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Home  >  Conferences  >  EMBL Course: Circulating Tumour DNA in Clinical Applications

EMBL Course: Circulating Tumour DNA in Clinical Applications

Mar 09 - 12, 2020   |   Heidelberg, Baden-Wurttemberg  Germany
Specialties : Genetics   |   Pathology   |   Oncology
Conference Brochure

EMBL Course: Circulating Tumour DNA in Clinical Applications is organized by European Molecular Biology Laboratory (EMBL) and will be held from Mar 09 - 12, 2020 at EMBL Advanced Training Centre, Heidelberg, Baden-Wurttemberg, Germany.

The course is aimed at scientists, clinical scientists, molecular pathologists and industry researchers who would like to learn about possible applications and want to gain hands-on experience in the field of liquid biopsy from sample acquisition, target enrichment, analysis and interpretation.

Course Overview:
Minimally invasive liquid biopsies have recently emerged as novel diagnostic methods which hold the promise to monitor disease progression, detect minimal residual disease, therapy resistance and potentially even early cancer detection. Participants will gain hands-on experience in the detection of cell free tumor DNA (cfDNA) using a next generation sequencing (NGS) approach that covers all four mutation classes in a single assay. Critical aspects on recent developments to increase analytical sensitivity and mitigate sequencing errors (computational error correction) will be discussed as well as annotation, interpretation, and clinical reporting of liquid biopsy tests. Lectures will cover the evaluation of ctDNA as biomarkers, clinical applications, emerging analytes for liquid biopsy and important challenges.

• Possible use cases of nucleic acids in blood and plasma in clinical settings
• Strategies for the construction of high quality NGS libraries from challenging cfDNA samples (sample and molecular barcoding, low input amounts, quality controls)
• In-solution hybridization based target enrichment of clinically relevant targets, covering all four mutation classes in a single assay (SNVs, fusions, indels, CNVs)
• Bioinformatics analysis including integrated digital error suppression (iDES), variant calling and reporting
• Annotation, interpretation of mutations and clinical reporting (therapy matching and optional clinical decision support)

Learning Outcomes:
• Understanding of potential applications for liquid biopsy in clinical care
• Challenges that must be overcome before liquid biopsies can be applied in precision medicine
• Overview of emerging liquid biopsy methods and markers
• Ability to handle cfDNA, generate NGS libraries, enrich targets of interest, annotate and interprate of variants and their frequences

Additional details will be posted as soon as information is available.

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Valentina Kovaleva
Valentina Kovaleva

Physiology and Biophysics

Carmen Rothmund
Carmen Rothmund

Molecular Biology

Irena Hudecova
Irena Hudecova

Molecular Biology

Leonie De Visser
Leonie De Visser


Registration Desk

Contact No. : +49 6221 378 8797
+49 6221 387-0
+39 06900 91402

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Venue Address

EMBL Advanced Training Centre
Meyerhofstraße 1
Heidelberg, Baden-Wurttemberg, Germany

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