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MONTHLY BRIEFINGS - Dec 2017


December 2017 Briefing - Pathology

Tue, Jan 2, 2018

Here are what the editors at HealthDay consider to be the most important developments in Pathology for December 2017. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Atopic Dermatitis Associated With Higher Risk of Skin Cancer

THURSDAY, Dec. 28, 2017 (HealthDay News) -- Atopic dermatitis (AD) is associated with an increased risk of developing squamous cell carcinoma (SCC), according to a study published online Dec. 15 in the International Journal of Dermatology.

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Criteria Developed for Idiopathic Inflammatory Myopathies

THURSDAY, Dec. 28, 2017 (HealthDay News) -- New classification criteria have been developed for idiopathic inflammatory myopathies (IIM), according to an article published in the December issue of Arthritis & Rheumatology.

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Neuroanatomic Abnormalities ID'd in Those at Risk for Autism

THURSDAY, Dec. 28, 2017 (HealthDay News) -- Neuroanatomic abnormalities are seen in cohorts at high risk for autism spectrum disorder (ASD), according to a study published in the January issue of Radiology.

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Three-Quarters Receiving 'End of Life Option Act' Drugs Take Them

THURSDAY, Dec. 28, 2017 (HealthDay News) -- About three-quarters of patients in California who receive End of Life Option Act (EOLOA) drugs ingest them and die, according to a research letter published online Dec. 26 in JAMA Internal Medicine.

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Exposure to PM2.5, Ozone at Low Levels Linked to Mortality

WEDNESDAY, Dec. 27, 2017 (HealthDay News) -- Short-term exposure to ambient fine particulate matter (PM2.5) and warm-season ozone at levels below current national air quality standards is associated with increased risk of mortality in the U.S. Medicare population, according to a study published in the Dec. 26 issue of the Journal of the American Medical Association.

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Weak Association for Blood Lead Levels, Criminal Behavior

WEDNESDAY, Dec. 27, 2017 (HealthDay News) -- Childhood blood lead level (BLL) is a poor discriminator between criminal conviction and no conviction, according to a study published online Dec. 26 in JAMA Pediatrics.

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Risk of ESRD in T1DM Patients Has Fallen Markedly in Finland

WEDNESDAY, Dec. 27, 2017 (HealthDay News) -- The cumulative risk of end-stage renal disease (ESRD) among patients with type 1 diabetes has declined over time in Finland, according to a study published online Dec. 20 in Diabetes Care.

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Reducing Tx May Harm Safety in Early HPV+ Oropharyngeal Cancer

WEDNESDAY, Dec. 27, 2017 (HealthDay News) -- For patients with human papillomavirus (HPV)+ stage I or II oropharyngeal cancer, deintensification of treatment from chemoradiotherapy to one modality may compromise safety, according to a study published online Dec. 15 in Cancer.

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Plasma Volume Changes May Mediate Effects of Empagliflozin

TUESDAY, Dec. 26, 2017 (HealthDay News) -- The reduction in risk of cardiovascular (CV) death with empagliflozin is most mediated by changes in hematocrit and hemoglobin, according to research published online Dec. 4 in Diabetes Care.

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GERD Linked to Upper Aerodigestive Tract Cancers

TUESDAY, Dec. 26, 2017 (HealthDay News) -- Gastroesophageal reflux disease (GERD) is associated with a higher risk of cancer in the upper aerodigestive tract (UADT) among the elderly population in the United States, according to a study published online Dec. 21 in JAMA Otolaryngology-Head & Neck Surgery.

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Normalized Post-Op CEA May Help Predict Colon Cancer Prognosis

TUESDAY, Dec. 26, 2017 (HealthDay News) -- Colon cancer patients with elevated preoperative carcinoembryonic antigen (CEA) levels that normalize after resection are not at increased risk for poor prognosis, according to a study published online Dec. 21 in JAMA Oncology.

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Good Long-Term Survival After Childhood Liver Transplant

TUESDAY, Dec. 26, 2017 (HealthDay News) -- Liver transplantation in childhood is associated with good long-term survival, according to a study published online Dec. 15 in the American Journal of Transplantation.

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Gene Polymorphisms Linked to Risk of Chronic Post-Op Pain

TUESDAY, Dec. 26, 2017 (HealthDay News) -- Genetics may be a factor in the experience of chronic pain post surgery, according to a study published online Dec. 14 in Anesthesiology.

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Early-Stage Cancer Diagnoses Up With ACA's Medicaid Expansions

THURSDAY, Dec. 21, 2017 (HealthDay News) -- In their first year, the 2014 Medicaid expansions, facilitated by the Affordable Care Act, were associated with an increase in cancer diagnoses, particularly at the early stage, according to a study published online Dec. 21 in the American Journal of Public Health.

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Cancer Probability Documentation Lacking for Some at High Risk

THURSDAY, Dec. 21, 2017 (HealthDay News) -- For patients with high-risk indeterminate pulmonary nodes (IPNs), physicians rarely provide quantitative documentation of cancer probability, according to a study published online Dec. 20 in JAMA Surgery.

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CDC: 2015 to 2016 Saw Drop in Life Expectancy in United States

THURSDAY, Dec. 21, 2017 (HealthDay News) -- From 2015 to 2016, life expectancy decreased by one-tenth of a year, and there was an increase in the rate of age-adjusted drug overdose deaths, according to two December data briefs published by the U.S. Centers for Disease Control and Prevention's National Center for Health Statistics.

Abstract/Full Text - Kochanek
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Higher TSH Levels Seen in Women With Unexplained Infertility

WEDNESDAY, Dec. 20, 2017 (HealthDay News) -- Women with unexplained infertility (UI) have higher thyroid-stimulating hormone (TSH) levels than women with a normal fertility evaluation, according to a study published online Dec. 19 in the Journal of Clinical Endocrinology & Metabolism.

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Medicare Costs Associated With Mortality Rates in AMI Patients

WEDNESDAY, Dec. 20, 2017 (HealthDay News) -- For patients hospitalized with acute myocardial infarction, Medicare expenditure growth is associated with reduced 180-day case fatality, according to a study published online Dec. 20 in JAMA Cardiology.

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Herpes Zoster Risk Not Up in Systemically Treated Psoriasis

WEDNESDAY, Dec. 20, 2017 (HealthDay News) -- For patients with psoriasis, the risk of herpes zoster (HZ) is not significantly increased for systemically treated patients or for those receiving biologics versus nonbiologics, according to a research letter published online Dec. 20 in JAMA Dermatology.

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Rheumatic Diseases Associated With Increased Dementia Risk

WEDNESDAY, Dec. 20, 2017 (HealthDay News) -- Patients with various rheumatic diseases have an increased risk of dementia, according to a study published online Dec. 15 in the International Journal of Rheumatic Diseases.

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Levonorgestrel IUD Feasible for Low-Risk, Early Uterine Cancer

WEDNESDAY, Dec. 20, 2017 (HealthDay News) -- A levonorgestrel-releasing intrauterine device (LNG-IUD) is effective in the majority of patients undergoing conservative treatment for low-risk endometrial cancer and complex atypical hyperplasia, according to a case-series study published online Dec. 4 in Obstetrics & Gynecology.

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Switching Dual Antiplatelet Therapy Beneficial After ACS

WEDNESDAY, Dec. 20, 2017 (HealthDay News) -- Switching dual antiplatelet therapy (DAPT) from aspirin plus ticagrelor or prasugrel to aspirin plus clopidogrel after acute coronary syndrome (ACS) provides benefits regardless of initial platelet reactivity, according to a study published in the Dec. 26 issue of JACC: Cardiovascular Interventions.

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DPP-4 Inhibitor Has Dissociated Effects on β-Cell Function

WEDNESDAY, Dec. 20, 2017 (HealthDay News) -- For healthy adults and individuals with well-controlled type 2 diabetes (T2D), a single dose of the dipeptidyl peptidase-4 inhibitor sitagliptin is associated with increased standardized insulin secretion, with no impact on β-cell glucose sensitivity, according to a study published online Dec. 11 in Diabetes, Obesity and Metabolism.

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Tumor-Treating Fields Aid Survival With Glioblastoma

TUESDAY, Dec. 19, 2017 (HealthDay News) -- The use of the tumor-treating fields (TTFields) treatment modality, in addition to maintenance chemotherapy, significantly improves survival in patients with glioblastoma, according to a study published in the Dec. 19 issue of the Journal of the American Medical Association.

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Two Cases of Progressive Cutaneous Anthrax Described

TUESDAY, Dec. 19, 2017 (HealthDay News) -- Two cases of cutaneous anthrax which started on the right forearm and progressed are described in a case report published online Dec. 12 in the International Journal of Dermatology.

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Special Precautions Not Advised for Flu Vaccine in Egg Allergic

TUESDAY, Dec. 19, 2017 (HealthDay News) -- Inactivated influenza vaccine (IIV) and live attenuated influenza vaccine (LAIV) are safe for individuals with egg allergy of any severity, according to a practice parameter update published online Dec. 19 in the Annals of Asthma, Allergy & and Immunology.

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Cancer Therapies May Trigger Aging Phenotypes in Survivors

TUESDAY, Dec. 19, 2017 (HealthDay News) -- Cancer therapies have direct effects on telomere length, epigenetic modifications, and microRNA, which can mimic phenotypes of aging, according to a review published online Dec. 18 in ESMO Open.

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USPSTF Reviews Use of ECG for Preventing A-Fib, CVD Events

TUESDAY, Dec. 19, 2017 (HealthDay News) -- The U.S. Preventive Services Task Force (USPSTF) has found that the current evidence is inadequate to assess the benefits and harms of screening with electrocardiogram (ECG) for atrial fibrillation (AF) in older adults; and for low-risk adults, screening with resting or exercise ECG is not recommended for preventing cardiovascular disease (CVD) events. These findings form the basis of two draft recommendation statements published online Dec. 19 by the USPSTF.

Evidence Review - A-FIB
Draft Recommendation Statement - A-FIB
Comment on Recommendation Statement - A-FIB
Evidence Review - CVD
Draft Recommendation Statement - CVD
Comment on Recommendation Statement - CVD

Primary Care Crucial for Preventing New HIV Infections

TUESDAY, Dec. 19, 2017 (HealthDay News) -- Primary care providers will play an important role in preventing the next wave of HIV infections, according to a report published in Medical Economics.

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Gingko Biloba Extract Found Effective in Acute Ischemic Stroke

TUESDAY, Dec. 19, 2017 (HealthDay News) -- For acute ischemic stroke, Ginkgo biloba extract (GBE) in combination with aspirin alleviates cognitive and neurological deficits, according to a study published online Dec. 18 in Stroke and Vascular Neurology.

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RA Exposure In Utero Tied to Increased Disease Risk

TUESDAY, Dec. 19, 2017 (HealthDay News) -- Children born to mothers with rheumatoid arthritis may have an increased risk of rheumatoid arthritis, thyroid disease, and epilepsy, according to a study published online Dec. 11 in Arthritis Care & Research.

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Equation Predicts Risk of End-Stage Renal Disease in Children

MONDAY, Dec. 18, 2017 (HealthDay News) -- The kidney failure risk equation (KFRE) is a simple tool that provides excellent discrimination of the risk of end-stage renal disease (ESRD) in children with chronic kidney disease (CKD), according to a study published online Dec. 18 in JAMA Pediatrics.

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No Magic Bullet for Preventing Late-Life Dementia

MONDAY, Dec. 18, 2017 (HealthDay News) -- The evidence of benefit for different types of interventions to prevent late-life dementia is limited, according to four reviews published online Dec. 18 in the Annals of Internal Medicine.

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Male U.S. Doctors Receive Higher Values of Industry Payments

MONDAY, Dec. 18, 2017 (HealthDay News) -- Male physicians in the United States received higher values of general payments from industry than females in 2015, according to a research letter published online Dec. 18 in JAMA Internal Medicine.

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Payment for Laboratory Tests Set to Reduce Starting Jan. 1, 2018

MONDAY, Dec. 18, 2017 (HealthDay News) -- The Centers for Medicare & Medicaid Services (CMS) has released the Clinical Laboratory Fee Schedule, which is set to reduce payments for testing services conducted in physician office-based laboratories, according to a report published by the American Medical Association (AMA).

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Long-Term Macrolide Use Linked to Resistant P. Acnes

MONDAY, Dec. 18, 2017 (HealthDay News) -- Long-term oral macrolide administration may increase macrolide-resistant Propionibacterium acnes, according to a study published online Dec. 13 in the Journal of Dermatology.

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High Fatty Liver Index Tied to Colorectal Adenomas

MONDAY, Dec. 18, 2017 (HealthDay News) -- The fatty liver index may be an accurate predictor of colorectal adenomas among an average-risk population, according to a study published in the January issue of Diseases of the Colon & Rectum.

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Anaphylaxis Is Rare Complication of Pregnancy

MONDAY, Dec. 18, 2017 (HealthDay News) -- Anaphylaxis is a rare complication of pregnancy, with an estimated incidence of 1.6 per 100,000 maternities, according to a study published online Nov. 29 in BJOG: An International Journal of Obstetrics and Gynaecology.

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Year One Results Out for Value-Based Payment Modifier Program

MONDAY, Dec. 18, 2017 (HealthDay News) -- Almost 30 percent of eligible practices failed to register and report data in the first year of the Physician Value-Based Payment Modifier program, according to a report published in the December issue of Health Affairs.

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Microbiome Intervention With Niacin Aids Insulin Sensitivity

MONDAY, Dec. 18, 2017 (HealthDay News) -- A targeted microbiome intervention, accomplished through microencapsulated delayed-release niacin, beneficially affects insulin sensitivity in humans, according to a study published online Dec. 6 in Diabetes Care.

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Lab + Companion Tests Perform Similarly for Oncology Analytes

FRIDAY, Dec. 15, 2017 (HealthDay News) -- Laboratory-developed tests (LDTs) and U.S. Food and Drug Administration-approved companion diagnostics (FDA-CDs) have similar, excellent accuracy for diagnosing variants in three oncology-related genes, according to a brief report published online Dec. 14 in JAMA Oncology.

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Doctors Must Report on at Least 1 Patient, 1 Measure for MACRA

FRIDAY, Dec. 15, 2017 (HealthDay News) -- In order to meet the 2017 Medicare and CHIP Reauthorization Act (MACRA) participation reporting deadline and avoid a Medicare payment penalty in 2019, physicians must report on at least one patient and one measure by Dec. 31, and submit to Medicare no later than Feb. 28, 2018, according to a report from the American Medical Association (AMA).

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Ulixertinib Is Active in Patients With Advanced Solid Tumors

FRIDAY, Dec. 15, 2017 (HealthDay News) -- The ERK1/2 kinase inhibitor ulixertinib is active and safe for patients with advanced solid tumors, according to a study published online Dec. 15 in Cancer Discovery.

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H. Pylori Infection Found to Be Related to Gallbladder Diseases

FRIDAY, Dec. 15, 2017 (HealthDay News) -- Gallstones are less common with Helicobacter pylori infection among a Chinese population, according to a study published Nov. 27 in the Journal of Gastroenterology & Hepatology.

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Majority of Women Prefer Non-Invasive Testing for Trisomy 21

FRIDAY, Dec. 15, 2017 (HealthDay News) -- The majority of both high-risk and intermediate-risk women prefer a non-invasive cell-free prenatal DNA screening (NIPT) as a secondary screening test for trisomy 21, according to a study published online Nov. 10 in BJOG: An International Journal of Obstetrics and Gynaecology.

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Multiple Myeloma Survival Down With High ADAR1 RNA Expression

FRIDAY, Dec. 15, 2017 (HealthDay News) -- Amplification of the inflammation-responsive RNA editase adenosine deaminase acting on RNA (ADAR)1 gene is associated with reduced survival in multiple myeloma (MM), according to a study published online Dec. 4 in Nature Communications.

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Functional Limitations Ongoing With Congenital Zika

FRIDAY, Dec. 15, 2017 (HealthDay News) -- Severe functional limitations are reported among children with microcephaly and laboratory evidence of Zika virus infection in infancy, according to research published in the Dec. 15 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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Flu Vaccine Expected to Protect Against Most U.S. H3N2 Viruses

FRIDAY, Dec. 15, 2017 (HealthDay News) -- A novel bioinformatics approach can predict vaccine effectiveness for the influenza season, and indicates that the current vaccines are likely to be effective against H3N2 flu viruses in the U.S. 2017/2018 flu season, according to research published online Nov. 29 in F1000 Research.

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Prevalence of Diabetes Tops 20 Percent Among U.S. Veterans

THURSDAY, Dec. 14, 2017 (HealthDay News) -- The overall prevalence of diabetes among U.S. veterans was 20.5 percent in 2013 to 2014, according to a study published online Dec. 14 in the U.S. Centers for Disease Control and Prevention's Preventing Chronic Disease.

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Making Insurers Participate in Marketplace Could Cut Volatility

THURSDAY, Dec. 14, 2017 (HealthDay News) -- Requiring insurers that participate in Medicare or Medicaid to also participate in Marketplaces in the same geographic area could improve access to insurance, according to a study published in the December issue of Health Affairs.

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Stereotactic Body Radiation Can Cut Ventricular Tachycardia

THURSDAY, Dec. 14, 2017 (HealthDay News) -- Noninvasive mapping of cardiac arrhythmias with electrocardiographic imaging and noninvasive delivery of precise ablative radiation with stereotactic body radiation therapy (SBRT) can reduce the burden of ventricular tachycardia, according to a study published in the Dec. 14 issue of the New England Journal of Medicine.

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Recent Change in Spectrum of HIV-Linked Kidney Disease

THURSDAY, Dec. 14, 2017 (HealthDay News) -- The spectrum of HIV-associated kidney disease has changed with the improvement of therapy for HIV infection, according to a review article published in the Dec. 14 issue of the New England Journal of Medicine.

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Serum Homocysteine Higher in Acne Patients

THURSDAY, Dec. 14, 2017 (HealthDay News) -- Acne patients have higher levels of serum homocysteine (HCY), according to a study published online Nov. 21 in the Journal of Cosmetic Dermatology.

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Day-Care Centers Have More Allergens Than Homes

THURSDAY, Dec. 14, 2017 (HealthDay News) -- Mite, mouse, cat, and dog allergens are higher in day-care centers (DCCs) than in homes, according to a study published online Nov. 29 in Allergy.

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Findings Could Help Reduce Risk of Calciphylaxis in Renal Disease

WEDNESDAY, Dec. 13, 2017 (HealthDay News) -- For patients with late-stage renal disease, the presence of lupus anticoagulant and combined thrombophilias are risk factors for the development of calciphylaxis, according to a study published online Dec. 13 in JAMA Dermatology.

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In Utero Methylphenidate Exposure Tied to Heart Defects

WEDNESDAY, Dec. 13, 2017 (HealthDay News) -- Intrauterine exposure to methylphenidate is associated with a small increase in the risk of cardiac malformations, according to a study published online Dec. 13 in JAMA Psychiatry.

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Serial hsTnT Level IDs Risk of 30-Day Adverse Cardiac Event

WEDNESDAY, Dec. 13, 2017 (HealthDay News) -- High-sensitivity troponin (hsTnT) assay can identify patients presenting with suspected acute coronary syndrome at very low risk for 30-day adverse cardiac events (ACE), according to a study published online Dec. 13 in JAMA Cardiology.

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Disrupted Sleep Linked to Increased Amyloid-β Production

WEDNESDAY, Dec. 13, 2017 (HealthDay News) -- Disrupted sleep is associated with increased amyloid-β production in adults, according to a study published online Dec. 8 in the Annals of Neurology.

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C. Difficile + Kidney Injury Admissions Are Up

WEDNESDAY, Dec. 13, 2017 (HealthDay News) -- Hospital admissions of patients with Clostridium difficile infection (CDI) and accompanying acute kidney injury (AKI) are increasing, according to a study published online Dec. 4 in the Journal of Gastroenterology and Hepatology.

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Atopic Dermatitis Severity Tied to IgG Response to S. Aureus

TUESDAY, Dec. 12, 2017 (HealthDay News) -- Atopic dermatitis (AD) disease severity is associated with immunoglobulin G (IgG) responses against Staphylococcus aureus antigens, according to a study published online Nov. 30 in the British Journal of Dermatology.

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Artificial Intelligence Promising for CA, Retinopathy Diagnoses

TUESDAY, Dec. 12, 2017 (HealthDay News) -- A deep learning algorithm can detect metastases in sections of lymph nodes from women with breast cancer; and a deep learning system (DLS) has high sensitivity and specificity for identifying diabetic retinopathy, according to two studies published online Dec. 12 in the Journal of the American Medical Association.

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Cognitive Status Doesn't Impact Cortical Aβ, Tau in Parkinson's

TUESDAY, Dec. 12, 2017 (HealthDay News) -- Patterns of cortical β-amyloid (Aβ) and tau are not different for patients with Parkinson's disease (PD) who are cognitively normal (PD-CN) or with mild cognitive impairment (MCI) and for healthy adults, according to a study published online Dec. 11 in JAMA Neurology.

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Omalizumab Ups Efficacy of Multifood Oral Immunotherapy

TUESDAY, Dec. 12, 2017 (HealthDay News) -- Omalizumab improves the efficacy of multifood oral immunotherapy among pediatric patients with multifood allergies, according to a study published online Dec. 12 in The Lancet Gastroenterology & Hepatology.

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DNA Sequencing Identifies Alpha-1 Antitrypsin Deficiency

TUESDAY, Dec. 12, 2017 (HealthDay News) -- SERPINA1 DNA sequencing can identify alpha-1 antitrypsin deficiency (AATD), according to research published online Nov. 28 in the Annals of the American Thoracic Society.

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Preconception Paternal SSRI Use Linked to ADHD in Offspring

MONDAY, Dec. 11, 2017 (HealthDay News) -- Paternal use of selective serotonin reuptake inhibitors (SSRIs) before conception is associated with increased risk of attention-deficit/hyperactivity disorder (ADHD) in offspring, according to a study published online Dec. 11 in Pediatrics.

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β-Cell Sensitivity to Glucose Impaired After Gastric Bypass

MONDAY, Dec. 11, 2017 (HealthDay News) -- Individuals with prior Roux-en-Y gastric bypass (GB) have blunted β-cell sensitivity to changes in glycemia, according to a study published online Nov. 20 in Diabetes, Obesity and Metabolism.

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Deceleration in Health Care Spending Growth in 2016

MONDAY, Dec. 11, 2017 (HealthDay News) -- Health care spending growth slowed in 2016 following faster growth in 2014 and 2015, according to research published online Dec. 6 in Health Affairs.

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Prenatal Sugar Intake May Increase Asthma Risk in Offspring

FRIDAY, Dec. 8, 2017 (HealthDay News) -- Increased maternal prenatal and early childhood intake of sugar-sweetened beverages and fructose is associated with increased odds of developing childhood asthma, according to a study published online Dec. 8 in the Annals of the American Thoracic Society.

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Telomere Fusions Predict Dysplasia, Invasive Pancreatic CA

FRIDAY, Dec. 8, 2017 (HealthDay News) -- Telomere fusions predict the presence of high-grade dysplasia (HGD) and/or invasive pancreatic cancer, according to a study published online Dec. 8 in the Journal of Molecular Diagnostics.

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Influenza Picking Up in U.S., Predominantly A(H3N2)

FRIDAY, Dec. 8, 2017 (HealthDay News) -- Influenza activity was low during October 2017 but started increasing in November, with influenza A, predominantly A(H3N2), most commonly identified, according to research published in the Dec. 8 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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Ovarian CA Screening Potentially Cost-Effective in the U.S.

FRIDAY, Dec. 8, 2017 (HealthDay News) -- Multimodal screening (MMS) for ovarian cancer is potentially cost-effective in the United States, according to a study published online Dec. 7 in JAMA Oncology.

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Bariatric Surgery Alters Liver Fatty Acid Metabolism

FRIDAY, Dec. 8, 2017 (HealthDay News) -- Bariatric surgery seems to change fatty acid metabolism in the liver, according to a study published online Nov. 20 in Diabetes Care.

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15 Million Americans Expected to Have Alzheimer's by 2060

THURSDAY, Dec. 7, 2017 (HealthDay News) -- A total of 15.0 million Americans are expected to have clinical Alzheimer's disease (AD) or mild cognitive impairment by 2060, according to a study published online Dec. 7 in Alzheimer's & Dementia.

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Pharmacomechanical Thrombolysis No Benefit in DVT

THURSDAY, Dec. 7, 2017 (HealthDay News) -- The addition of pharmacomechanical thrombolysis does not reduce the risk of post-thrombotic syndrome among patients with acute proximal deep vein thrombosis, according to a study published in the Dec. 7 issue of the New England Journal of Medicine.

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Gene Therapy Shows Beneficial Effect in Men With Hemophilia B

THURSDAY, Dec. 7, 2017 (HealthDay News) -- For men with hemophilia B who have factor IX coagulant activity of 2 percent or less of normal value, infusion of a single-stranded adeno-associated viral (AAV) vector with factor IX Padua transgene is associated with a reduction in annualized bleeding rate, and in factor use, according to a study published in the Dec. 7 issue of the New England Journal of Medicine.

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Breast CA Risk Up With Recent Hormonal Contraceptive Use

THURSDAY, Dec. 7, 2017 (HealthDay News) -- Women who currently use or who have recently used contemporary hormonal contraceptives may have an increased risk of breast cancer, although the absolute increase is small, according to a study published in the Dec. 7 issue of the New England Journal of Medicine.

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Metabolic Risk Factors Linked to Severe Liver Disease

THURSDAY, Dec. 7, 2017 (HealthDay News) -- Metabolic risk factors are associated with severe liver disease, according to a study published online Nov. 22 in Hepatology.

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CRP Levels Potentially Useful in Chronic Spontaneous Urticaria

WEDNESDAY, Dec. 6, 2017 (HealthDay News) -- C-reactive protein (CRP) levels are frequently elevated in patients with chronic spontaneous urticaria (CSU), and these elevations are relevant and potentially useful in management of the condition, according to a study published online Nov. 12 in Allergy.

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Traffic Pollution Prevents Cardiac Benefits of Walking

WEDNESDAY, Dec. 6, 2017 (HealthDay News) -- The beneficial cardiopulmonary effects of walking are attenuated when walking in a traffic polluted area, according to a study published online Dec. 5 in The Lancet.

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State Newborn Screening Policies Cut Infant Cardiac Deaths

TUESDAY, Dec. 5, 2017 (HealthDay News) -- Implementation of state newborn screening policies for critical congenital heart disease is associated with a decrease in infant cardiac deaths, according to a study published in the Dec. 5 issue of the Journal of the American Medical Association.

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Acute Intermittent Porphyria Described in Teen Girl

TUESDAY, Dec. 5, 2017 (HealthDay News) -- A case of a 16-year-old presenting to the emergency department with acute intermittent porphyria (AIP) is described in a case report published online Dec. 5 in Pediatrics.

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Diagnostic Mutations ID'd in Chronic Kidney Disease Patients

TUESDAY, Dec. 5, 2017 (HealthDay News) -- About one-quarter of adults with chronic kidney disease (CKD) of unknown cause or familial nephropathy or hypertension have diagnostic mutations, which can be identified with whole-exome sequencing (WES), according to a study published online Dec. 5 in the Annals of Internal Medicine.

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Lipid-Linked Genetic Risk Tied to Abdominal Aortic Aneurysm

TUESDAY, Dec. 5, 2017 (HealthDay News) -- Lipid-associated genetic risk correlates with the risk of abdominal aortic aneurysm (AAA), according to a study published online Nov. 29 in JAMA Cardiology.

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Lymph Node Density Predicts Thyroid Cancer Outcomes

TUESDAY, Dec. 5, 2017 (HealthDay News) -- Lymph node density (LND) can help predict outcomes in patients with papillary thyroid cancer, according to a study published online Nov. 30 in JAMA Otolaryngology -- Head & Neck Surgery .

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Link Between Diabetes, Antibiotic Use Called Into Question

TUESDAY, Dec. 5, 2017 (HealthDay News) -- Previous findings that systemic use of antibiotics increases the risk of diabetes may actually be explained by clinical and lifestyle factors, according to a study published online Nov. 20 in Diabetes, Obesity and Metabolism.

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CVS-Aetna Merger Has Implications for Doctors' Offices

TUESDAY, Dec. 5, 2017 (HealthDay News) -- CVS Health's planned purchase of insurance giant Aetna, a $69 billion deal, was announced Sunday.

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Spatial Variation in Psychosis Incidence in Rural Areas

MONDAY, Dec. 4, 2017 (HealthDay News) -- In rural areas, there is spatial variation in the incidence of nonaffective and affective psychotic disorders, according to a study published online Nov. 29 in JAMA Psychiatry.

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Ceruloplasmin ID'd As Marker of Kidney Disease in Sickle Cell

MONDAY, Dec. 4, 2017 (HealthDay News) -- In patients with sickle cell anemia (SCA), urinary ceruloplasmin (CP) may complement urinary free hemoglobin as a noninvasive biomarker for chronic kidney disease (CKD), according to research published online Nov. 27 in the American Journal of Hematology.

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Nivolumab May Induce Successful Depletion of HIV Reservoir

MONDAY, Dec. 4, 2017 (HealthDay News) -- Nivolumab treatment for non-small-cell lung cancer may induce successful depletion of HIV reservoir, according to a letter to the editor published online Dec. 1 in the Annals of Oncology.

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Oral Microbiome Composition Linked to Esophageal Cancer Risk

MONDAY, Dec. 4, 2017 (HealthDay News) -- Oral microbiome composition is associated with the risk of esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC), according to a study published online Dec. 1 in Cancer Research.

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Differences in Cancer Survival by Type of Insurance

FRIDAY, Dec. 1, 2017 (HealthDay News) -- From 1997 to 2014, improvements in cancer survival were mainly limited to patients with private or Medicare insurance, according to a study published online Nov. 30 in JAMA Oncology.

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>40% of Cancers, Cancer Deaths Due to Modifiable Risk Factors

FRIDAY, Dec. 1, 2017 (HealthDay News) -- An estimated 42.0 percent of all incident cancers and 45.1 percent of cancer deaths in the United States are attributed to potentially modifiable risk factors, according to a study published online Nov. 21 in CA: A Cancer Journal for Clinicians.

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Lower Microbial Diversity in the Gut in Anorexia Nervosa

FRIDAY, Dec. 1, 2017 (HealthDay News) -- Females with anorexia nervosa (AN) have lower gut microbial diversity, according to a study published online Nov. 13 in the International Journal of Eating Disorders.

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