Chronic hepatitis C afflicts 170 million individuals worldwide and is a major cause of morbidity and mortality. We discuss the various modes of acquisition of hepatitis C. Although cirrhosis and its attendant complications including primary hepatocellular cardinoma are the major causes of morbidity and mortality, patients with chronic hepatitis C may also exhibit protean extrahepatic manifestations. On occasion, these dominate the clinical picture and account for serious morbidity and even mortality. Treatment options and definitions of types of responses are clearly delineated.
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