Inflammasome Therapeutics Summit (ITS) 2019
Inflammasome Therapeutics Summit (ITS) is organized by Hanson Wade and will be held from Oct 29 - 31, 2019 at Revere Hotel Boston Common, Boston, Massachusetts, United States of America.
The potential to target the inflammasome as a therapeutic for many diseases is huge, with rapid advances and excitement in the field, now is the time combine forces and help accelerate development of truly curative inflammasome therapeutics.
The inaugural Inflammasome Therapeutics Summit (ITS) is industry's first dedicated discussion and networking forum focused on bringing together inflammasome thought-leaders to share the latest scientific progress and address the current challenges drug developers are facing. With the mission to bridge the gap between research and drug development and develop clinically effective candidates for inflammatory driven diseases.
Join 60 of your peers and be part of this unique opportunity to engage in cross-industry discussions and presentations from over 19 expert speakers on latest developments, sharing insights and science to elevate clinically effective inflammasome therapeutic pipelines.
Developed in combination with experts from Nodthera, Pfizer and IFM Therapeutics and other leading organisations, this industry focused forum allows you to determine which diseases the inflammasome is driving and therefore which have the most therapeutic potential commercially and clinically, review the basic biology and mechanisms of action and the use of biomarkers and endpoints for increased efficacy in clinical trials to name a few.
Leave ITS with a deeper understanding of the discovery, preclinical and clinical landscape of inflammasome therapeutics.
Tuesday October 29, 2019
Workshop A: 9:00 – 12:00
Delving Further into the Protein & Crystal Structures of Inflammasomes
Understanding the structure of key signaling molecules in the inflammasome pathway and understanding where the binding pockets are is key to advancing pre-clinical and clinical development of the inflammasome. Once the drug pockets are known, the location of where the drug can bind is known, hence, optimizing the drug. Exploring the protein structure of the inflammasome in its activated state is also key to getting a more efficacious drug.
This workshop will cover:
• Challenges of NLRP3 protein purification
• Cryo-EM data collection
• Data analysis and model building
• Challenges and considerations for NLRP3 drug discovery
Workshop B: 1:00 – 4:00
How do Inflammasome Inhibitors Work? Exploring the Mechanisms of Action of Inflammasome Formation & Inhibition
The inflammasome is a large protein complex that assembles and then activates cytokine signalling and cell death. Many compounds have been identified that can inhibit inflammasome signalling, however it is often not clear exactly how these compounds are working.
This workshop will cover the following questions:
• Are they binding to specific components of the inflammasome complex and preventing it from forming?
• Are they working upstream of the complex?
• Are they working indirectly through a different molecular target within the cell?
• What are the challenges and techniques involved in identifying the mechanism of action of inflammasome inhibitors?
This workshop aims to getting one step closer to answering these questions
Time: 09:00 to 17:00
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