 in Heart Rhythm.

Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Obesity Linked to Improved Survival in Metastatic Melanoma

WEDNESDAY, Feb. 21, 2018 (HealthDay News) -- For men with metastatic melanoma treated with targeted or immune therapy, obesity is associated with improved survival, according to a study published online Feb. 13 in The Lancet Oncology.

Abstract
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Mental Stress-Induced Myocardial Ischemia Risk Up for Women

WEDNESDAY, Feb. 21, 2018 (HealthDay News) -- Compared with men, women have an increased risk of mental stress-induced myocardial ischemia (MSIMI) after myocardial infarction (MI), with microvascular dysfunction and peripheral vasoconstriction with mental stress implicated in MSIMI in women, according to a study published in the Feb. 20 issue of Circulation, a Go Red For Women issue focused on women's heart health.

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Burnout Found Prevalent Among Doctors in Single Health System

TUESDAY, Feb. 20, 2018 (HealthDay News) -- Burnout is prevalent among physicians, affecting over one-third of physicians in a single health system, and is associated with health care delivery, according to a research letter published online Feb. 19 in JAMA Internal Medicine.

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Mortality Risks of Exclusive Cigar, Cigarette, Pipe Use ID'd

TUESDAY, Feb. 20, 2018 (HealthDay News) -- Exclusive current cigarette and cigar use is associated with increased risk of all-cause mortality, according to a study published online Feb. 19 in JAMA Internal Medicine.

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Prognostic Signatures Compared for ER-Positive Breast Cancer

TUESDAY, Feb. 20, 2018 (HealthDay News) -- For women with node-negative early endocrine receptor (ER)-positive breast cancer, the PAM50-based Prosigna risk of recurrence (ROR), Breast Cancer Index (BCI), and EndoPredict (EPclin) provide the most prognostic information, according to a study published online Feb. 15 in JAMA Oncology.

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Molecular Markers May ID Alzheimer's Before Clinical Onset

FRIDAY, Feb. 16, 2018 (HealthDay News) -- For young adults with autosomal dominant Alzheimer's disease (AD), molecular markers can identify changes associated with the disease before clinical onset, according to a study published online Feb. 12 in JAMA Neurology.

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Anti-Heroin Vaccine Shows Promise Against Lethal Doses

FRIDAY, Feb. 16, 2018 (HealthDay News) -- A toll-like receptor 9 (TLR9) agonist in the presence of alum is stable over a month and elicits strong anti-heroin antibody titers and blockade of heroin-induced antinociception, according to a study published online Feb. 8 in Molecular Pharmaceutics.

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Influenza A(H3N2) Viruses Predominate 2017-2018 Season

FRIDAY, Feb. 16, 2018 (HealthDay News) -- Most influenza viruses identified in the 2017 to 2018 season are influenza A, with A(H3N2) viruses predominating, according to research published in the Feb. 16 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

Abstract/Full Text - Budd
Abstract/Full Text - Flannery

Induced Pluripotent Stem Cell Vaccine Promising for Cancer

THURSDAY, Feb. 15, 2018 (HealthDay News) -- Induced pluripotent stem cell (iPSC) vaccines prevent tumor growth in syngeneic murine cancer models in a prophylactic setting, according to a study published online Feb. 15 in Cell Stem Cell.

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Ultra-Processed Food Linked to Increased Overall Cancer Risk

THURSDAY, Feb. 15, 2018 (HealthDay News) -- Consumption of ultra-processed food is associated with increased risk of overall and breast cancer, according to a study published online Feb. 14 in The BMJ.

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Increased Premature Mortality Risk Seen for Single Fathers

THURSDAY, Feb. 15, 2018 (HealthDay News) -- Single fathers have a significantly higher risk of mortality than single mothers or partnered fathers, according to a study published online Feb. 14 in The Lancet Public Health.

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Laryngovideostroboscopy Useful for Vocal Fold Lesion Screening

THURSDAY, Feb. 15, 2018 (HealthDay News) -- Laryngovideostroboscopy (LVS) is effective for screening each patient with persistent dysphonia for vocal fold lesions, according to a study published online Jan. 10 in Head & Neck.

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Poor Outcomes With Systolic BP Below 120 mm Hg in HFpEF

WEDNESDAY, Feb. 14, 2018 (HealthDay News) -- For hospitalized patients with heart failure with preserved ejection fraction (HFpEF), poor outcomes are seen in association with a systolic blood pressure (SBP) level below 120 mm Hg, according to a study published online Feb. 14 in JAMA Cardiology.

Abstract/Full Text (subscription or payment may be required)

New Model Stratifies Patients With Long Bone Metastases

WEDNESDAY, Feb. 14, 2018 (HealthDay News) -- A model with four categories has been developed to stratify patients with symptomatic long bone metastases (LBM) based on their expected survival, according to an article published online Feb. 7 in the Journal of Bone & Joint Surgery.

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In Alzheimer's, BACE1 Inhibition May Reverse Amyloid Deposition

WEDNESDAY, Feb. 14, 2018 (HealthDay News) -- Sustained and increasing BACE1 inhibition can reverse amyloid deposition in a mouse model of Alzheimer's disease (AD), according to a study published online Feb. 14 in the Journal of Experimental Medicine.

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Low Dose-Rate Far-UVC Light Can Inactivate Influenza Virus

WEDNESDAY, Feb. 14, 2018 (HealthDay News) -- Very low-dose 222-nm UVC ultraviolet light can inactivate more than 95 percent of aerosolized H1N1 influenza virus, according to a study published online Feb. 9 in Scientific Reports.

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Higher Biopsy Rates for Women Undergoing Screening Breast MRI

WEDNESDAY, Feb. 14, 2018 (HealthDay News) -- Women undergoing screening breast magnetic resonance imaging (MRI) have higher biopsy rates and significantly lower cancer yield findings compared with screening mammography alone, regardless of personal history of breast cancer (PHBC), according to a study published online Feb. 12 in JAMA Internal Medicine.

Abstract/Full Text (subscription or payment may be required)

Genetics Should Inform Care in Noncompaction Cardiomyopathy

WEDNESDAY, Feb. 14, 2018 (HealthDay News) -- Genetic stratification should play a role in clinical care of patients with noncompaction cardiomyopathy (NCCM), according to a study published in the Feb. 20 issue of the Journal of the American College of Cardiology.

Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Mean Depth of Ultrasonographic Penetration Greater in Autism

WEDNESDAY, Feb. 14, 2018 (HealthDay News) -- Children with autism spectrum disorder (ASD) have a significantly greater mean depth of ultrasonographic penetration, according to a study published online Feb. 12 in JAMA Pediatrics.

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Lipoproteins, Lipids Have Similar Ties to MI, Ischemic Stroke

TUESDAY, Feb. 13, 2018 (HealthDay News) -- Lipoproteins and lipids are similarly associated with risk of myocardial infarction (MI) and ischemic stroke (IS) but not intracerebral hemorrhage (ICH), according to a study published in the Feb. 13 issue of the Journal of the American College of Cardiology.

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Editorial (subscription or payment may be required)

Perfluoroalkyl Substances Linked to Greater Weight Regain

TUESDAY, Feb. 13, 2018 (HealthDay News) -- Higher concentrations of perfluoroalkyl substances (PFASs) are associated with greater weight regain in a diet-induced weight-loss setting, according to a study published online Feb. 13 in PLOS Medicine.

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Four Best Practices Outlined to Prevent Health Care Cyberattacks

TUESDAY, Feb. 13, 2018 (HealthDay News) -- Four best practices outlined that can help prevent health care cyberattacks, which increased from 2016 to 2017, according to a report published in Managed Healthcare Executive.

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USPSTF Recommends Against Ovarian Cancer Screening

TUESDAY, Feb. 13, 2018 (HealthDay News) -- The U.S. Preventive Services Task Force (USPSTF) recommends against screening for ovarian cancer in asymptomatic women. These findings form the basis of a final recommendation statement published in the Feb. 13 issue of the Journal of the American Medical Association.

Evidence Report
Final Recommendation Statement
Editorial

Losartan May Improve Endothelial Function in Marfan Syndrome

TUESDAY, Feb. 13, 2018 (HealthDay News) -- The therapeutic significance of losartan in Marfan syndrome (MFS) may lie in its ability to activate protective endothelial function, not in its angiotensin II (AngII) receptor type 1 (ATR1) inhibition, according to a study published online Feb. 9 in the American Journal of Pathology.

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Opioid Use Linked to Risk of Invasive Pneumococcal Disease

MONDAY, Feb. 12, 2018 (HealthDay News) -- Opioid use is associated with elevated risk of invasive pneumococcal disease (IPD), especially for long-acting, high-potency, and high-dose opioids, according to a study published online Feb. 13 in the Annals of Internal Medicine.

Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Limited Evidence for Effect of Cranial Electrical Stimulation

MONDAY, Feb. 12, 2018 (HealthDay News) -- Evidence for the effectiveness of cranial electrical stimulation (CES) is sparse, according to a review published online Feb. 13 in the Annals of Internal Medicine.

Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

EHRs Not Sufficient to Ensure Success in Value-Based Care

MONDAY, Feb. 12, 2018 (HealthDay News) -- Electronic health records (EHRs) are not sufficient to ensure success in value-based care, according to an article published in Medical Economics.

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Mortality Up in Diabetes With Low eGFR, No Albuminuria

MONDAY, Feb. 12, 2018 (HealthDay News) -- Among U.S. adults with diabetes, albumin-to-creatinine ratio (ACR) values are decreasing, but mortality rates are increasing among those with ACR <30 mg/g and low estimated glomerular filtration rates (eGFRs), according to a study published online Feb. 7 in Diabetes Care.

Abstract/Full Text (subscription or payment may be required)

Cause of Sudden Unexpected Infant Deaths Shifts in the U.S.

MONDAY, Feb. 12, 2018 (HealthDay News) -- From 1999 to 2015 there was a small reduction in the rate of sudden unexpected infant death (SUID), according to a study published online Feb. 12 in Pediatrics.

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Premature Dementia Risk May Be Up in Survivors of Heart Defects

MONDAY, Feb. 12, 2018 (HealthDay News) -- Congenital heart disease (CHD) is associated with increased risk of dementia in adults, according to a study published online Feb. 12 in Circulation.

Abstract/Full Text (subscription or payment may be required)

Criteria for Prostate Cancer Trials Disproportionately Exclude Blacks

MONDAY, Feb. 12, 2018 (HealthDay News) -- Almost half of clinical trials for prostate cancer use criteria that disproportionately exclude black men, according to a research letter published online Feb. 8 in JAMA Oncology.

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Low Postnatal Levels of Arachidonic Acid Linked to ROP

MONDAY, Feb. 12, 2018 (HealthDay News) -- For infants born at a gestational age (GA) of less than 28 weeks, low postnatal levels of arachidonic acid (AA) are associated with developing retinopathy of prematurity (ROP), according to a study published online Feb. 8 in JAMA Ophthalmology.

Abstract/Full Text
Editorial (subscription or payment may be required)

Ultrasound for Rectal Cancer Staging Tied to More Chemoradiation

MONDAY, Feb. 12, 2018 (HealthDay News) -- Use of endoscopic ultrasound (EUS) for rectal cancer (RC) staging is associated with higher use of neoadjuvant chemoradiation but no significant improvement in overall survival, according to a study published online Jan. 26 in the Journal of Gastroenterology and Hepatology.

Abstract
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Diabetes Signs May Be Present 20 Years Before Diagnosis

FRIDAY, Feb. 9, 2018 (HealthDay News) -- Risk of developing type 2 diabetes (T2D) is associated with subtle elevations of glucose and lipids more than 20 years before diagnosis, according to a study published online Feb. 5 in Diabetes, Obesity and Metabolism.

Abstract
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Prenatal, Early Life Fructose Intake Associated With Asthma

FRIDAY, Feb. 9, 2018 (HealthDay News) -- Maternal prenatal and early childhood intake of sugar-sweetened beverages and fructose is associated with current asthma in midchildhood, regardless of adiposity, according to a study published in the Annals of the American Thoracic Society.

Abstract/Full Text (subscription or payment may be required)

Low Serum Sodium Linked to Cognitive Decline in Older Men

THURSDAY, Feb. 8, 2018 (HealthDay News) -- Low serum sodium is associated with cognitive impairment and cognitive decline among community-dwelling older men, according to a study published online Feb. 8 in the Clinical Journal of the American Society of Nephrology.

Abstract
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Breastfeeding Found to Be Protective Against Hypertension

THURSDAY, Feb. 8, 2018 (HealthDay News) -- Postmenopausal women who breastfed more children, or breastfed for a longer duration, have a lower risk of hypertension, according to a study published online Jan. 30 in the American Journal of Hypertension.

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Poll: Personal Beliefs Shouldn't Allow Doctors to Refuse to Treat

THURSDAY, Feb. 8, 2018 (HealthDay News) -- Most people do not believe that professionals including health care providers should be allowed to refuse to provide services based on their conscience or beliefs, according to a recent HealthDay/The Harris Poll.

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ICD Placement Doesn't Improve Survival in Patients With CKD

THURSDAY, Feb. 8, 2018 (HealthDay News) -- For implantable cardioverter defibrillator (ICD)-eligible patients with chronic kidney disease (CKD), ICD placement does not improve survival, according to a study published online Feb. 5 in JAMA Internal Medicine.

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Positive Age Beliefs May Protect Seniors Against Dementia

THURSDAY, Feb. 8, 2018 (HealthDay News) -- Positive age beliefs may protect against dementia, even among older individuals with APOE ε4, according to a study published online Feb. 7 in PLOS ONE.

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Updated Review Confirms Worse Stroke Outcomes for Women

THURSDAY, Feb. 8, 2018 (HealthDay News) -- Women have more activity limitations and worse health-related quality of life (HRQoL) after stroke, according to a review published online Feb. 8 in Stroke.

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HSV-1 Prevalence 47.8 Percent in 14- to 49-Year-Olds

WEDNESDAY, Feb. 7, 2018 (HealthDay News) -- The prevalence of herpes simplex virus type 1 (HSV-1) and HSV-2 is 47.8 and 11.9 percent, respectively, for individuals aged 14 to 49 years, according to a February data brief published by the U.S. Centers for Disease Control and Prevention's National Center for Health Statistics.

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Stem Cell Transplant May Be Effective for Systemic Sclerosis

WEDNESDAY, Feb. 7, 2018 (HealthDay News) -- Stem cell transplant may be an effective treatment for systemic sclerosis (SSc), according to a small study published online Feb. 2 in the International Journal of Rheumatic Diseases.

Abstract
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HPV Prevalence 4.9 Percent in Tonsil Tissue of Healthy Adults

WEDNESDAY, Feb. 7, 2018 (HealthDay News) -- The prevalence of human papillomavirus (HPV) and of high-risk HPV type 16 or 18 is 4.9 and 3.9 percent, respectively, in the tonsil tissue of healthy adults, according to a study published online Jan. 25 in JAMA Otolaryngology-Head & Neck Surgery.

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High Detection Rates of High-Grade DCIS Persist

WEDNESDAY, Feb. 7, 2018 (HealthDay News) -- High detection rates of high-grade ductal carcinoma in situ (DCIS) persist in consecutive subsequent screening rounds versus the prevalence round, while there are decreases in detection rates of low- and intermediate-grade DCIS, according to a study published in the February issue of Radiology.

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Mutations Common in Pancreatic CA, History of Other Cancers

TUESDAY, Feb. 6, 2018 (HealthDay News) -- A substantial proportion of individuals with pancreatic cancer and a history of other hereditary breast and ovarian cancer (HBOC)- or Lynch syndrome (LS)-related cancers have mutations in a prostate cancer susceptibility gene, according to a study published online Jan. 23 in Cancer.

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USPSTF Recommends Screening for Syphilis in Pregnancy

TUESDAY, Feb. 6, 2018 (HealthDay News) -- The U.S. Preventive Services Task Force (USPSTF) concludes that there is considerable net benefit to screening for syphilis infection in pregnant women. These findings form the basis of a draft recommendation statement, published Feb. 6 by the USPSTF.

Draft Evidence Review
Draft Recommendation Statement
Comment on Recommendation

Possible Link Found Between Poor Diet and Back Injuries

TUESDAY, Feb. 6, 2018 (HealthDay News) -- A high advanced glycation end product (H-AGE) diet is associated with decreased vertebral microstructure, mechanical behaviors, and fracture resistance in young female mice, according to a study published recently in the Journal of Bone and Mineral Research.

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Heart Failure Guideline Adherence May Be Best Quality Measure

TUESDAY, Feb. 6, 2018 (HealthDay News) -- Hospital adherence to heart failure guidelines might be the best quality measure, according to a study published online Jan. 29 in Circulation.

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Hot Tea + Alcohol or Smoking May Up Esophageal Cancer Risk

MONDAY, Feb. 5, 2018 (HealthDay News) -- Consumption of tea at high temperatures in combination with alcohol and tobacco exposure is associated with increased risk of esophageal cancer, according to a study published online Feb. 6 in the Annals of Internal Medicine.

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Editorial (subscription or payment may be required)

Humanities Exposure Positively Impacts Medical Students

MONDAY, Feb. 5, 2018 (HealthDay News) -- Exposure to the humanities correlates with less burnout and higher levels of positive personal qualities among medical students, according to a study published online Jan. 29 in the Journal of General Internal Medicine.

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Zika Virus Infection Linked to Uteroplacental Pathology

MONDAY, Feb. 5, 2018 (HealthDay News) -- Zika virus (ZIKV) infection seems to be associated with uteroplacental pathology and may affect oxygen transport within the placenta in pregnant rhesus macaques, according to a study published online Jan. 17 in Nature Communications.

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Low-Carb Diets May Raise the Risk of Neural Tube Defects

MONDAY, Feb. 5, 2018 (HealthDay News) -- Low-carbohydrate diets may increase the risk of neural tube defects in offspring, according to a study published online Jan. 25 in Birth Defects Research.

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Factors Identified That Impact Physicians IT Adoption

FRIDAY, Feb. 2, 2018 (HealthDay News) -- Physicians have considerable concerns about the efficacy and evidence base of health information technology (IT), according to a report published by the American Medical Association (AMA).

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Chronic Disease Major Risk Factor for Cancer, Cancer Mortality

FRIDAY, Feb. 2, 2018 (HealthDay News) -- Chronic disease is associated with a substantial proportion of the risk of incident cancer and cancer mortality, according to a study published online Jan. 31 in The BMJ.

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Estimated Biopsy Rate Varies After Breast Cancer Treatment

FRIDAY, Feb. 2, 2018 (HealthDay News) -- The estimated biopsy rate after breast cancer treatment varies, according to a study published online Jan. 31 in JAMA Surgery.

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Editorial (subscription or payment may be required)

Ibuprofen May Harm Fetal Ovaries During First Trimester

FRIDAY, Feb. 2, 2018 (HealthDay News) -- Exposure to ibuprofen is harmful to developing human fetal ovaries ex vivo in the first trimester, according to a study published online Feb. 2 in Human Reproduction.

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TTFields Tied to Improved Survival in Glioblastoma Patients

FRIDAY, Feb. 2, 2018 (HealthDay News) -- For patients with glioblastoma, the addition of tumor-treating fields (TTFields) to standard treatment with temozolomide is associated with improved survival without negative effects on health-related quality of life (HRQoL) other than itchy skin, according to a study published online Feb. 1 in JAMA Oncology.

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Parental Type 1 Diabetes May Increase Offspring Risk for ADHD

FRIDAY, Feb. 2, 2018 (HealthDay News) -- Children whose parents have type 1 diabetes (T1D) have a higher risk of being diagnosed with attention-deficit/hyperactivity disorder (ADHD), according to a study published online Jan. 26 in Diabetes Care.

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Medicaid Expansion Cuts Out-of-Pocket Spending

THURSDAY, Feb. 1, 2018 (HealthDay News) -- States that expanded Medicaid cut the probability of non-elderly near-poor adults being uninsured and lowered average out-of-pocket spending, according to a study published online Jan. 24 in Health Affairs.

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AHA: Breast Cancer Patients at Increased Risk for CV Disease

THURSDAY, Feb. 1, 2018 (HealthDay News) -- Due to shared risk factors and impact on heart health from cancer treatment, comprehensive care is necessary for breast cancer patients to optimize both cancer treatment and cardiovascular health, according to a scientific statement from the American Heart Association published online Feb. 1 in Circulation.

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Migraine Linked to Increased Risk of Cardiovascular Disease

THURSDAY, Feb. 1, 2018 (HealthDay News) -- Migraine is associated with elevated risks of myocardial infarction, stroke (ischemic and hemorrhagic), venous thromboembolism, and atrial fibrillation or flutter, according to a study published online Jan. 31 in The BMJ.

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Zika-Related Flaviviruses May Cause Congenital Infection

THURSDAY, Feb. 1, 2018 (HealthDay News) -- Emerging neurotropic flaviviruses related to Zika virus (ZIKV) may share ZIKV's capacity for transplacental transmission, according to a study published online Jan. 31 in Science Translational Medicine.

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Postnatal Depression Tied to Child Behavioral Problems

THURSDAY, Feb. 1, 2018 (HealthDay News) -- Persistent and severe maternal postnatal depression (PND) is associated with increased likelihood of multiple adverse child outcomes, including behavioral disturbance, according to a study published online Jan. 31 in JAMA Psychiatry.

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