Protein Homeostasis in Health and Disease is organized by Cold Spring Harbor Laboratory (CSH) and will be held during Apr 17 - 21, 2018 at Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America.
Proper expression, folding, transport, and clearance of proteins are critical for cell function and organismal health. Chaperones and enzymes that post-translationally assist newly synthesized proteins help ensure that they are correctly folded and functional, or are degraded. Translocation machineries, proteasomes, and autophagic activities are critical for subcellular localization and for degradation as necessary. Stress and aging challenge the robustness of these chaperone and clearance networks leading to protein mismanagement, overload, and cellular dysfunction. In humans, this is associated with the accumulation and aggregation of misfolded and aggregation-prone proteins, a feature of numerous neurodegenerative, metabolic, and oncogenic diseases.
Groundbreaking work - on molecular chaperones, the unfolded protein response, stress responses, and how these processes are implicated in disease - has first been presented at this meeting over the past three decades. This meeting provides an opportunity to showcase the latest research in this area and will feature two keynote talks by leading investigators who have contributed to the development of the field and who will put their current efforts in the context of past developments.
• Proteostasis at the ribosome and protein folding
• Chaperone mechanisms
• Novel mechanisms of quality control
• Degradation mechanisms
• Chaperone mechanisms II
• Aging and pathogenic aggregation
• Organellar proteostasis and spatial quality control
• Proteostasis failure and disease
• Panel Discussion - New Mechanisms for Disseminating Scientific Information
Additional details will be posted as soon as they are available.
|Contact No. :||(516) 367-8346|
February 02, 2018
|Registration Type||End Date||Price|
|Academic Package Fee||16 Apr,2018||USD 1485.00|
|Graduate/PhD Student Package Fee||16 Apr,2018||USD 1235.00|
|Corporate Package Fee||16 Apr,2018||USD 1905.00|
|Academic/Student No-Housing Package Fee||16 Apr,2018||USD 1005.00|
|Corporate No-Housing Package Fee||16 Apr,2018||USD 1280.00|